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No More NAFLD: The Term Is Now MASLD

Bae JC

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It Is Time to Understand the Additional Benefits of Active Surveillance for Low-Risk Papillary Thyroid Carcinoma

Kim KJ

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Younger-Onset Diabetes: Is the Age of Onset More Important than the Duration of Diabetes?

Kim MK

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Subacute Thyroiditis in the Time of COVID-19

Ahn HY

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Clinical Implications of Different Thyroid-Stimulating Hormone (TSH) Reference Intervals between TSH Kits for the Management of Subclinical Hypothyroidism

Yoo WS

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The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin

Nijenhuis-Noort EC, Berk KA, Neggers SJCMM, Lely AJvd

This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and...
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A Contemporary Approach to the Diagnosis and Management of Adrenal Insufficiency

Charoensri S, Auchus RJ

Adrenal insufficiency (AI) can be classified into three distinct categories based on its underlying causes: primary adrenal disorders, secondary deficiencies in adrenocorticotropin, or hypothalamic suppression from external factors, most commonly...
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Initial Combination Therapy in Type 2 Diabetes

Kim JY, Kim NH

Type 2 diabetes (T2D) is a progressive disease in which it is challenging to achieve long-term durable glycemic control. However, intensive glycemic control is crucial for preventing diabetes-related complications. Previous...
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Novel and Advanced Ultrasound Techniques for Thyroid Thermal Ablation

Chan WK, Sun JH, Liou MJ, Hsu CJ, Lu YL, Chou WY, Li YR, Liu FH

Thyroid radiofrequency ablation and microwave ablation are widely adopted minimally invasive treatments for diverse thyroid conditions worldwide. Fundamental skills such as the trans-isthmic approach and the moving shot technique are...
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Hypothalamic AMP-Activated Protein Kinase as a Whole-Body Energy Sensor and Regulator

Min SH, Song DK, Lee CH, Roh E, Kim MS

5´-Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a cellular energy sensor, is an essential enzyme that helps cells maintain stable energy levels during metabolic stress. The hypothalamus is pivotal in regulating...
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Efficacy and Safety of Omarigliptin, a Novel Once-Weekly Dipeptidyl Peptidase-4 Inhibitor, in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Kamrul-Hasan A, Alam MS, Talukder SK, Dutta D, Selim S

Background: No recent meta-analysis has holistically analyzed and summarized the efficacy and safety of omarigliptin in type 2 diabetes mellitus (T2DM). We conducted a meta-analysis to address this knowledge gap. Methods:...
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Inhibition of Sodium-Glucose Cotransporter-2 during Serum Deprivation Increases Hepatic Gluconeogenesis via the AMPK/AKT/FOXO Signaling Pathway

Lee J, Hong SW, Kim MJ, Lim YM, Moon SJ, Kwon H, Park SE, Rhee EJ, Lee WY

Background: Sodium-dependent glucose cotransporter 2 (SGLT2) mediates glucose reabsorption in the renal proximal tubules, and SGLT2 inhibitors are used as therapeutic agents for treating type 2 diabetes mellitus. This study...
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Prediction of Cardiovascular Complication in Patients with Newly Diagnosed Type 2 Diabetes Using an XGBoost/GRU-ODE-Bayes-Based Machine-Learning Algorithm

Lee J, Choi Y, Ko T, Lee K, Shin J, Kim HS

Background: Cardiovascular disease is life-threatening yet preventable for patients with type 2 diabetes mellitus (T2DM). Because each patient with T2DM has a different risk of developing cardiovascular complications, the accurate...
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Glucagon: Physiological and Pharmacological Functions and Pathophysiological Significance in Type 2 Diabetes

Kitamura T

Glucagon has many functions, including the promotion of hepatic glucose production, fatty acid oxidation, thermogenesis, energy consumption, lipolysis, and myocardial contraction, as well as the suppression of lipogenesis, appetite, and...
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The Road towards Triple Agonists: Glucagon-Like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide and Glucagon Receptor - An Update

Jakubowska A, Roux CWl, Viljoen A

Obesity is the fifth leading risk factor for global deaths with numbers continuing to increase worldwide. In the last 20 years, the emergence of pharmacological treatments for obesity based on...
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FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation

Kim ME, Lee JS, Kim TW, Park MH, Kim DH

Background: Hepatic steatosis, which involves the excessive accumulation of lipid droplets in hepatocytes, presents a significant global health concern due to its association with obesity and metabolic disorders. Inflammation plays...
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A Narrative Review of the 2023 Korean Thyroid Association Management Guideline for Patients with Thyroid Nodules

Lee EK, Park YJ, Jung CK, Na DG

The 2023 Korean Thyroid Association (KTA) Management Guideline for Patients with Thyroid Nodules constitute an update of the 2016 KTA guideline for thyroid nodules and cancers that focuses specifically on...
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Active Surveillance for Low-Risk Papillary Thyroid Carcinoma as an Acceptable Management Option with Additional Benefits: A Comprehensive Systematic Review

Yoon JH, Choi W, Park JY, Hong AR, Kim HK, Kang HC

Background: Active surveillance (AS) has been introduced as a management strategy for low-risk papillary thyroid carcinoma (PTC) due to its typically indolent nature. Despite this, the widespread adoption of AS...
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Preoperative Serum Copeptin Can Predict Delayed Hyponatremia after Pituitary Surgery in the Absence of Arginine Vasopressin Deficiency

Kang H, Park SS, Kim YH, Lim HS, Lee MK, Lee KR, Kim JH, Kim YH

Background: Delayed postoperative hyponatremia (DPH) is the most common cause of readmission after pituitary surgery. In this study, we aimed to evaluate the cutoff values of serum copeptin and determine...
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Active Surveillance for Low-Risk Thyroid Cancers: A Review of Current Practice Guidelines

Kim MJ, Moon JH, Lee EK, Song YS, Jung KY, Lee JY, Kim Jh, Kim K, Park SK, Park YJ

The indolent nature and favorable outcomes associated with papillary thyroid microcarcinoma have prompted numerous prospective studies on active surveillance (AS) and its adoption as an alternative to immediate surgery in...
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