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Effectiveness of three different luteinizing hormone-releasing hormone agonists in the chemical castration of patients with prostate cancer: Goserelin versus triptorelin versus leuprolide

Shim M, Bang WJ, Oh CY, Lee YS, Cho JS

PURPOSE: To investigate the changes in testosterone levels and rates of chemical castration following androgen-deprivation therapy (ADT) with goserelin, triptorelin, and leuprolide. MATERIALS AND METHODS: We retrospectively reviewed the medical records...
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Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus

Shin MS, Kim TW, Park SS, Ko IG, Kim CJ, Kim M, Roh SY, Kim KT, Kim KH

PURPOSE: Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine...
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Durable Response of Androgen Receptor-Positive Male Breast Cancer to Goserelin

Abdel Azim H, Kassem L, Shohdy KS, Eshaak B, Anis SE, Kamal NS

The luteinizing hormone-releasing hormone/androgen receptor (LHRH/AR) pathway is a promising treatment target in a subgroup of female patients with triple-negative breast cancer (TNBC). However, very little is known about the...
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Efficacy of Combined Aromatase Inhibitor and Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Metastatic Breast Cancer

Kim SH, Choi J, Park CS, Kim HA, Noh WC, Seong MK

PURPOSE: Endocrine therapy is the preferred treatment for hormone receptor (HR)-positive metastatic breast cancer (MBC). We investigated the efficacy of combined aromatase inhibitor (AI) and luteinizing hormone-releasing hormone (LHRH) agonist...
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Agoraphobia and Follicle-Stimulating Hormone Levels between Tamoxifen and Goserelin versus Tamoxifen Alone in Premenopausal Hormone Receptor-Positive Breast Cancer: A 12-Month Prospective Randomized Study

Heo JY, Yi H, Fava M, Mischoulon D, Kim K, Yoon S, Jeon HJ, Lee JE

OBJECTIVE: Tamoxifen is an estrogen receptor antagonist used to prevent recurrence of breast cancer, which may provoke depression and anxiety and increase follicle-stimulating hormone (FSH) to patients. We compared anxiety...
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Ovarian Ablation Using Goserelin Improves Survival of Premenopausal Patients with Stage II/III Hormone Receptor-Positive Breast Cancer without Chemotherapy-Induced Amenorrhea

Zhou J, Wu SG, Wang JJ, Sun JY, Li FY, Lin Q, Lin HX, He ZY

PURPOSE: The purpose of this study was to assess the value of ovarian ablation using goserelin in premenopausal patients with stage II/III hormone receptor-positive breast cancer without chemotherapy-induced amenorrhea (CIA). MATERIALS...
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A Case of an Adolescent with Paraphilia with Depot GnRH Analogue (Goserelin)

Kim HS, Park WS, Lee JW, Lim MH

  • KMID: 2287487
  • Korean J Psychopharmacol.
  • 2011 Oct;22(4):230-236.
Paraphilia was a very treatment resistant psychiatric disorder. But new treatment strategies to paraphilia have been introduced recently. We report and review the effect of depot analogue (goserelin) administration in...
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A Case of Cyclic Vomiting Syndrome Responding to Gonadotropin-Releasing Hormone Analogue

Shin YK, Kwon JG, Kim KY, Park JB, Han SJ, Cheon JW, Kim EY, Kim HG, Lee TS, Park KS, Won KS

  • KMID: 2326121
  • J Neurogastroenterol Motil.
  • 2010 Jan;16(1):77-82.
Cyclic vomiting syndrome (CVS) is a disorder characterized by recurrent episodes of incapacitating nausea and vomiting interspersed with symptom free periods. Common triggers of cyclic vomiting include noxious stress, excitement,...
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Comparison of Clinical Efficacy between a Single Administration of Long-Acting Gonadotrophin-Releasing Hormone Agonist (GnRHa) and Daily Administrations of Short-Acting GnRHa in In Vitro Fertilization-Embryo Transfer Cycles

Cheon KW, Song SJ, Choi BC, Lee SC, Lee HB, Yu SY, Yoo KJ

This study was aimed to evaluate the efficacy of a single administration of long-acting gonadotrophin-releasing hormone agonist (GnRHa) as compared with daily administrations of short-acting GnRHa in controlled ovarian hyperstimulation...
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Incidence Rate of Injection-Site Granulomas Resulting from the Administration of Luteinizing Hormone-Releasing Hormone Analogues for the Treatment of Prostatic Cancer

Shiota M, Tokuda N, Kanou T, Yamasaki H

PURPOSE: Granulomas resulting from the administration of luteinizing hormone-releasing hormone analogues (LH-RH analogues) are thought to be very rare. We report on our clinical experience with injection-site granulomas that result...
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Effects of Intermittent Androgen Suppression in the Treatment of Prostate Cancer: Cycling Changes and Characteristics

Kim JH, Park CH, Kim CI

  • KMID: 2292619
  • Korean J Urol.
  • 2002 May;43(5):386-390.
PURPOSE: The purpose of this study was to evaluate cycling change and characteristics of treatment in patients receiving intermittent androgen suppression (IAS). MATERIALS AND METHODS: From May 1995 to April 2001,...
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Therapeutic Effect of Maximal Androgen Blockade in Metastatic Prostate Cancer

Jeong SJ, Kwak C, Lee SE

  • KMID: 2292320
  • Korean J Urol.
  • 2001 Jun;42(6):642-649.
PURPOSE: We aimed to evaluate the therapeutic effect of maximal androgen blockade (MAB) compared with that of medical or surgical castration alone in the treatment of the metastatic prostate cancer. MATERIALS...
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Pathologic Changes in Uterine Leiomyomas Treated by GnRH Agonist Goserelin

Ju ES, Kim IG, Oh YE, Cho YL

  • KMID: 2270061
  • Korean J Obstet Gynecol.
  • 2001 Feb;44(2):263-267.
OBJECTIVE: To define the pathologic changes underlying the mechanism of shrinkage of uterine leimyoma in patients treated with goserelin. METHODS: Retrospective evaluation of pathologic changes seen in leiomyoma removed by hysterectomy...
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The changes of bone mineral density and biochemical bone markers after GnRH agonist treatment in patients with endometriosis

Park HM, Hur M, Kim YS

  • KMID: 2261790
  • Korean J Obstet Gynecol.
  • 2000 Jan;43(1):87-94.
OBJECTIVE: To investigate the basal bone mineral density(BMD)s of the lumbar spine and femur of patients with endometriosis, and the changes of BMDs and biochemical bone markers after 6 months...
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Role of Color Doppler US in the Evaluation of Uterine Leiomyoma Treated with Gonadotrophin-Releasing Hormone (GnRH) Agonist (Zoladex)

Kim JS, Sohn CH, Lee TS

  • KMID: 1838420
  • J Korean Soc Med Ultrasound.
  • 1999 Mar;18(1):47-51.
PURPOSE: To access the role of color Doppler US in the evaluation of uterine leiomyoma treated with GnRH agonist (Zoladex). MATERIALS AND METHODS: Out of 25 patients with uterine leiomyoma...
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Intermittent Androgen Deprivation with Goserelin and Flutamide for Prostate Cancer: a Pilot Study

Jeon SS, Choi HY

  • KMID: 2290125
  • Korean J Urol.
  • 1999 Oct;40(10):1295-1300.
PURPOSE: The purpose of this study was to evaluate the feasibility of using intermittent androgen deprivation(IAD) in patients with prostate cancer. MATERIALS AND METHODS: We reviewed the medical records of 29...
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A Combined Treatment of Tamoxifen, Goserelin, and Sulindac in 2 Cases of Recurrent Desmoid Tumor in the Abdomen

Kim HC, Suh BS, Lee DH, Ahn BY, Chung CS, Kang GH, Ha HK, Kim JC

  • KMID: 2142366
  • J Korean Soc Coloproctol.
  • 1999 Oct;15(4):339-343.
Desmoid tumor is a subtype of fibromatosis arising from deep fascial or soft tissue structure. It is characterized by locally aggressive behavior with a tendency to local recurrence, but is...
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A Study of Secondlook Laparoscopic Findings After 6 Months GnRH Agonist Therapy in Endometriosis

Chi JS, Suh YS, Seo JH, Park HM, Hur M

  • KMID: 2261057
  • Korean J Obstet Gynecol.
  • 1998 Jul;41(7):1844-1849.
Endometriosis is a disease defined as the presence of endometrial tissue outside the uterus. The goal of treatment is to eliminate the endometriotic lesion and to treat sequellae. But no...
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Ketoconazole with Prednisolone for the Treatment of Hormone Refractory Prostate Cancer

Lee BT, Kim CI

  • KMID: 2290066
  • Korean J Urol.
  • 1998 Oct;39(10):1001-1005.
PURPOSE: Corticosteroids suppress the pituitary production of adrenocorticotropic hormone resulting in decreased adrenal steroid production, including adrenal androgens. Ketoconazole is an imidazole fungal agent that inhibit both testicular and adrenal...
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