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Incidence of Scarlet Fever in Children in Jeju Province, Korea, 2002-2016: An Age-period-cohort Analysis

Kim J, Kim JE, Bae JM

OBJECTIVES: Outbreaks of scarlet fever in Mexico in 1999, Hong Kong and mainland China in 2011, and England in 2014-2016 have received global attention, and the number of notified cases...
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Development and Utilization of a Mouse Model of Nasal Polyps

Kim SW, Jeon SY, Kim DW

Systemic corticosteroids currently represent the most effective treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), but their long-term use is constrained due to their detrimental side effects. Until recently, development...
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Elucidating the role of ApxI in hemolysis and cellular damage by using a novel apxIA mutant of Actinobacillus pleuropneumoniae serotype 10

Chang NY, Chen ZW, Chen TH, Liao JW, Lin CC, Chien MS, Lee WC, Lin JH, Hsuan SL

Exotoxins produced by Actinobacillus (A.) pleuropneumoniae (Apx) play major roles in the pathogenesis of pleuropneumonia in swine. This study investigated the role of ApxI in hemolysis and cellular damage using...
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Systemic administration of low dosage of tetanus toxin decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus

Yan BC, Kim IH, Park JH, Ahn JH, Cho JH, Chen BH, Lee JC, Choi JH, Yoo KY, Lee CH, Cho JH, Kim JD, Won MH

  • KMID: 2312107
  • Lab Anim Res.
  • 2013 Sep;29(3):148-155.
In the present study, we investigated the effect of Tetaus toxin (TeT) on cell proliferation and neuroblast differentiation using specific markers: 5-bromo-2-deoxyuridine (BrdU) as an exogenous marker for cell proliferation,...
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Community-Acquired Necrotizing Pneumonia Caused by ST72-SCCmec Type IV-Methicillin-Resistant Staphylococcus aureus in Korea

Hwang JW, Joo EJ, Ha JM, Lee W, Kim E, Yune S, Chung DR, Jeon K

  • KMID: 2320443
  • Tuberc Respir Dis.
  • 2013 Aug;75(2):75-78.
Methcillin-resistant Staphylococcus aureus (MRSA) has emerged as an important cause of community-acquired infections, which has been recently designated as community-associated (CA) MRSA. Panton-Valentine leukocidin (PVL)-negative multilocus sequence type 72 (ST72)-staphylococcal...
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First Imported Case of Skin Infection Caused by PVL-positive ST30 Community-Associated Methicillin-Resistant Staphylococcus aureus Clone in a Returning Korean Traveler from the Philippines

Ko J, Chung DR, Park SY, Baek JY, Kim SH, Kang CI, Peck KR, Lee NY, Song JH

Although pandemic community-associated (CA-) methicillin-resistant Staphylococcus aureus (MRSA) ST30 clone has successfully spread into many Asian countries, there has been no case in Korea. We report the first imported case...
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Characterization of Community-Associated Methicillin-Resistant Staphylococcus aureus in Gwangju, Korea

Kee HY, Kim MJ, Kim SH, Lee SM, Kim SK, Ha DR, Kim ES, Chung JK

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important nosocomial pathogens worldwide. This study was performed to investigate the characterization of MRSA isolated from healthy persons in Gwangju area....
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The Role of Superantigen in Nasal Polypogenesis

Yoon BK, Kim DW

  • KMID: 2132085
  • J Rhinol.
  • 2013 Nov;20(2):88-95.
Superantigens are potent immunostimulatory exotoxins well known to be produced by Staphylococcus aureus (S. aureus). These exotoxins have capacity to act as superantigens by binding with the variable beta(Vbeta) region...
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Profile of Antimicrobial Resistance of Staphylococcus aureus and Molecular Epidemiologic Characterization of Methicillin-resistant Staphylococcus aureus (MRSA) Isolated from Hands of People Using Multitude Facilities

Kim TS, Kim MJ, Kim SH, Kee HY, Seo JJ, Kim ES, Moon YU, Ryu PY, Ha DR

BACKGROUND: The purpose of this study was to investigate perception of hand hygiene and actual hand washing practices of people who used public facilities as well as the presence of...
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A Case of a Submandibular Abscess caused by Panton-Valentine leukocidin Positive USA 300 Community-associated Methicillin Resistant Staphylococcus aureus in a Foreign Resident of South Korea

Jeong D, Bae S, Baek I, Kim S, Kim B, Kwon KT, Ko KS, Lee S

The incidence of community-associated, methicillin-resistant, Staphylococcus aureus (CA-MRSA) has increased in North America and Europe. One of most important reasons is the spread of Panton-Valentine leukocidin (PVL) positive CA-MRSA strains....
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Analysis of Colonization and Genotyping of the Exotoxins of Staphylococcus aureus in Patients with Atopic Dermatitis

Na SY, Roh JY, Kim JM, Tamang MD, Lee JR

BACKGROUND: The skin of atopic dermatitis (AD) patients has a high susceptibility to Staphylococcus aureus colonization, and the toxins produced by S. aureus may aggravate AD by acting as superantigens. OBJECTIVE:...
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Correlation Between the Prevalence of Superantigenic Toxin Genes and Coagulase Serotypes of Staphylococcus aureus Isolates

Kim YG, Lee HS, Kang SK, Chang KS, Hwang SM

A heterogenic group of staphylococcal exotoxins, including staphylococcal superantigenic toxins, enterotoxin (SE), toxic shock syndrome toxin-1 (TSST-1), and coagulase are the most important virulence factors of Staphylococcus aureus. We analyzed...
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Determination of staphylococcal exotoxins, SCCmec types, and genetic relatedness of Staphylococcus intermedius group isolates from veterinary staff, companion animals, and hospital environments in Korea

Youn JH, Koo HC, Ahn KJ, Lim SK, Park YH

The Staphylococcus (S.) intermedius group (SIG) has been a main research subject in recent years. S. pseudintermedius causes pyoderma and otitis in companion animals as well as foodborne diseases. To...
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Vibrio vulnificus Hemolysin Is Easily Inactivated in Spite of Being Produced at High Levels in Cirrhotic Ascites by a fur Mutation

Kim CM, Kim SC, Shin SH

Vibrio vulnificus produces Hemolysin/cytolysin (VvhA), which is one of the most potent exotoxins capable of killing mice at submicrogram levels. However, V. vulnificus growth and vvhA expression are severely repressed...
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Pseudomonas aeruginosa Exotoxin A Reduces Chemoresistance of Oral Squamous Carcinoma Cell via Inhibition of Heat Shock Proteins 70 (HSP70)

Park SR, Lee KD, Kim UK, Gil YG, Oh KS, Park BS, Kim GC

PURPOSE: Oral squamous carcinoma (OSCC) cells exhibit resistance to chemotherapeutic agent-mediated apoptosis in the late stage of malignancy. Increased levels of heat shock proteins 70 (HSP70) in cancer cells are...
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Role of Staphylococcus Aureus Exotoxins in Chronic Rhinosinusitis with Nasal Polyp

Park YK, Seo ST, Kim EH, Kim DH, Choi JW, Kim YM, Rha KS

BACKGROUND AND OBJECTIVES: Staphylococcal exotoxins (SEs) have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyp (CRSwNP). In the current study, we determined the prevalence of specific immunoglobulin...
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Response of Peripheral Blood Mononuclear Cells to Staphylococcus Aureus Exotoxin in Nasal Polyposis

Hwang SH, Kim BG, Kim SW, Cho JH, Shin JH, Kang JM

  • KMID: 2131999
  • J Rhinol.
  • 2010 Nov;17(2):92-96.
BACKGROUND AND OBJECTIVES: Superantigens such as Staphylococcus aureus exotoxin (SE) have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyposis (NP). The aim of this study was to...
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A case of tricuspid valve endocarditis with septic pneumonia caused by methicillin-resistant Staphylococcus aureus in a healthy woman

Park PG, Kang SJ, Park KH, Jung YS, Jung SI, Shin JH, Ko KS

  • KMID: 2081684
  • Korean J Med.
  • 2009 Apr;76(Suppl 1):S199-S203.
Tricuspid valve endocarditis accounts for 5~10% of all cases of infective endocarditis. It commonly occurs in intravenous drug abusers, immunocompromised hosts, and patients with intravenous catheters, burns, or genital sepsis....
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Detection of Staphylococcus Aureus Exotoxins(SEA, TSST-1) in Nasal Polyp with Chronic Rhinosinusitis Patients

Ha J, Gang I, Kim ST

BACKGROUND AND OBJECTIVES: Staphylococcus aureus (S. aureus) exotoxins have been implicated in the pathogenesis of chronic sinusitis with nasal polyp. The aim of this study was to identify the interplay...
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Two Cases of Bacteremia Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus

Kim JH, Kang EJ, Jung YS, Jeon MH, Kim TH, Sin HB, Park SJ, Choo EJ

Recent reports have described an increasing incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in patients who do not exhibit established risk factors for healthcare exposure. We report two cases of...
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