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Ameliorating Effects of Sulfonylurea Drugs on Insulin Resistance in Otsuka Long-Evans Tokushima Fatty Rats

Park JK, Kim SP, Song DK

OLETF (Otsuka Long-Evans Tokushima Fatty) rats are characterized by obesity-related insulin resistance, which is a phenotype of type 2 diabetes. Sulfonylurea drugs or benzoic acid derivatives as inhibitors of the...
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DEND Syndrome with Heterozygous KCNJ11 Mutation Successfully Treated with Sulfonylurea

Cho JH, Kang E, Lee BH, Kim GH, Choi JH, Yoo HW

Permanent neonatal diabetes mellitus (PNDM) is caused by mutations in the ATP-sensitive potassium channel (K(ATP) channel) subunits. Developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome is the most severe form...
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The Inhibitory Effect of the Second Generation Sulfonylurea Drugs on Cytochrome P450-catalyzed Reaction by Human Liver Microsomes

Choi JY, Kim SY, Kim KA, Park JY

  • KMID: 2199993
  • J Korean Soc Endocrinol.
  • 2002 Aug;17(4):544-553.
BACKGROUND: Sulfonylurea drugs have been used for many decades as one of the main families of drugs for the treatment of type 2 diabetes mellitus. Even though there are many...
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Efficacy and Safety of Glimepiride: A Novel Sulfonylurea Drug compared with Gliclazide in the Treatment of Type 2 Diabetes Mellitus: an Open , Randomized Comparative Multi - Center Clinical Study

Hong SK, Lee KU, Oh YS, Son HY, Kim KW, Lee HC, Kim KR, Choi DS, Park IB, Kim YS, Lee KW, Lee HK, Shin SH

  • KMID: 2177982
  • J Korean Diabetes Assoc.
  • 1999 Feb;23(1):87-97.
BACKGROUND: Glimepiride (HOE490, Amaryl (R)) is a new, third generation sulfonylurea, which binds to a different protein of the sulfonylurea receptor than other sulfonylureas. Although there have been many studies...
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Effects of Pioglitazone on Cerebral Hemodynamics in Patients of Type 2 Diabetes

Park JS, Lee YJ, Kim CS, Kim HJ, Park J, Ahn CW, Lee KY, Kim HJ, Won YJ, Ha HJ, Kwak HS, Cha BS, Lim SK, Kim KR, Lee HC

BACKGROUND: Atherosclerosis is one of the major causes of morbidity and mortality in patients with type 2 diabetes and pioglitazone has been reported to have antiatherogenic effect. The aim of...
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Concurrent Use of Sulfonylureas and Antimicrobials of the Elderly in Korea: A Potential Risk of Hypoglycemia

Lee S, Ock M, Kim H

BACKGROUND: Previous studies have noted that the simultaneous use of sulfonylureas and antimicrobials, which is common, could increase the risk of hypoglycemia. In particular, an age of 65 years or...
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Increasing Trend in the Number of Severe Hypoglycemia Patients in Korea

Kim JT, Oh TJ, Lee YA, Bae JH, Kim HJ, Jung HS, Cho YM, Park KS, Lim S, Jang HC, Lee HK

BACKGROUND: To investigate whether the number of subjects with severe hypoglycemia who are brought to a hospital emergency department is increasing and to identify whether there have been changes in...
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Factors Associated with Compliance Using Diamicron in Patients with Type 2 Diabetes

Lee JA, Park KM, Sunwoo S, Yang YJ, Seo YS, Song SW, Kim BS, Kim YS

  • KMID: 2247107
  • Korean J Health Promot.
  • 2012 Jun;12(2):75-82.
BACKGROUND: Diabetes mellitus (DM) is one of the most important chronic diseases in public health, thus optimal management of this condition is crucial. For this purpose, oral hypoglycemic agents (OHA)...
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Regulation of Glucose Control in People with Type 2 Diabetes: A Review and Consensus

Woo JT, Park KS, Byun DW, Ko KS, Chung YS, Kim DM, Park TS, Cha BS, Lee IK, Park JY, Son HS, Lee MK, Kim KW, Son HY

A conference was convened by the Korean Diabetes Association and the Korean Endocrine Society on September 7, 2009 to discuss and organize the results of research on intensive glucose control...
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