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Effects of Repeated Citalopram Treatments on Chronic Mild Stress- Induced Growth Associated Protein-43 mRNA Expression in Rat Hippocampus

Park SH, Choi SH, Lee J, Kang S, Shin YC, Kim HJ, Kim HJ, Shin SK, Lee MS, Shin KH

Although growth associated protein-43 (GAP-43) is known to play a significant role in the regulation of axonal growth and the formation of new neuronal connections in the hippocampus, there is...
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The Effect of Low Energy Laser Irradiation on the Sciatic Nerve Regeneration of the Rat

Hyun JK, Park SG, Lee SJ, Kwon BS

  • KMID: 2136502
  • J Korean Acad Rehabil Med.
  • 2004 Feb;28(1):64-70.
OBJECTIVE: To verify the effect of low energy laser irradiation (LELI) on the regeneration of injured sciatic nerve of the rat by showing the functional improvement and the elevated immunoreactivities...
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Expression of GAP-43 in Rat Facial Motor Neurons According to the Facial Nerve Injury Types

Kim HJ, Rhyu JJ, Cho YB, Ahn KY, Min YI

  • KMID: 2092723
  • Korean J Anat.
  • 2000 Apr;33(2):143-151.
The neuronal phosphoprotein GAP-43 has been implicated in neuritogenesis during developmental stages of the nervous system and in regenerative processes and neuronal plasticity in the adult. It was previously reported...
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Depressed Neuronal Growth Associated Protein (GAP)-43 Expression in the Small Intestines of Mice Experimentally Infected with Neodiplostomum seoulense

Pyo KH, Kang EY, Jung BK, Moon JH, Chai JY, Shin EH

Neodiplostomum seoulense (Digenea: Neodiplostomidae) is an intestinal trematode that can cause severe mucosal pathology in the small intestines of mice and even mortality of the infected mice within 28 days...
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Increase of Synapsin I, Phosphosynapsin (ser-9), and GAP-43 in the Rat Hippocampus after Middle Cerebral Artery Occlusion

Jung YJ, Huh PW, Park SJ, Park JS, Lee KE

  • KMID: 1611228
  • Korean J Physiol Pharmacol.
  • 2004 Apr;8(2):77-81.
The loss of neurons and synaptic contacts following cerebral ischemia may lead to a synaptic plastic modification, which may contribute to the functional recovery after a brain lesion. Using synapsin...
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Hippocampus-dependent Task Improves the Cognitive Function after Ovariectomy in Rats

Cheon S

OBJECTIVES: Estrogen is an important hormone for cell growth, development, and differentiation by transcriptional regulation and modulation of intracellular signaling via second messengers. The reduction in the estrogen level after...
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Differential Expressions of Synaptogenic Markers between Primary Cultured Cortical and Hippocampal Neurons

Kim YG, Lee YI

Primary dissociated neuronal cultures are widely used research tools to investigate of pathological mechanisms and to treat various central and peripheral nervous system problems including trauma and degenerative neuronal diseases....
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Effects of Polychlorinated Biphenyls on the Development of Neuronal Cells in Growth Period; Structure-Activity Relationship

Do Y, Lee DK

Polychlorinated biphenyls (PCBs) are accumulated in our body through food chain and cause a variety of adverse health effects including neurotoxicities such as cognitive deficits and motor dysfunction. In particular,...
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Alterations of the Cerebellar Inhibitory Interneurons and Inhibitory Synapse Following KA-induced Seizures

Lee SY, Lee JH, Won YJ, Yun SY, Hwang SJ, Kim JU, Kim D, Hong HN

  • KMID: 1564267
  • Korean J Anat.
  • 2005 Apr;38(2):153-166.
Most epileptic patients have commonly suffered from recurrent seizures for many years. These seizures are usually associated with inhibitory synaptic reorganization of the hippocampal region, but it is not known...
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Reproductive performance of genetically engineered mice housed in different housing systems

Yadav S, Yadav I, Pratap K, Tiwari PK, Singh VP

The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading...
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Continuous Brain-derived Neurotrophic Factor (BDNF) Infusion After Methylprednisolone Treatment in Severe Spinal Cord Injury

Kim DH, Jahng TA

Although methylprednisolone (MP) is the standard of care in acute spinal cord injury (SCI), its functional outcome varies in clinical situation. Recent report demonstrated that MP depresses the expression of...
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Losartan Prevents Maladaptive Auditory-Somatosensory Plasticity After Hearing Loss via Transforming Growth Factor-β Signaling Suppression

Mun SK, Han KH, Baek JT, Ahn SW, Cho HS, Chang MY

OBJECTIVES: Hearing loss disrupts the balance of auditory-somatosensory inputs in the cochlear nucleus (CN) of the brainstem, which has been suggested to be a mechanism of tinnitus. This disruption results...
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Arrhythmogenic Gene Change and Nerve Sprouting after Acute Myocardial Infarction in Mice

Oh YS, Kim JH, Choi YS, Park HW, Lee DH, Shin WS, Youn HJ, Lee MY, Chung WS, Rho TH, Kim JH, Chen PS, Choi KB

BACKGROUND AND OBJECTIVES: Myocardial infarction (MI) elicits nerve sprouting. However, the time course and spatial distribution of this nerve sprouting and its relationship to the expression of neurotrophic factors is...
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Treadmill Exercise Improves Memory Function Depending on Circadian Rhythm Changes in Mice

Hwang DS, Kwak HB, Ko IG, Kim SE, Jin JJ, Ji ES, Choi HH, Kwon OY

PURPOSE: Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function...
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Is There Additive Therapeutic Effect When GCSF Combined with Adipose-Derived Stem Cell in a Rat Model of Acute Spinal Cord Injury?

Min J, Kim JH, Choi KH, Yoon HH, Jeon SR

OBJECTIVE: Functional and neural tissue recovery has been reported in many animal studies conducted with stem cells. However, the combined effect of cytokines and stem cells has not yet been...
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Animal model evaluation of a novel renal denervation system for future laparoscopic treatment of resistant hypertension

Song WH, Baik J, Yang S, Choi EK, Park SM, Jeong CW

PURPOSE: Although percutaneous catheter-based ablation of renal sympathetic nerve fibers has been used in the treatment of patients with resistant hypertension, a recent phase III study did not confirm its...
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Serotonin (5-HT) Receptor Subtypes Mediate Regulation of Neuromodulin Secretion in Rat Hypothalamic Neurons

Chin C, Kim SI

  • KMID: 2166259
  • Genomics Inform.
  • 2007 Jun;5(2):77-82.
Serotonin (5-HT), the endogenous nonselective 5-HT receptor agonist, activates the inositol -1,4,5- triphosphate / calcium (InsP3/Ca2+) signaling pathway and exerts both stimulatory and inhibitory actions on cAMP production and neuromodulin...
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Effects of Erythropoietin in Hypoxia-Induced Ischemia on Differentiated Human Neuroblastoma SH-SY5Y and Rat Stroke Model

Shin ES, Kim YJ, Kang KA, Lee J, Jeon JY

  • KMID: 2287444
  • Korean J Psychopharmacol.
  • 2010 Jan;21(1):22-28.
OBJECTIVE: The hematopoietic cytokine, erythropoietin (EPO) is known to have neuroprotective effects including promotion of neuronal survival and regeneration after ischemic injury. This study was to investigate the effects of...
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