- Comparison of Macrophage Activation and Tumor - cytotoxicity in Mouse and hamster Peritoneal Macrophages by Cold Stress
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Jung NP, Choi IH, Oh YK, Shin HC, Jeon HK, Gwag BJ
- KMID: 1548375
- Korean J Immunol.
- 1997 Dec;19(4):505-512.
No abstract available. -
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- Iron mediates endothelial cell damage and blood-brain barrier opening in the hippocampus after transient forebrain ischemia in rats
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Won SM, Lee JH, Park UJ, Gwag J, Gwag BJ, Lee YB
- KMID: 1097269
- Exp Mol Med.
- 2011 Feb;43(2):121-128.
- doi: 10.3858/emm.2011.43.2.020
Blood cells are transported into the brain and are thought to participate in neurodegenerative processes following hypoxic ischemic injury. We examined the possibility that transient forebrain ischemia (TFI) causes the... -
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- Effect of MK801 and CNQX on Retinal Injury Induced by Ischemia, NMDA, or Kainate
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Choi JS, Gwag BJ, Yoon SK, Joo CK
- KMID: 2108525
- J Korean Ophthalmol Soc.
- 1998 Aug;39(8):1794-1800.
To examine the protection of retinal cell death by glutamate antagonists in vivo, this study was carried out in pressure-induced ischemia model. Firstly, we observed that ischemia resulted in the... -
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- Lithium Potentiates the FeCl2 Induced Free Radical Injury in Primary Mouse Cortical Cell Culture
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Lee SH, Lee YA, Byun HY, Gwag BJ, Chung YK, Noh JS
- KMID: 2287143
- Korean J Psychopharmacol.
- 2006 Sep;17(5):468-474.
OBJECTIVES: For the past half century, lithium has been used for the acute and prophylactic treatment of bipolar disorder and recurrent depression. Recently, new pharmacological effects of Li+ have appeared,... -
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- Expression of p53 in Retina Neuronal Cell Death Induced by Ischemia and Reperfusion
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Choi JS, Gwag BJ, Kim SJ, Chun MH, Joo CK
- KMID: 2205401
- J Korean Ophthalmol Soc.
- 1998 Nov;39(11):2679-2686.
In order to elucidate the mechanism of neuronal cell death induced by retina ischemia and reperfusion, we investigated expression of p53, Bcl-2, and ICE(interleukin converting enzyme) in retinal neuronal cell... -
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- Neuronal Cell Death in Reina Ischemia Induced by Elevation of Intraocular Pressure
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Choi JS, Gwag BJ, Kim SJ, Chun MH, Joo CK
- KMID: 2205403
- J Korean Ophthalmol Soc.
- 1998 Nov;39(11):2701-2708.
This study was conducted to compare degeneration of retinal neurons in retina ischemia induced by sudden elevation of intraocular pressure(IOP)(Group A) with that by steady elevation of IOP(Group B). Adult... -
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- Neurotrophins and IGFs Attenuated Haloperidol-Induced Neuronal Apoptosis in Mouse Cortical Cell Cultures
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Kang HJ, Yoon KJ, Gwag BJ, Chung YK, Noh JS
- KMID: 2340491
- J Korean Neuropsychiatr Assoc.
- 2000 Sep;39(5):920-927.
OBJECTIVES: We examined the effects of neurotrophins and insulin-like growth factors on cell death induced by haloperidol, a typical anti-psychotic agent. METHOD: Neocortices from 14- or 15-daysold fetal mice for neuron-glia... -
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- Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice
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Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ
- KMID: 946638
- Exp Mol Med.
- 2010 May;42(5):386-394.
- doi: 10.3858/emm.2010.42.5.040
The endoplasmic reticulum (ER) stress results from disrupted protein folding triggered by protein mutation or oxidation, reduced proteasome activity, and altered Ca2+ homeostasis. ER stress is accompanied by activation of... -
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- AAD-2004 Attenuates Progressive Neuronal Loss in the Brain of Tg-betaCTF99/B6 Mouse Model of Alzheimer Disease
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Baek IS, Kim TK, Seo JS, Lee KW, Lee YA, Cho J, Gwag BJ, Han PL
- KMID: 2165439
- Exp Neurobiol.
- 2013 Mar;22(1):31-37.
- doi: 10.5607/en.2013.22.1.31
Alzheimer's disease (AD) is a neurodegenerative disease that proceeds with the age-dependent neuronal loss, an irreversible event which causes severe cognitive and psychiatric devastations. In the present study, we investigated... -
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- Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
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Lee HG, Won SM, Gwag BJ, Lee YB
- KMID: 991618
- Exp Mol Med.
- 2011 Jan;43(1):7-14.
- doi: 10.3858/emm.2011.43.1.001
The possibility that P2X7 receptor (P2X7R) expression in microglia would mediate neuronal damage via reactive oxygen species (ROS) production was examined in the APPswe/PS1dE9 mouse model of Alzheimer's disease (AD).... -
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- 6-hydroxydopamine Induces Neuronal Apoptosis in Mouse Cortical Cell Cultures
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Jung JH, Kang HJ, Sohn S, Chung YK, Gwag BJ, Noh JS
- KMID: 2340467
- J Korean Neuropsychiatr Assoc.
- 2000 May;39(3):656-665.
OBJECTIVES: We examined the patterns of cell death induced by the 6-hydroxydopamine, a selective dopaminergic toxin that used to produce Parkinson's disease model. METHOD: Neocortices from 14- or 15-day-old fetal mice... -
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- Early Administration of Nelonemdaz May Improve the Stroke Outcomes in Patients With Acute Stroke
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Lee JS, Lee JS, Ahn SH, Kang HG, Song TJ, Shin DI, Bae HJ, Kim CH, Heo SH, Cha JK, Lee YB, Kim EG, Park MS, Park HK, Kim J, Yu S, Mo H, Sohn SI, Kwon JH, Kim JG, Kim YS, Choi JC, Hwang YH, Jung KH, Kim SK, Seo WK, Seo JH, Yoo J, Chang JY, Park M, Yum KS, An CS, Gwag BJ, Choi DW, Hong JM, Kwon SU, the SONIC and RODIN Investigators
- KMID: 2568237
- J Stroke.
- 2025 May;27(2):279-283.
- doi: 10.5853/jos.2024.05113
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- The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz (RODIN) Trial: Protocol for a Double-Blinded Clinical Trial of Nelonemdaz in Patients with Hyperacute Ischemic Stroke and Endovascular Thrombectomy
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Lee JS, Lee JS, Gwag BJ, Choi DW, An CS, Kang HG, Song TJ, Ahn SH, Kim CH, Shin DI, Kwon SU
- KMID: 2539069
- J Stroke.
- 2023 Jan;25(1):160-168.
- doi: 10.5853/jos.2022.02453
Background and Purpose Nelonemdaz (Neu2000) has both selective antagonism against 2B subunit of N-methyl-D-aspartate receptor and antioxidant activity. This drug provides sufficient evidence of neuroprotection in acute cerebral ischemia/reperfusion models.... -
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