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Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors

Kim JH, Choi KY, Lee DJ, Rho YS, Jo SJ

  • KMID: 2278408
  • Clin Exp Otorhinolaryngol.
  • 2014 Mar;7(1):53-58.
OBJECTIVES: To evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors. METHODS: Eighty thyroid tumor cases...
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A Novel Mutation in the Von Hippel-Lindau Tumor Suppressor Gene Identified in a Patient Presenting with Gestational Diabetes Mellitus

Ku YH, Ahn CH, Jung CH, Lee JE, Kim LK, Kwak SH, Jung HS, Park KS, Cho YM

BACKGROUND: Von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited, multisystemic tumor syndrome caused by mutations in the VHL gene. To date, more than 1,000 germline and somatic mutations of...
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Methylation Patterns of Tumor Suppressor Genes in Breast DCIS Tumors

Cho HJ, Ahn CH, Kim JI, Kim KH, Bae JS, Park WC, Song BJ, Jung SS, Kim JS

  • KMID: 2040613
  • J Korean Surg Soc.
  • 2007 Jun;72(6):460-466.
PURPOSE: The methylation of tumor suppressor genes has been implicated in the development of breast cancer. However, the role of methylation in the progression of cancer is still unclear. In...
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Loss of Heterozygosity of Major Tumor Suppressor Genes in Invasive Ductal Carcinomas

Byun WS, Park CH, Cho SJ, Ahn HG, Nam ES, Cha HJ, Kim KS

PURPOSE: Breast cancer is one of the most frequent malignant tumors in Korea. The major tumor suppressor genes (TSGs) such as p16, Rb, E-cadherin and p53 may play important roles...
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Putative Tumor Suppressor Gene Loci onChromosome 20q in Intrahepatic Cholangiocellular Carcinoma that were Found by Microsatellite Marker Analysis

Yoon DS, Park YN, Seo SJ, Ahn SP, Park JS, Chi HS

  • KMID: 2244238
  • Korean J Hepatobiliary Pancreat Surg.
  • 2006 Jun;10(2):29-33.
PURPOSE: Intrahepatic cholangiocellular carcinoma (ICC) is the second most common malignant tumor in the liver, and it arises from epithelial cells in the intrahepatic bile duct. While the reported risk...
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A Clinical Analysis of Methylation Status of Tumor Suppressor Genes in Breast Cancer

Jung H, An CH, Kim KH, Kim JI, Park WC, Song BJ, Jung SS, Lim KW, Kim JS

  • KMID: 2210309
  • J Korean Surg Soc.
  • 2006 Apr;70(4):253-264.
PURPOSE: Aberrant methylation of CpG islands in gene promoters has been considered as a common mechanism for suppressing gene expression in cells. Hypermethylation of CpG islands in promoters is associated...
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Mutational and Loss of Heterozygosity Analysis of the p53 and PTEN Tumor Suppressor Genes in Breast Carcinoma

Suh KS, Lee YH, Na SY, Park MI, Kim HS, Lee SK

  • KMID: 1598229
  • Korean J Pathol.
  • 2005 Oct;39(5):313-319.
BACKGROUND: Although the genetic determinants of most sporadic breast cancers remain unknown, the understanding of the molecular and genetic events that contribute to breast carcinogenesis has been significantly advanced. We...
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The Relationship between PTEN Tumor Suppressor Gene and Vascular Endothelial Growth Factor-Mediated Angiogenesis in Breast Cancer

Park JK, Jung MJ, Chun BK, Hur B

  • KMID: 2275511
  • Korean J Pathol.
  • 2004 Apr;38(2):100-105.
BACKGROUND: PTEN is a novel tumor suppressor gene located at chromosome 10q23.3. Loss of PTEN function has been implicated in the progression of several types of cancer. Angiogenesis is a...
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Multiple Methylator Phenotypes Involving Tumor Suppressor Genes in Ovarian Cancers

Ryu HC, Cho CH, Kwon SH, Park JC, Seo MA, Chung SW, Rhee JH, Kim JI, Yoon SD, Cha SD

  • KMID: 2143469
  • Korean J Gynecol Oncol Colposc.
  • 2003 Sep;14(3):229-234.
OBJECTIVE: Recent evidence suggests that aberrant methylation of CpG islands is a major pathway leading to the inactivation of tumor suppressor genes and development of cancer. The purpose of this...
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Methylation of the p16 tumor suppressor gene in Korean patients with colon cancer and adenoma

Kim DH, Cho M, Kim DH, Joo KR, Park NH, Yang US

  • KMID: 2306037
  • Korean J Med.
  • 2003 Apr;64(4):396-404.
BACKGROUND: De novo methylation and transcriptional silencing of p16 gene is one of the main pathways in inactivation of p16 gene in colon neoplasm. But there has been no study...
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Loss of Heterozygosity and Microsatellite Instability at Multiple Tumor Suppressor Genes in Gastric Carcinomas

Cho YG, Kim CJ, Park CH, Kim YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS

  • KMID: 2372736
  • J Korean Gastric Cancer Assoc.
  • 2003 Dec;3(4):214-220.
PURPOSE: The aim of this study was to investigate the frequency of loss of heterozygosity and the microsatellite instability at multiple tumor suppressor gene loci in gastric adenocarcinomas. MATENRIALS AND METHODS:...
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Relationship between Methylation Status of p16 Tumor Suppressor Gene and Clinicopathologic Behavior of Stomach Cancer

Park CW, Lee DH, Kim JY, Seo SB, Ju HJ, Kim GH, Heo J, Kang DH, Cho M, Yang US

  • KMID: 2143720
  • Korean J Gastroenterol.
  • 2002 Jun;39(6):402-408.
BACKGROUND/AIMS: Hypermethylation of the p16 tumor suppressor gene is one of the most widely reported epigenetic event to occur in the development of human cancers. The authors investigated the methylation...
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Immunohistochemical Study of KAI1, a Tumor Metastasis Suppressor Gene, Expression in Rectal Cancer

Kim IY, Kim SH, Kim JS, Cho MW, Kim DS, Rhoe BS

  • KMID: 1899055
  • J Korean Soc Coloproctol.
  • 2002 Feb;18(1):22-29.
PURPOSE: KAI1/CD82 gene is a recently identified metastasis suppressor gene on human chromosome 11p11.2. Alteration to or reduction of this molecule may allow tumor cells to invade the surrounding tissue...
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Aberrant Methylation of p16 Tumor Suppressor Gene and Death-Associated Protein Kinase in Non-Small Cell Lung Carcinoma

Kim YS, Lee MK, Jung KS, Kim KU, Kim YD, Lee HR, Lee CH, Seok JW, Kim YK, Jun ES, Choi YM, Rha SH, Park SK

BACKGROUND: The p16INK4a (p16) tumor suppressor gene is frequently inactivated in human non-small cell lung cancers (NSCLCs), predominantly through homozygous deletion or in association with aberrant promotor hypermethylation. Death-associated protein...
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Mutations of the p53 tumor suppressor gene in rheumatoid arthritis synovium

Han CW, Kim HK, Kim WY, Lee KW, Ohm EY, Kim JM

  • KMID: 2105712
  • J Korean Orthop Assoc.
  • 2001 Feb;36(1):9-16.
PURPOSE: To analyse the expression of the p53 tumour suppressor gene in the synovial tissue from rheumatoid patients. Material and Methods : Synovial membranes were obtained from 13 patients diagnosed...
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Identification of Tumor Suppressor Gene in Renal Cell Carcinoma using Arbitrarily Primed-Polymease Chain Reaction (AP-PCR)

Gu JH, Park JI, KIm IH, Jung SI, Yoon JH

  • KMID: 1583477
  • Korean J Urol.
  • 2000 Aug;41(8):948-953.
No abstract available.
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A Study on Mutations of p53 Tumor Suppressor Gene in Oral Tumors

Joo SC, Pyo SW

  • KMID: 1961308
  • J Korean Assoc Oral Maxillofac Surg.
  • 2000 Feb;26(1):45-52.
Nowadays, there are a lot of evidence that mutation of the p53 tumor suppressor gene is one of the most common genetic abnormalities in neoplastic progression. In this study, we...
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Genetic alteration of tumor suppressor gene and microsatellite in nonsmall cell lung cancer

Shin TR, Hong YS, Kim JG, Chang JH

BACKGROUND: Lung carcinogenesis is a multistage process involving alterations in multiple genes and diverse pathway. Mutational activation of oncogenes and inactivation of tumor suppressor genes, and subsequent increased genetic instability...
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Genetic Alterations of Tumor Suppressor Genes in Laryngeal Squamous Cell Carcinoma

Min JH, Moon YI, Kim CN, Hong YS, Kim JG

  • KMID: 1874423
  • Korean J Otolaryngol-Head Neck Surg.
  • 2000 Oct;43(10):1094-1101.
BACKGROUND AND OBJECTIVES: Cancer is a genetic disease in which several genetic events are required to induce normal cells to convert to malignancy. Functional loss of tumor suppressor genes is...
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Mutation of p53 and p16 Tumor Suppressor Genes in Cancer and Precancerous Lesions of the Gallbladder

Yoon YB, Kim CY, Kim WH, Kim SW, Kim YT, Ryu JK, Lee WJ

  • KMID: 2084961
  • Korean J Gastroenterol.
  • 1999 Sep;34(3):390-398.
BACKGROUND/AIMS: The purpose of this study was to analyze the frequencies of p53 and p16 gene mutations in gallbladder cancer and precancerous lesions such as dysplasia or adenoma. METHODS: Tissues...
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