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Result of Aprotinin and Fibronectin Treatment in Therapy Resistant Corneal Ulcer

Kim EK, Kim HB, Yoon YD, Kim HL

  • KMID: 2107646
  • J Korean Ophthalmol Soc.
  • 1990 Jun;31(6):783-788.
In two patients with chronic corneal ulcer, resistant to conventional therapy, analysis of tear fluid and observation of the corneal state were performed before and after treatment using autologous fibronectin...
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Plasmin and Its Inhibitors in the Lesional Skin of Pemphigus

Lee CW

  • KMID: 2231317
  • Korean J Dermatol.
  • 1988 Jun;26(3):292-297.
The exact pathomechanism of anti-epidermal cell pemphigus antibodies in developing acantholytic changes is unknown. Recent investigations have suggested that pemphigus antibodies, after binding to the antigenic site, induce activation of...
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Studies on Fibrinolytic System Behavior in Women with Polycystic Ovary Syndrome

Yoon TK, Kim YB

  • KMID: 2272118
  • Korean J Obstet Gynecol.
  • 2003 Aug;46(8):1481-1485.
OBJECTIVE: To evaluate the plasma concentration of plasminogen activator inhibitor 1, main regulator of fibrinolytic system in women with polycystic ovary syndrome and to clarify whether it may be involved...
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The Plasmin Activity in Tear Film and Chronic Corneal Ulcer

Yoon YD, Kim HB

  • KMID: 1968196
  • J Korean Ophthalmol Soc.
  • 1991 Oct;32(10):844-849.
Plasmin is an enzyme which plays an important role in the inflammatory process by activating vasoactive amine and lysis of fibrin. On the other hand, plasmin is also known to...
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The Effects of Aprotinin of Experimental Corneal Burn in Rabbits

Kim JC, Moon YS, Lee HK, Shyn KH

  • KMID: 2147847
  • J Korean Ophthalmol Soc.
  • 1992 Nov;33(11):1043-1048.
Recently, many works to treat chronic corneal ulcer have been progressed. It has been reported that the Aprotinin, one of them, is serine protease inhibitor and is useful to treat...
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A Case of a Large Fibrin Clot Formed in a Plama Unit Collected by Donor Plasmapheresis

Kang JW, Seo DH, Oh YC, Lee HJ, Kim SI

  • KMID: 2300133
  • Korean J Blood Transfus.
  • 2000 Dec;11(2):183-187.
A large aggregate was found in a plasma unit collected by plasmapheresis at the Chungbuk Blood Center. The result of the screening test for the donor was normal. The aggregate...
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Acute Renal Failure after Operation Associated with Aprotinin: Report of 3 cases

Kim SC, Eom HS, Ok SY, Kim SI

Aprotinin is a serine protease inhibitor and a powerful antifibrinolytic agent, derived from the inhibition of plasmin and kallikrein. Therefore, it is widely used in cardiopulmonary bypass surgery or major...
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Plasmin System in Placenta from Women with Normal and Preeclamptic Pregnancy

Roh CR, Lee JH, Yoon BK

  • KMID: 2261361
  • Korean J Obstet Gynecol.
  • 1999 Mar;42(3):539-543.
OBJECTIVES: the aim of this study was to evaluate plasmin system in placenta fiom women with normal and preeclamptic pregnancy. METHODS: The levels of urokinase-type plasminogen activator(uPA), tissue-type plasrninogen activator(tPA),...
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Effect of Gabexate Mesilate on Exocrine Secretion of Pancreas in Rats

Choi SK, Kim GT, Park CH, Rew JS, Kim SJ, Yoon CM

  • KMID: 2275045
  • Chonnam Med J.
  • 1997 Jun;33(1):47-54.
Gabexate mesilate is a synthetic compound of 417 daltons that is not antigenic and diffuse easily. Gabexate is a serine protease inhibitor, with effect on trypsin, kallikrein, plasmin and thrombin....
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Elevated levels of activated and inactivated thrombin-activatable fibrinolysis inhibitor in patients with sepsis

Park R, Song J, An SS

BACKGROUND: In sepsis, large scale inflammatory responses can cause extensive collateral damage to the vasculature, because both coagulation and fibrinolysis are activated unevenly. Thrombin-activatable fibrinolysis inhibitor (TAFI) plays a role...
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Alteration of Coagulation and Fibrinolysis in Multiple Trauma

Shin YS, Kim YJ, Park IS, Chi HS

  • KMID: 2206554
  • J Korean Surg Soc.
  • 1999 Aug;57(2):172-179.
BACKGROUND: After multiple trauma, blood coagulation activity is enhanced and fibrinolytic activity is suppressed. Due to high tissue thromboplastin concentration in cerebral tissue, more serious coagulation and fibrinolytic abnormalities may...
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Stromelysin-1 and Membrane type-MMP-1 Expressions in Human Chronic Periodontitis with Type 2 Diabetes Mellitus

Ryu SH, Park JW, Suh JY, Lee JM

PURPOSE: The purposes of this study were to compare and quantify the expression of Stromelysin-1 and MT-MMP-1 in the gingival tissues of patients with type 2 diabetes mellitus(DM) and healthy...
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Comparison of Vitreolytic Effect in Rabbit Eyes: Plasmin, Hyaluronidase, and Their Mixtures

Kim MS, Moon SW, Kim ES, Yu SY, Kwak HW

PURPOSE: The aim of the present study was to quantify and compare the vitreolytic effect of plasmin, hyaluronidase, and a combination of the two. METHODS: Thirty-six rabbits were randomized into 3...
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Efficacy of Autologous Plasmin-Assisted Vitrectomy for Rhegmatogenous Retinal Detachment

Park C, Lee SH, Heo JW, Chung H

PURPOSE: To evaluate the efficacy and complication of autologous plasmin (AP) injected before vitrectomy for rhegmatogenous retinal detachment (RRD). METHODS: Intravitreal AP injection (0.2 ml) was performed on the eyes without...
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Tissue change after embedding gelatin matrix implant(ffibrel) in subcutaneous tissue of rats; histologic, immunohistochemical and scanning electron microscopic study

Kim HJ, Lee CH, Kim KW

  • KMID: 2184119
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 1998 Nov;20(4):341-354.
GMI(Fibrel) is one of the dermal filling substances which have been successfully used for the treatment of depressed cutaneous scar and wrinkles. It's major components are ; Gelatin powder, which...
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Plasma D-dimer Determination in the Diagnosis of Pulmonary Embolism

Lim CM, Kim HK, Choi KH, Lee SD, Koh Y, Kim WS, Jang JS, Kim DS, Kim WD

  • KMID: 2317975
  • Tuberc Respir Dis.
  • 1996 Feb;43(1):69-74.
BACKGROUND: The diagnosis of pulmonary embolism(PE) based on clinical findings is often elusive and therefore requires confirmative diagnostic method. Pulmonary angiography, though the gold standard for the diagnosis of pulmonary...
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Effect of HGF in Invasion of Hypopharyngeal Squamous Cell Carcinoma Cell Line

Kim CH, Moon SK, Bae JH, Lee JH, Choi EC

  • KMID: 2276423
  • Korean J Otolaryngol-Head Neck Surg.
  • 2005 Jun;48(6):788-795.
BACKGROUND AND OBJECTIVES: Recent reports revealed that hepatocyte growth factor (HGF) is related to tumor invasion and metastasis. Activation of the urokinase-type plasminogen activator (u-PA)/plasmin proteolytic network and matrix metalloproteinase...
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The Effects of Gabexate Mesilate on the Ishemia-Reperfusion Injury in the Rabbit Liver

Shin YD, Lee SM, Ko YG, Lee KH, Koh SH, Hong SW, Oh SM

  • KMID: 1895788
  • J Korean Surg Soc.
  • 2001 Dec;61(6):553-559.
PURPOSE: Ischemia-reperfusion is an important pathologic process that leads to impairment of the liver after major surgery. Ischmia-reperfusion injury includes both hypoxia and an inflammatory response associated with reperfusion; the...
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Association Between Plasma Vascular Endothelial Growth Factor, Plasmin System Regulators and Recurrent Early Wheeze

Kim SY, Kwon SM, Park HJ, Kim WT, Kim JK, Choi EJ, Lee KH, Chung HL, Kim SG

  • KMID: 2314569
  • Pediatr Allergy Respir Dis.
  • 2007 Dec;17(4):354-361.
PURPOSE:Vascular endothelial growth factor (VEGF) is known to play an important role in the process of angiogenesis and chronic inflammation. Plasminogen activator inhibitor (PAI)-1 and tissue plasminogen activator (tPA) are...
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Plasminogen Activator Inhibitor-1 Antisense Oligodeoxynucleotides Abrogate Mesangial Fibronectin Accumulation

Park J, Seo JY, Ha H

Excessive extracellular matrix (ECM) accumulation is the main feature of chronic renal disease including diabetic nephropathy. Plasminogen activator inhibitor (PAI)-1 is known to play an important role in renal ECM...
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