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Vitamin C Induces Apoptosis in Human Colon Cancer Cell Line, HCT-8 Via the Modulation of Calcium Influx in Endoplasmic Reticulum and the Dissociation of Bad from 14-3-3beta

Kim JE, Kang JS, Lee WJ

It has been reported that vitamin C plays an effective role in the treatment and prevention of cancer, but its specific mechanisms are still largely unknown. The incidence of colon...
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The Development of Early Mouse Embryos Depend on Ca2+ Concentration

Yang JS, Bae IH

  • KMID: 2085143
  • Korean J Fertil Steril.
  • 2000 Sep;27(3):275-282.
OBJECTIVE: This study was to determine the effect of different concentration of calcium in medium on the preimplantational development of zygotes and early 2-cell embryos. METHODS: Female mice of ICR strain...
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Tetanus-induced LTD of Developing MNTB-LSO Synapses in Rat is Dependent on Postsynaptic Ca2+

Ahn SC

  • KMID: 2285329
  • Korean J Physiol Pharmacol.
  • 2007 Jun;11(3):79-84.
Because synaptic refinement of medial nucleus of trapezoid body (MNTB) - lateral superior olive (LSO) synapses is most active during the first postnatal week and the long term depression (LTD)...
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Tetrachloroauric acide depresses the activation processes of phagocytic cells

Lee CS

  • KMID: 1849846
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):377-384.
Gold compounds depress phagocytic cell responses, including chemotaxis, and respiratory burst. However, the effects of gold compounds on the function of phagocytic cells are variable according to the preparation of medicine. In this...
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The Affinity of Calmodulin-Affigel for Inositol Triphosphate Kinase From Bovine Brain

Lim SW, Kim JH

The one event on signaling mechanism is the cleavage by adenyl cyclase of ATP into second messenger, cyclic AMP. The other transfer system of inositol metabolism, it is widely recognized...
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Stationary outward and transient Ca2+-dependent currents in hamster oocytes

Kim YM, Han JH, Kim JS, Hong SG

  • KMID: 1580938
  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):403-408.
The outward currents elicited in hamster eggs by depolarizing pulses were studied. The currents appeared to comprise at least two components, a transient outward component (Ito) and a steady-state outward component (Iinfin). Ito...
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The Effect of Methimazole on the Thyroglobulin Synthesis in Cultured Porcine Thyroid Cells

Lee EJ, Lee HC, Huh KB, Kim KR, Lim SK, Lee KM

  • KMID: 2461527
  • J Korean Soc Endocrinol.
  • 1994 Dec;9(4):332-336.
The thioureylene drugs, propylthiouracil and methylmercaptoimidazol(MMI), exert their antithyroid effect primarily through inhibition of thyroid peroxidase-catalyzed iodination of thyroglobulin. Recently the interest about the effect to the thyroglobulin synthesis of...
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Capsaicin Blocks the Hyperpolarization-Activated Inward Currents via TRPV1 in the Rat Dorsal Root Ganglion Neurons

Kwak J

Capsaicin, the pungent ingredient in hot pepper, activates nociceptors to produce pain and inflammation. However, prolonged exposures of capsaicin will cause desensitization to nociceptive stimuli. Hyperpolarization-activated cation currents (Ih) contribute...
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The Effect of Ghrelin on Ca2+ Concentration in Thyroid FRTL-5 Cells

Kim BJ, Park YJ, Park DJ, So I, Kim KW

  • KMID: 1611346
  • Korean J Physiol Pharmacol.
  • 2004 Aug;8(4):195-200.
Ghrelin is a newly discovered peptide, which is released from the stomach and neurons in the hypothalamic arcuate nucleus (ARC), and potently stimulates growth hormone release and food intake. In...
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Depression of Ca2+ influx in complement C5a-stimulated neutrophils by calmodulin inhibitors

Ham DS, Kim HH, Han ES, Lee CS

  • KMID: 2071531
  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):109-117.
Role of Ca2+/calmodulin complex in intracellular Ca2+ mobilization in neutrophils has not been clearly elucidated. In this study, effects of chlorpromazine, trifluoperazine and imipramine on the intracellular Ca2+ mobilization, including Ca2+ influx, in...
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Changes in the expression of c-myc, RB and tyrosine-phosphorylated proteins during proliferation of NIH 3T3 cells induced by hyaluronic acid

Moon SO, Lee JH, Kim TJ

  • KMID: 754984
  • Exp Mol Med.
  • 1998 Mar;30(1):29-33.
We have shown that hyaluronic acid stimulates the proliferation of quiescent NIH 3T3 cells. We have shown that treatment of 1 mg/ml hyaluronic acid results in increase of tyrosine phosphorylation of two...
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The mechanism of t-butylhydroperoxide-induced apoptosis in IMR-32 human neuroblastoma cells

Kim JA, Lee YS, Huh K

  • KMID: 1917066
  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):19-28.
Apoptosis has been implicated in the pathophysiological mechanisms of various neurodegenerative diseases. In a variety of cell types, oxidative stress has been demonstrated to play an important role in the apoptotic cell death....
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Effects of Ginkgolide B on the Neuronal Excitability of Medial Vestibular Nuclear Neurons in the Rat

Jeong HS, Kim JS, Kim BC, Lim YC, Kim JH, Park JS

  • KMID: 2274969
  • Chonnam Med J.
  • 2002 Sep;38(3):195-201.
This study was designed to investigate the effects of the ginkgolide B on the neuronal excitability ofthe rat vestibular nuclear neurons by whole cell patch clamp technique. When cells were...
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Long-Term Potentiation of Excitatory Synaptic Strength in Spinothalamic Tract Neurons of the Rat Spinal Cord

Hur SW, Park JM

Spinal dorsal horn nociceptive neurons have been shown to undergo long-term synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Here, we focused on the spinothalamic tract (STT) neurons...
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Endothelin-mediated Intracellular Calcium Mobilization in Cultured Bovine Corneal Endothelium

Hahn TW, Cha SH, Lee KH, Kim JH

  • KMID: 2336733
  • J Korean Ophthalmol Soc.
  • 1999 Jan;40(1):31-39.
To investigate the effect of endothelin on intracellular free calcium ([Ca(2+)]i) mobilization and the existence of the endothelin receptor in cultured bovine corneal endothelial cells(BCEC), endothelin-1(ET-1) -induced [Ca(2+)]i increase was...
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Calcium modulates excitatory amino acid (EAA)- and substance P-induced rat dorsal horn cell responses

Shin HK, Kang SH, Chung ID, Kim KS

  • KMID: 1917068
  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):35-45.
Excitatory amino acid (EAA) and substance P (SP) have been known to be primary candidates for nociceptive neurotransmitter in the spinal cord, and calcium ions are implicated in processing of the sensory informations...
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Forward-mode Na+ - Ca2+ exchange during depolarization in the rat ventricular myocytes with high EGTA

Kim EG, Ko CM

  • KMID: 1607137
  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):487-494.
During depolarization, extrusion of Ca2+ from sarcoplasmic reticulum through forward-mode Na+ - Ca2+ exchange was studied in the rat ventricular myocytes patch-clamped in whole-cell configuration. In order to confine the...
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Isolation of Voltage Dependent Calcium Current in Chick Inner Hair Cell

Lee SH, Shin MC, Ahn TH, Kim KY, Kim K, Min HJ, Park CW

BACKGROUND AND OBJECTIVES: Voltage dependent calcium channel (VDCC) mediates calcium ion influx and controls neurotransmitter release in excitable cells. Hair cells in vertebrates cochlea are known to express L-type VDCC....
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Increase of intracellular Ca2+ concentration by Vibrio vulnificus cytolysin in rat platelets; triggering mechanism of platelet cytolysis

Park JB, Chae SW

  • KMID: 1554142
  • Korean J Physiol Pharmacol.
  • 1999 Apr;3(2):199-205.
Vibrio vulnificus cytolysin caused platelet cytolysis and increased intracellular calcium concentration ((Ca2+))i) of rat platelets in a concentration-dependent manner. In the presence of V. vulnificus cytolysin (3 HU/ml), lactate dehydrogenase (LDH) activity was...
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Relationship between sarcoplasmic reticular calcium release and Na+-Ca2+ exchange in the rat myocardial contraction

Kim EG, Kim SJ, Ko CM

  • KMID: 1580806
  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):197-210.
Suppressive role of Na+-Ca2+ exchange in myocardial tension generation was examined in the negative frequency-force relationship (FFR) of electric field stimulated left atria (LA) from postnatal developing rat heart and in the whole-cell...
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