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Spade-Shaped Anastomosis Following a Proximal Gastrectomy Using a Double Suture to Fix the Posterior Esophageal Wall to the Anterior Gastric Wall (SPADE Operation): Case-Control Study of Early Outcomes

Han WH, Eom BW, Yoon HM, Ryu J, Kim YW

PURPOSE: Proximal gastrectomy (PG) is a function-preserving surgery in cases of proximally located early-stage gastric cancer. Because gastroesophageal reflux is a major pitfall of this operation, we devised a modified...
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Long-limb Roux-en-Y Reconstruction after Subtotal Gastrectomy to Treat Severe Diabetic Gastroparesis

Park JM, Kim JW, Chi KC

The role of surgical intervention in patients with diabetic gastroparesis is unclear. We report a case of a 37-year-old man with a history of recurrent episodes of vomiting and long-standing...
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Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease

Kim SY, Jung HK, Lim J, Kim TO, Choe AR, Tae CH, Shim KN, Moon CM, Kim SE, Jung SA

BACKGROUND: Gender-related factors might play an important role in the development of reflux esophagitis (RE) and symptomatic gastro-esophageal reflux disease (GERD). We aimed to evaluate the prevalence and risk factors...
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Prevalence of and Risk Factors for Diseases in Korean Americans and Native Koreans Undergoing Health Checkup

Jo SY, Park H, Lee BK, Baik SJ, Lee HJ, Park YM

BACKGROUND: Korean Americans constitute the fifth largest subgroup in the Asian American population. Despite their increasing population, research and guidelines regarding their health status assessment and disease screening are lacking....
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The Clinical Efficacy of a Pure Alginate Formulation (Lamina G) for Controlling Symptoms in Individuals with Reflux Symptoms: A Randomized Clinical Study

Kim JH, Lee YC, Kim EH, Park JC, Shin SK, Lee SK, Jung DH, Park JJ, Youn YH, Park H

BACKGROUND/AIMS: Bicarbonate-containing alginate formulations are reported to be effective for controlling reflux symptoms. However, the efficacy of Lamina G alginate without gas production has not been reported. The aim is...
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Is the Diagnostic Trial with Proton Pump Inhibitors Reasonable for School Age Children with Gastroesophageal Reflux Symptoms?

Yang J, Lee J, Lee H, Lee J, Youn YM, Choi JH, Kim YJ, Kang HS, Han KH, Kim SH, Kang KS

PURPOSE: On the basis of evidence, we aimed to reevaluate the necessity of the empirical proton pump inhibitor (PPI) trial for children with suspected gastroesophageal reflux disease (GERD). METHODS: We analyzed...
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Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn

Sun YM, Gao Y, Gao F

  • KMID: 2460480
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):515-520.
  • doi: 10.5056/jnm19056
BACKGROUND/AIMS: Recently, esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed, which can increase the diagnostic role of multichannel intraluminal impedance and pH...
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Endoscopic Features of Upper Gastrointestinal Tract in Patients with Systemic Sclerosis Compared to the Healthy Control

Park JW, Kim J, Kang EA, Kim MJ, Kim JS, Lee EB

OBJECTIVE: To characterize the endoscopic features of upper gastrointestinal tract in patients with systemic sclerosis (SSc) compared with those in the healthy controls. METHODS: Data on esophagogastroduodenoscopy (EGD) in 180 patients...
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Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis

Nam SY, Park BJ, Cho YA, Ryu KH

  • KMID: 2433501
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):82-90.
  • doi: 10.5056/jnm18114
BACKGROUND/AIMS: The effect of dietary micronutrients on non-erosive reflux disease (NERD) and reflux esophagitis is unclear. We aim to evaluate the gender-specific effect of micronutrient on erosive esophagitis and NERD. METHODS:...
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Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases

Oshima T, Miwa H

  • KMID: 2417378
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):334-344.
  • doi: 10.5056/jnm18029
Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-related diseases worldwide. However, they have a number of limitations including slow onset of action, influence by...
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A Positive Reflux-Symptom Association Is Not Marked When the Onset of the Reflux Episode Does Not Occur Within the Pre-symptom Time Window

Woodley FW

  • KMID: 2413109
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):324-325.
  • doi: 10.5056/jnm18015
No abstract available.
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Abnormal Gastroesophageal Flap Valve Is Associated With High Gastresophageal Reflux Disease Questionnaire Score and the Severity of Gastroesophageal Reflux Disease in Vietnamese Patients With Upper Gastrointestinal Symptoms

Quach DT, Nguyen TT, Hiyama T

  • KMID: 2413098
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):226-232.
  • doi: 10.5056/jnm17088
BACKGROUND/AIMS: There have been no studies investigating the distribution of abnormal gastroesophageal flap valve (GEFV) among patients with dyspepsia, non-erosive reflux disease (NERD), and reflux esophagitis (RE) in the same...
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Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis

Song IJ, Kim HK, Lee NK, Lee SK

PURPOSE: Patients with gastroesophageal reflux disease without esophagitis show varying responses to proton pump inhibitors (PPIs). The aim of this study was to objectively evaluate the effect of a new...
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The Prevalence of Nontuberculous Mycobacterial Lung Disease with orwithout Reflux Esophagitis

Kang JB, Lee DH, Kwon SH, Kim N, Park YS, Yoon H, Shin CM, Choi YJ

BACKGROUND/AIMS: Gastrointestinal reflux disease (GERD) is defined as ‘a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications’. It is associated with various lung diseases,...
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Prevalence and Epidemiological Characteristics of Endoscopically Proven Reflux Esophagitis in Children in Korea

Yang A, Kang B, Choe JY, Kim HS, Kim K, Choe YH

PURPOSE: The prevalence of reflux esophagitis (RE) has increased recently in Korea. Little is known concerning the prevalence and characteristics of RE in pediatric patients. This study investigated the prevalence...
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The Prevalence and Clinical Features of Non-responsive Gastroesophageal Reflux Disease to Practical Proton Pump Inhibitor Dose in Korea: A Multicenter Study

Park HJ, Park SH, Shim KN, Kim YS, Kim HJ, Han JP, Kim YS, Bang BW, Kim GH, Baik GH, Kim HH, Park SY, Kim SS

BACKGROUND/AIMS: In Korea, there are no available multicenter data concerning the prevalence of or diagnostic approaches for non-responsive gastroesophageal reflux disease (GERD) which does not respond to practical dose of...
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Prevalence and Clinical Characteristics of Noncardiac Chest Pain with Reflux Esophagitis in Korea

Mok JY, Kwon S, Shin K, Oh S, Han S, Eum SH, Kang HJ, Kong BH, Hwang BH, Oh JH

BACKGROUND/AIMS: Noncardiac chest pain (NCCP) is substernal, squeezing chest pain, unrelated to the cardiac problem. Our study aimed to define the prevalence and clinical characteristics of reflux esophagitis in NCCP...
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A Comparison Study of Esophageal Findings on 18F-FDG PET/CT and Esophagogastroduodenoscopy

Jo K, Kim S, Cha J, Hwang SH, Lee N, Yun M, Kang WJ

PURPOSE: The aim of this study was to compare the esophageal findings of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography-computed tomography (18F-FDG PET/CT) and esophagogastroduodenoscopy (EGD). METHODS: We retrospectively reviewed 18F-FDG PET/CT and EGD...
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The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study

Hong SJ, Park SH, Moon JS, Shin WG, Kim JG, Lee YC, Lee DH, Jang JY, Kim JJ, Lee HL, Lee SW, Hwangbo Y, Xu J, Wang B, Xue Z, Liu F, Yuan Y, Leelakusolvong S, Dy F

BACKGROUND/AIMS: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. METHODS: A total of 501 patients with reflux esophagitis were randomized into...
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Sex and Gender Differences in Gastroesophageal Reflux Disease

Kim YS, Kim N, Kim GH

  • KMID: 2433450
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):575-588.
  • doi: 10.5056/jnm16138
It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects...
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