Korean J Blood Transfus.  2000 Dec;11(2):183-187.

A Case of a Large Fibrin Clot Formed in a Plama Unit Collected by Donor Plasmapheresis

  • 1Blood Transfusion Research Institute, Korean Red Cross, Seoul, Korea.
  • 2Chungbuk Blood Center, Korean Red Cross, Seoul, Korea.


A large aggregate was found in a plasma unit collected by plasmapheresis at the Chungbuk Blood Center. The result of the screening test for the donor was normal. The aggregate was dissolved in 1N NaOH and 10% SDS and this aggregate was analyzed with UV spectrometer and NMR spectrometer. Most of the component of it was proved to be protein. The informations about this aggregate in plasmapheresis unit were asked to other institutes. Osaka Blood Center of Japanese Red Cross gave an information that the aggregate could be made by anticoagulant. When the aggregate was treated with the plasmin, the aggregate was dissolved completely. And the band regarded as fibrin was found in SDS-PAGE. An aggregate like this could be formed when the amount of anticoagulant is deficient in the collection of blood. To prevent the formation of the fibrin clot, the addition of the proper amount of anticoagulant has to be inspected.


Aggregate; Plasmapheresis; Fibrin clot
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