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Immune landscape and biomarkers for immuno-oncology in colorectal cancers

Bae JM, Yoo SY, Kim JH, Kang GH

Recent advances in immuno-oncology have increased understanding of the tumor immune microenvironment (TIME), and clinical trials for immune checkpoint inhibitor treatment have shown remission and/or durable response in certain proportions...
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The Relation of Autologous Serum Skin Test andAutologous Plasma Skin Test Result with VariousClinical and Laboratory Findings in Patients withChronic Spontaneous Urticaria

Park GH, Choi JH, Kim S, Bae Y

Background: Despite the autologous serum skin test (ASST)and autologous plasma skin test (APST) is widely used test accessingwhether a patient with chronic spontaneous urticaria(CSU) has autoreactivity or not, the clinician...
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Antioxidant and hepatoprotective effects of Korean ginseng extract GS-KG9 in a D-galactosamine-induced liver damage animal model

Jo YH, Lee H, Oh MH, Lee GH, Lee YJ, Lee JS, Kim MJ, Kim WY, Kim JS, Yoo DS, Cho SW, Cha SW, Pyo MK

BACKGROUND/OBJECTIVES: This study was designed to investigate the improvement effect of white ginseng extract (GS-KG9) on D-galactosamine (Ga1N)-induced oxidative stress and liver injury. SUBJECTS/METHODS: Sixty Sprague-Dawley rats were divided into 6...
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Evolving pathologic concepts of serrated lesions of the colorectum

Kim JH, Kang GH

Here, we provide an up-to-date review of the histopathology and molecular pathology of serrated colorectal lesions. First, we introduce the updated contents of the 2019 World Health Organization classification for...
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Subungual Ganglion Cyst Mimicking Glomus Tumor

Doh GH, Kim BS, Shin H, Ahn KC, Hong KY, Han YS, Eo S

Subungual masses accompanying nail deformity are of common occurrence and uniquely confirmed by histopathologic examination postoperatively. Although glomus tumor is most frequently diagnosed with its specific clinical triad, other rarer...
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Successful Treatment of a Korean Infant with Giant Cell Hepatitis with Autoimmune Hemolytic Anemia Using Rituximab

Kim YH, Kim JW, Lee EJ, Kang GH, Kang HJ, Moon JS, Ko JS

Giant cell hepatitis with autoimmune hemolytic anemia (AHA) is a rare disease of infancy characterized by the presence of both Coombs-positive hemolytic anemia and progressive liver disease with giant cell...
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Correlation between Accelerometer and Questionnaire-Based Assessment of Physical Activity in Patients with Cerebral Palsy

Kwon KB, Choi Y, Sung KH, Chung CY, Lee KM, Kwon SS, Cho GH, Park MS

BACKGROUND: Precise measuring and monitoring of physical activity (PA) in patients with cerebral palsy (CP) are critical for assessing their PA participation and its potential health benefits. Accelerometer-based assessment of...
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Standardized Pathology Report for Colorectal Cancer, 2nd Edition

Kim Bh, Kim JM, Kang GH, Chang HJ, Kang DW, Kim JH, Bae JM, Seo AN, Park HS, Kang YK, Lee KH, Cho MY, Do IG, Lee HS, Chang HK, Park DY, Kang HJ, Sohn JH, Chang MS, Jung ES, Jin SY, Yu E, Han HS, Kim YW, The Gastrointestinal Pathology Study Group of the Korean Society of Pathologists

The first edition of the ‘Standardized Pathology Report for Colorectal Cancer,’ which was developed by the Gastrointestinal Pathology Study Group (GIP) of the Korean Society of Pathologists, was published 13...
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Fibroblast Growth Factor Receptor 1 (FGFR1) Amplification Detected by Droplet Digital Polymerase Chain Reaction (ddPCR) Is a Prognostic Factor in Colorectal Cancers

Bae JM, Wen X, Kim TS, Kwak Y, Cho NY, Lee HS, Kang GH

Purpose The purpose of this study was to reveal the clinicopathological characteristics and prognostic implications associated with fibroblast growth factor receptor 1 (FGFR1) amplification in colorectal cancers (CRCs). Materials and Methods We measured...
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Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma

Yoo SY, Lee JA, Shin Y, Cho NY, Bae JM, Kang GH

BACKGROUND: SMAD family member 4 (SMAD4) has gained attention as a promising prognostic factor of colorectal cancer (CRC) as well as a key molecule to understand the tumorigenesis and progression...
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Soft tissue reconstruction in wide Tessier number 3 cleft using the straight-line advanced release technique

Kim GH, Baek RM, Kim BK

Craniofacial cleft is a rare disease, and has multiple variations with a wide spectrum of severity. Among several classification systems of craniofacial clefts, the Tessier classification is the most widely...
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Study of the Residential Environment and Accessibility of Rehabilitation for Patients with Cerebral Palsy

Cho GH, Chung CY, Lee KM, Sung KH, Cho BC, Park MS

PURPOSE: This study examined the residential environment and accessibility of rehabilitation for cerebral palsy (CP) to identify the problems with residential laws pertaining to the disabled and provide basic data...
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Comparison of Psychological Characteristics of Lesch Types 2 (Anxiety Model) and 3 (Depressive Model) Alcoholism

Jang SH, Chang MH, Jae YM, Choi JH, Lee GH

BACKGROUND: Lesch types 2 (L2, anxiety model) and 3 (L3, depressive model) of alcoholism exhibit different responses to anti-craving agents, and most treatment guidelines provide differential treatment strategies for bipolar...
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CpG Island Methylation in Sessile Serrated Adenoma/Polyp of the Colorectum: Implications for Differential Diagnosis of Molecularly High-Risk Lesions among Non-dysplastic Sessile Serrated Adenomas/Polyps

Lee JA, Park HE, Yoo SY, Jeong S, Cho NY, Kang GH, Kim JH

BACKGROUND: Although colorectal sessile serrated adenomas/polyps (SSA/Ps) with morphologic dysplasia are regarded as definite high-risk premalignant lesions, no reliable grading or risk-stratifying system exists for non-dysplastic SSA/Ps. The accumulation of...
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Impact of Mucin Proportion in the Pretreatment MRI on the Outcomes of Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiotherapy

Kim E, Kim K, Kim SH, Han SW, Kim TY, Jeong SY, Park KJ, Koh J, Kang GH, Chie EK

PURPOSE: The purpose of this study was to evaluate treatment response to neoadjuvant chemoradiotherapy (CRT) with regard to mucin status in pathology and pretreatment magnetic resonance imaging (MRI) in locally...
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The Relationship between Epidemiologic Factors and Usage Pattern of Hair Care Products in Korea

Park KD, Park BC, Sung KH, Lee E, Lee T, Yoon D, Kim KB, Park GH, Park IY, Kim MH

BACKGROUND: For hair care products that are used almost everyday, it is important to estimate the cumulative dosage of long-term exposure and to assess the effects on the human body....
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Metformin, an Activator of AMPK, Promotes the Growth of Hair Follicles via the AMPK/β-catenin Signaling Pathway

Moon HR, Park KY, Kang HJ, Lee WJ, Won CH, Chang SE, Lee MW, Choi JH, Park GH

  • KMID: 2449198
  • Korean J Dermatol.
  • 2019 May;57(4):175-181.
BACKGROUND: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a pivotal role in the balance of cellular energy metabolism. Recent studies have reported that AMPK has numerous...
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Sternal Tuberculosis: A Case Report

Kim GH, Kim SW

The sternum is a very rarely involved site in extrapulmonary tuberculosis. Here, we present a case of sternal tuberculosis, and review the literature. An 84-year-old female patient visited Seoul National...
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Solitary intraventricular hemorrhage without subarachnoid hemorrhage due to aneurysmal rupture: a case report

Kim SS, Go KO, Park H, Lee K, Ryu GH, Baek HJ, Jung S, Yoon CH, Park YS, Hwang SH

The presence of primary intraventricular hemorrhage (IVH) without vascular lesion is very rare. We experienced solitary IVH without subarachnoid hemorrhage due to aneurysmal rupture in a 58-year-old man treated with...
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Benign Recurrent Intrahepatic Cholestasis Type 2 in Siblings with Novel ABCB11 Mutations

Sohn MJ, Woo MH, Seong MW, Park SS, Kang GH, Moon JS, Ko JS

Benign recurrent intrahepatic cholestasis (BRIC), a rare cause of cholestasis, is characterized by recurrent episodes of cholestasis without permanent liver damage. BRIC type 2 (BRIC2) is an autosomal recessive disorder...
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