- D60-sensitive tyrosine phosphorylation is involved in Fas-mediated phospholipase D activation
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Kim JG, Shin IC, Lee KS, Han JS
- KMID: 1457546
- Exp Mol Med.
- 2001 Dec;33(4):303-309.
Both Fas and PMA can activate phospholipase D via activation of protein kinase Cbeta in A20 cells. Phospholipase D activity was increased 4 fold in the presence of Fas and... -
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- Antiproliferation and Redifferentiation in Thyroid Cancer Cell Lines by Polyphenol Phytochemicals
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Kang HJ, Youn YK, Hong MK, Kim LS
- KMID: 1094260
- J Korean Med Sci.
- 2011 Jul;26(7):893-899.
- doi: 10.3346/jkms.2011.26.7.893
Thyroid carcinogenesis is accompanied by loss of thyroid-specific functions and refractory to radioiodine and thyroid stimulating hormone (TSH) suppression therapy. Redifferentiating agents have been shown to inhibit tumor growth and... -
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- Stimulation of macrophage function by S-antigen: production of nitric oxide
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Bae SR
- KMID: 754267
- Korean J Ophthalmol.
- 2000 Jun;14(1):12-19.
- doi: 10.3341/kjo.2000.14.1.12
In this study, we investigated whether retinal soluble proteins, such as S-antigen, play a role in the induction of nitric oxide by macrophages in vitro. Cells from the murine macrophage... -
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- Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1
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Seo YJ, Kim BS, Chun SY, Park YK, Kang KS, Kwon TG
- KMID: 1123450
- J Korean Med Sci.
- 2011 Nov;26(11):1489-1494.
- doi: 10.3346/jkms.2011.26.11.1489
Natural isoflavones and flavones are important dietary factors for prostate cancer prevention. We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and... -
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- zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells
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Yee SB, Baek SJ, Park HT, Jeong SH, Jeong JH, Kim TH, Kim JM, Jeong BK, Park BS, Kwon TK, Yoon I, Yoo YH
- KMID: 1115941
- Exp Mol Med.
- 2006 Dec;38(6):634-642.
In a preliminary study, we found that benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD- fmk), unlike Boc-aspartyl(OMe)-fluoromethylketone (BocD-fmk), at usual dosage could not prevent genistein-induced apoptosis of p815 mastocytoma cells. This study was undertaken to... -
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- Corn silk induces nitric oxide synthase in murine macrophages
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Kim KA, Choi SK, Choi HS
- KMID: 1103321
- Exp Mol Med.
- 2004 Dec;36(6):545-550.
Corn silk has been purified as an anticoagulant previously and the active component is a polysaccharide with a molecular mass of 135 kDa. It activates murine macrophages to induce nitric... -
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- Cross-linking of CD4 induces cytoskeletal association of CD4 and p56lck
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Ha-Lee YM, Lee YS, Kim YK, Sohn JW
- KMID: 927129
- Exp Mol Med.
- 2000 Mar;32(1):18-22.
A membrane glycoprotein CD4 functions as a co-receptor of a T lymphocyte. The co-receptor function has been attributed to a protein tyrosine kinase, p56lck, which is activated upon CD4 binding... -
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- The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells
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Kim YD, Bae YS, Park JC, Suh PG, Ryu SH
- KMID: 1457539
- Exp Mol Med.
- 2001 Dec;33(4):257-262.
His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that stimulates Jurkat T cells resulting in intracellular calcium ([Ca2+]i) increase in a pertussis toxin (PTX)-sensitive manner. We have examined the physiological role of... -
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- Impact of Lysophosphatidylcholine on the Plasminogen Activator System in Cultured Vascular Smooth Muscle Cells
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Yoon BK, Kang YH, Oh WJ, Park K, Lee DY, Choi D, Kim DK, Lee Y, Rhyu MR
- KMID: 2157928
- J Korean Med Sci.
- 2012 Jul;27(7):803-810.
- doi: 10.3346/jkms.2012.27.7.803
The balance between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis. PAI-1 expression increases in atherosclerotic arteries and vascular smooth muscle cells (VSMCs) are one... -
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- Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C
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Kim J, Min G, Bae YS, Min DS
- KMID: 1380203
- Exp Mol Med.
- 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in... -
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- Interleukin-1beta promotes the expression of monocyte chemoattractant protein-1 in human aorta smooth muscle cells via multiple signaling pathways
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Lim JH, Um HJ, Park JW, Lee IK, Kwon TK
- KMID: 1009397
- Exp Mol Med.
- 2009 Oct;41(10):757-764.
- doi: 10.3858/emm.2009.41.10.082
Monocyte chemoattractant protein-1 (MCP1) plays a key role in monocyte/macrophage infiltration to the sub-endothelial space of the blood vessel wall, which is a critical initial step in atherosclerosis. In this... -
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- Signaling pathway for 2,3,7,8-tetrachlorodibenzo- p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages
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Cheon HJ, Woo YS, Lee JY, Kim HS, Kim HJ, Cho S, Won NH, Sohn J
- KMID: 756076
- Exp Mol Med.
- 2007 Aug;39(4):524-534.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototypic halogenated aromatic hydrocarbon (HAH), is known as one of the most potent toxicants. At least a part of its toxic effects appears to be derived from... -
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