- Loss of heterozygosity at the MCC and APC genetic loci in precancerous gastric lesion and gastric cancer
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Rhyu MG, Park WS, Jung YJ, Kim GR, Kim CS
- KMID: 1694260
- J Korean Cancer Assoc.
- 1992 Oct;24(5):695-701.
No abstract available. -
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- Study of the Allelic Frequency on Polymorphic Loci in the Short Arm of Chromosome 3 in Normal Koreans
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Son YJ, Kim IW, Yoon JH
- KMID: 1914084
- Korean J Urol.
- 1996 Oct;37(10):1087-1092.
The results of allelic frequency of polymorphic loci in the short arm of chromosome 3 in normal Koreans are shown using a polymerase chain reaction (PCR) based restriction fragment length... -
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- Genetics of Autism Spectrum Disorder: Current Status and Possible Clinical Applications
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Yoo H
- KMID: 2165563
- Exp Neurobiol.
- 2015 Dec;24(4):257-272.
- doi: 10.5607/en.2015.24.4.257
Autism spectrum disorder (ASD) is one of the most complex behavioral disorders with a strong genetic influence. The objectives of this article are to review the current status of genetic... -
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- A Follow-up Association Study of Genetic Variants for Bone Mineral Density in a Korean Population
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Ham S, Roh TY
- KMID: 2009098
- Genomics Inform.
- 2014 Sep;12(3):114-120.
- doi: 10.5808/GI.2014.12.3.114
Bone mineral density (BMD) is one of the quantitative traits that are genetically inherited and affected by various factors. Over the past years, genome-wide association studies (GWASs) have searched for... -
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- PCR-based Study on Loss of Heterozygosity at the Short Arm of Chromosome 3 in Renal Cell Carcinoma
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Yoon JH, Park YH, Kim IH
- KMID: 1991363
- Korean J Urol.
- 1996 Jul;37(7):730-738.
Loss of heterozygosity (LOH) at polymorphic loci on the short arm of chromosome 3 which has multiple recurrence genes was investigated in histopathologically proven 35 sporadic renal cell carcinoma (RCC)... -
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- Simultaneous Translocation of Both TCR Loci (14q11) with Rare Partner Loci (Xq22 and 12p13) in a Case of T-lymphoblastic Leukemia
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Kang DH, Kim SH, Jun JW, Lee YW, Shin HB, Ahn JY, Hong DS, Lee YK, Jeon BR
- KMID: 1381689
- Ann Lab Med.
- 2012 May;32(3):220-224.
- doi: 10.3343/alm.2012.32.3.220
The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve T-cell receptor (TCR) loci and a variety of partner genes, including HOX11, HOX11L2, MYC, and TAL1.... -
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- Sulwon Lecture 2009: The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus
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Park KS
- KMID: 2281487
- Diabetes Metab J.
- 2011 Feb;35(1):12-22.
- doi: 10.4093/dmj.2011.35.1.12
Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach,... -
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- Genetic Polymorphism Predisposing to Differentiated Thyroid Cancer: A Review of Major Findings of the Genome-Wide Association Studies
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Saenko VA, Rogounovitch TI
- KMID: 2420483
- Endocrinol Metab.
- 2018 Jun;33(2):164-174.
- doi: 10.3803/EnM.2018.33.2.164
Thyroid cancer has one of the highest hereditary component among human malignancies as seen in medical epidemiology investigations, suggesting the potential meaningfulness of genetic studies. Here we review researches into... -
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- Genetic Studies of Psychiatric Disorders: The Basic Concepts and Methods of Quantitative Genetics
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Joo EJ, Kim YS
- KMID: 2340432
- J Korean Neuropsychiatr Assoc.
- 2000 Mar;39(2):257-272.
Quantitative medical genetics including genetic epidemiological studies, linkage studies, and association studies are the basis for molecular genetic studies to find the susceptible genes or responsible mutations for psychiatric disorders.... -
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- KARE Genomewide Association Study of Blood Pressure Using Imputed SNPs
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Hong KW, Lim JE, Kim YJ, Cho NH, Shin C, Oh B
- KMID: 2284663
- Genomics Inform.
- 2010 Sep;8(3):103-107.
The imputation of untyped SNPs enables researchers to validate association findings across SNP arrays and also enables them to test a large number of SNPs to reveal the fine structure... -
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- Pathogenic Mechanism of Alzheimer's Disease
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Han SH
- KMID: 2053696
- Hanyang Med Rev.
- 2006 Feb;26(1):4-13.
Alzheimer's disease (AD) is regarded as a prototype of the neurodegenerative disorder characterized by progressive memory impairment and multiple cognitive deficits in mid- to late- life. Its pathological hallmarks consist... -
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- Epigenetic Alterations in Inflammatory Bowel Disease and Cancer
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Yi JM, Kim TO
- KMID: 2284877
- Intest Res.
- 2015 Apr;13(2):112-121.
- doi: 10.5217/ir.2015.13.2.112
Overwhelming evidences supports the idea that inflammatory bowel disease (IBD) is caused by a complex interplay between genetic alterations of multiple genes and an aberrant interaction with environmental factors. There... -
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- Recent progress in genetic and epigenetic research on type 2 diabetes
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Kwak SH, Park KS
- KMID: 2361507
- Exp Mol Med.
- 2016 Mar;48(3):e220.
- doi: 10.1038/emm.2016.7
Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong genetic predisposition. During the past decade, progress in genetic association studies has enabled the identification of... -
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- Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
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Lee HI, Kim JJ, Park T, Kim K, Lee JE, Cho YS, Lee JY, Han BG, Lee JK
- KMID: 2053263
- Genomics Inform.
- 2011 Jun;9(2):59-63.
Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify... -
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- Genetics of Cerebral Small Vessel Disease
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Choi JC
- KMID: 2223682
- J Stroke.
- 2015 Jan;17(1):7-16.
- doi: 10.5853/jos.2015.17.1.7
Cerebral small vessel disease (SVD) is an important cause of stroke and cognitive impairment among the elderly and is a more frequent cause of stroke in Asia than in the... -
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- Genome-Wide Association Study of Liver Enzymes in Korean Children
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Park TJ, Hwang JY, Go MJ, Lee HJ, Jang HB, Choi Y, Kang JH, Park KH, Choi MG, Song J, Kim BJ, Lee JY
- KMID: 2009108
- Genomics Inform.
- 2013 Sep;11(3):149-154.
- doi: 10.5808/GI.2013.11.3.149
Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their... -
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- A Case of Juvenile Onset Spinocerebellar Ataxia Type 3
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Kim JS, Kim YI, Lee KS, Jin DK
- KMID: 2329239
- J Korean Child Neurol Soc.
- 2000 Dec;8(2):329-332.
The genetic locus of spinocerebellar ataxia type 3 (SCA3) is linked to chromosome 14q 24.3-qter like Machado-Joseph disease (MJD). The number of CAG repeats on mutant chromosome correlates positively with severity of... -
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- The Genetic Basis of Panic Disorder
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Na HR, Kang EH, Lee JH, Yu BH
- KMID: 1785953
- J Korean Med Sci.
- 2011 Jun;26(6):701-710.
- doi: 10.3346/jkms.2011.26.6.701
Panic disorder is one of the chronic and disabling anxiety disorders. There has been evidence for either genetic heterogeneity or complex inheritance, with environmental factor interactions and multiple single genes,... -
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- Genome-wide Survey of Copy Number Variants Associated with Blood Pressure and Body Mass Index in a Korean Population
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Moon S, Kim YJ, Kim YK, Kim DJ, Lee JY, Go MJ, Shin YA, Hong CB, Kim BJ
- KMID: 2053271
- Genomics Inform.
- 2011 Dec;9(4):152-160.
Hypertension is the major factor of most death and high blood pressure (BP) can lead to stroke, myocardial infarction and cardiac failure. Moreover, hypertension is strongly correlated with body mass... -
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- Pathogenic Mechanisms and Causable Genes in Charcot-Marie-Tooth Disease
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Kim SB, Park KD, Choi BO
- KMID: 2053705
- Hanyang Med Rev.
- 2006 Feb;26(1):94-103.
Charcot-Marie-Tooth (CMT) disease is the most common form of inherited motor and sensory neuropathy. CMT is a genetically heterogeneous disorder of the peripheral nervous system; thus, many genes have been... -
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