- The Immunohistochemical Study of Oncogene and Tumor Suppressor Gene Proteins on Bone Tumor
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Kim MK, Yeom BW, Lee JH
- KMID: 2105099
- J Korean Orthop Assoc.
- 1997 Jun;32(3):623-631.
The discovery of oncogenes and tumor suppressor genes have made it possible to partly understand the mechanism of cancer development. It is generally accepted that the cancer development is caused... -
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- Expression of Extracellular Matrix, c-Ha-ras and c-myc genes in Cultured Pterygial Fibroblasts
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Kim KS, Kim SH, Suh SI, Suh MH
- KMID: 2022989
- J Korean Ophthalmol Soc.
- 1991 Nov;32(11):929-938.
Pterygium, a disease of unknown origin and pathogennesis, is a chronic condition characterized by the encroachment of triangular portion of the bulbar conjunctiva onto the cornea. We have studied the... -
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- Detection of N-myc Gene Amplification in Neuroblastoma Using the Semiquantitative Polymerase Chain Reaction
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Park DW, Lee CH, Yoon KJ, Kim HM, Yang WI
- KMID: 2225587
- Korean J Clin Pathol.
- 1997 Apr;17(2):351-359.
No abstract available. -
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- Cutaneous Angiosarcoma of the Foot Accompanied by Multiple Myeloma: The First Case Report
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Jo JW, Shin YB, Kwon CI, Kim CY
- KMID: 2457693
- Korean J Dermatol.
- 2019 Aug;57(7):399-402.
Although the exact etiology of cutaneous angiosarcoma remains unclear, MYC gene amplification has been recently discovered as a new pathogenesis. MYC is a proto-oncogene, and aberration of MYC signaling in... -
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- Expressions of c-fos and c-myc genes during 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB)-induced rat hepatocarcinoma
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Chai KJ, Kim JS, Lee HK
- KMID: 1120235
- Yonsei Med J.
- 1992 Sep;33(3):240-248.
- doi: 10.3349/ymj.1992.33.3.240
We investigated the expression of the growth-related nuclear proto-oncogenes, c-fos and c-myc, in early preneoplastic regions and tumor nodules of 3'-MeDAB induced rat hepatocarcinoma. To amplify the levels of these... -
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- Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma
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Choi SW, Lee TW, Yang SW, Hong WS, Kim CM, Lee JO
- KMID: 1421955
- J Korean Med Sci.
- 1993 Feb;8(1):73-77.
- doi: 10.3346/jkms.1993.8.1.73
We have analyzed paired samples of genomic DNA from peripheral leukocyte and primary tumor tissue from nine patients with retinoblastoma (RB) and from two RB cell lines, WERI-Rb-1 and Y79,... -
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- Expression of p53, p16, PTEN, and c-myc Gene with Cisplatin Treatment in Cisplatin Resistant Ovarian Cancer Cell Line
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Park HT, Kim SB, Lee YH, Lee NW, Lee KW, Kim MH, Kim YT
- KMID: 2272091
- Korean J Obstet Gynecol.
- 2003 Jul;46(7):1294-1299.
OBJECTIVE: The chemotherapeutic agent Cisplatin (cis-diammminedichloroplatinum (II)) is particularly effective against ovarian carcinoma, however, its clinical success is limited by recurrent drug resistant tumors. It is mandatory to reveal the... -
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- Effect of glucose on the expression of c-myc gene in cultured RINm5F cell
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Kim SW, Yang IM, Kim JW, Kim YS, Kim KW, Choi YK, Suh KS
- KMID: 1421861
- J Korean Med Sci.
- 1991 Sep;6(3):246-250.
- doi: 10.3346/jkms.1991.6.3.246
The study was designed to examine the effect of glucose on the expression of c-myc gene in cultured RINm5F cells. After monolayer culture was established in RPMI 1640 media supplemented... -
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- Enhanced expression of the c-myc protooncogene in human intracranial meningiomas
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Kim JH, Lee SH, Cho KJ, Jang JJ, Hong SI, Lee JO
- KMID: 1421954
- J Korean Med Sci.
- 1993 Feb;8(1):68-72.
- doi: 10.3346/jkms.1993.8.1.68
We examined the alteration and expression of c-myc protooncogene in 11 human intracranial meningiomas using Southern blot, Northern blot and immunohistochemical techniques. Southern blot showed neither amplification nor rearrangement but... -
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- Correlation between Amplification of c-myc Oncogene and Histophthologic Prognostic Factors in Endomentrial Cancer
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Kim YT, Kim NK, Kim JW
- KMID: 2245018
- Korean J Gynecol Oncol Colposc.
- 1998 Sep;9(3):266-272.
The c-myc oncogene encodes a 62,000 daltons nuclear transcriptional factor and is believed to regulate cellular proliferation. Although its mechanism of action is incompletely understood, oncogene amplification followed by increased... -
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- Immortalization of human embryonic fibroblasts by overexpression of c-myc and simian virus 40 large T antigen
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Kim HS, Shin JY, Yun JY, Ahn DK, Lee JY
- KMID: 1457544
- Exp Mol Med.
- 2001 Dec;33(4):293-298.
SV40 large T antigen, a viral oncoprotein, is known to immortalize human diploid fibroblast by soaking up cellular RB and p53, but its frequency is extremely low. Additional genetic alteration... -
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- Effect on Cell Growth, c-myc mRNA Expression and Telomerase Activity by Transforming Growth Factor-beta1 in Malignant Lymphoma and Leukemia Cell Line
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Li Z, Lee MJ, Jeon HJ, Hong CP, Park CY, Chung CH
- KMID: 1610808
- Korean J Hematol.
- 2005 Sep;40(3):149-158.
- doi: 10.5045/kjh.2005.40.3.149
BACKGROUND: Transforming growth factor-beta1 (TGF-beta1) is known to be a potent growth inhibitor of many cell types, including most epithelial cells. However, the mechanism of TGF-beta1 action on cell growth... -
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- Change of Mad1 Expression in Human Breast Cancer and Normal Breast Tissues
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Han SH, Park KM, Kim HY, Lee MS, Kim HJ, Kim YD
- KMID: 2175222
- J Korean Cancer Assoc.
- 1999 Apr;31(2):267-274.
PURPOSE: Madl protein is known to directly repress Myc target genes and antagonize Myc function. Consequently, Madl is considered to function as a tumor suppressor. We undertook this study to... -
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- Prognostic Significance of Amplification of the c-MYC Gene in Surgically Treated Stage IB-IIB Cervical Cancer
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Kim TJ, Lee A, Lee SJ, Lee WC, Choi YJ, Lee KY, Kang CS
- KMID: 1979062
- Korean J Pathol.
- 2011 Dec;45(6):596-603.
BACKGROUND: Mutations of c-MYC have been described in cervical cancer. However, association between c-MYC gene status and its prognostic significance have not been clarified. METHODS: Tissue microarray sections from 144 patients... -
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- Detection of the c-m c Oncogene Amplification in Ovarian Carcinomas by Differential Polymerase Chain Reaction
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Lyu GS, Park CK, Lee CG, Cho YH, Hwang YY, Lee JD
- KMID: 1979417
- Korean J Pathol.
- 1997 Jul;31(7):644-654.
The amplification of c-myc oncogene was evaluated in 42 cases of ovarian carcinomas to correlate with clinical parameters. Using oligonucleotide primers, sequences from the c-myc exon-3 gene and from a... -
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- Anticancer Effect and Apoptosis of All-trans-retinoic Acid on the Human Ovarian Epithelial Carcinoma Cell Lines
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Han JY, Jung WH, Kim TS
- KMID: 1725666
- Korean J Pathol.
- 2000 Mar;34(3):225-234.
Ovarian carcinoma is a serious disease in women. Some reports revealed all-trans-retinoic acid (tRA) inhibited the proliferation of ovarian carcinoma cell lines and induced apoptosis. The aim of this study... -
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- Inhibition of Cell Growth and Suppression of c-myc Gene Expression by Transforming Growth Factor-beta1 in Cervical Carcinoma Cell Lines
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Kim JW, Kim MR, Kim JH, Kim TE, Park TC, Lee HY, Kim SJ, Namkoong S
- KMID: 2260724
- Korean J Obstet Gynecol.
- 1997 Jan;40(1):154-160.
Transforming growth factor-beta1(TGF-beta1) is known to be a potent growth inhibitor for many cell types, including most epithelial cells. In skin keratinocytes, TGF-beta1 has been shown to inhibit growth and... -
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- UVC induced translocation of protein kinase C (PKC) and expression change of c-myc oncogene in human skin keratinocytes
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Lee IH
- KMID: 1937891
- Korean J Anat.
- 1998 Oct;31(5):799-805.
Recent studies have documented that UVC induced DNA damage leads to activation of protein kinase C (PKC) isoforms, which result in the transient expression of immediate early gene expression, then... -
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- The Expression of ras and myc Oncogene in Transitional Cell Carcinoma of the Urinary Bladder
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Park CS, Juhng BD, Juhng SW, Cho KH
- KMID: 2274839
- Korean J Pathol.
- 1987 Dec;21(4):233-239.
The oncogenes, which have been detected in various human solid tumors, transform culture cells, and the level of m-RNA specific for an oncogene increases in the cellular extract of the... -
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- C-myc Proto-Oncogene Expression and Prognosis in Carcinoma of the Uterine Cervix
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Lee HP, Park CS, Kim JH, Park NH, Song YS, Kang SB
- KMID: 2245128
- Korean J Gynecol Oncol Colposc.
- 1993 Dec;4(4):1-9.
Prognosis in carcinona of the ulerine cervix appears to be influenced by multiple factors (the size of primary tumor, nodal status, deep invasion into cervical stroma, histologic grade etc) that... -
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