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Role of Efflux Pump Gene adeIJK to Multidrug Resistance in Acinetobacter baumannii Clinical Isolates

Choi JA, Kim CM, Jang SJ, Cho SS, Jang CH, Ko YJ, Kang SH, Park G

BACKGROUND: The emergence of multidrug-resistant Acinetobacter baumannii as a nosocomial pathogen is one of the major public health problems. The aim of this study was to evaluate the role of...
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Hsa-miRNA-143-3p Reverses Multidrug Resistance of Triple-Negative Breast Cancer by Inhibiting the Expression of Its Target Protein Cytokine-Induced Apoptosis Inhibitor 1 In Vivo

Deng YW, Hao WJ, Li YW, Li YX, Zhao BC, Lu D

PURPOSE: Multidrug resistance (MDR) remains a major obstacle in the treatment of triple-negative breast cancer (TNBC) with conventional chemotherapeutic agents. A previous study demonstrated that hsa-miRNA-143-3p plays a vital role...
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Biological and Genetic Characteristics of Clinically Isolated Enterobacter cloacae with Multidrug Resistance

Kim JJ, Koo SH

BACKGROUND: From January 2014 to December 2015, 69 clones of Enterobacter cloacae showing multidrug resistance to six classes of antimicrobial agents were collected from two medical centers in Korea. METHODS: Minimum...
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Multidrug Resistance Mechanisms of Carbapenem Resistant Klebsiella pneumoniae Strains Isolated in Chongqing, China

Yan J, Pu S, Jia X, Xu X, Yang S, Shi J, Sun S, Zhang L

BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little is known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated the phenotypes and MDR...
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Alectinib (CH5424802) antagonizes ABCB1- and ABCG2-mediated multidrug resistance in vitro, in vivo and ex vivo

Yang K, Chen Y, To KK, Wang F, Li D, Chen L, Fu L

Alectinib, an inhibitor of anaplastic lymphoma kinase (ALK), was approved by the Food and Drug Administration (FDA) for the treatment of patients with ALK-positive non-small cell lung cancer (NSCLC). Here...
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Risk factors and molecular epidemiology of community-onset, multidrug resistance extended-spectrum β-lactamase-producing Escherichia coli infections

Park SY, Kang CI, Wi YM, Chung DR, Peck KR, Lee NY, Song JH

BACKGROUND/AIMS: Although multidrug resistance (MDR) among extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) poses significant therapeutic challenges, little is known regarding the risk factors and epidemiology of community-onset MDR-ESBL-EC infections. We performed...
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Spread of Efflux Pump Overexpressing-Mediated Fluoroquinolone Resistance and Multidrug Resistance in Pseudomonas aeruginosa by using an Efflux Pump Inhibitor

Adabi M, Talebi-Taher M, Arbabi L, Afshar M, Fathizadeh S, Minaeian S, Moghadam-Maragheh N, Majidpour

BACKGROUND: Fluoroquinolone resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression and/or target mutations. We designed this study to investigate the efflux pump mediated fluoroquinolone resistance and check...
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Treatment of Neisseria gonorrhoeae in the Era of Multidrug Resistance

Chae JY, Oh MM

Neisseria gonorrhoeae (NG) is becoming increasingly less susceptible to the extended spectrum cephalosporin (ESC), which has been recommended for first-line treatment, and cases of treatment failure are being reported globally....
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Antimicrobial properties of nanomolecules: potential candidates as antibiotics in the era of multi-drug resistance

Kandi V, Kandi S

OBJECTIVES: The emergence of multi-drug resistance among various microbial pathogens has been a cause of serious concern to the medical world, limiting the choice of antibiotics. Considering that it may...
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Unexpected Multidrug Resistance of Methicillin-Resistant Staphylococcus aureus in Urine Samples: A Single-Center Study

Lunacek A, Koenig U, Mrstik C, Radmayr C, Horninger , Plas E

PURPOSE: Infections of methicillin-resistant Staphylococcus aureus (MRSA) are becoming an increasingly concerning clinical problem. The aim of this study was to assess the development of MRSA in urine cultures in...
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Extended-Spectrum beta-Lactamase and Multidrug Resistance in Urinary Sepsis Patients Admitted to the Intensive Care Unit

Kim B, Kim SG, Lee SS, Kim TS, Hwang YI, Jang SH, Kim JH, Jung KS, Park S

BACKGROUND: The role of extended-spectrum beta-lactamase (ESBL)-producing or multidrug-resistant (MDR) organisms in patients with sepsis secondary to urinary traction infection (UTI) has not been investigated extensively in the intensive care...
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Multidrug Resistance in Neisseria gonorrhoeae

Baik S, Lim DH

Gonorrhea, caused by Neisseria gonorrhoeae is the second most prevalent bacterial sexually transmitted infection. The disease causes serious reproductive complications such as pelvic inflammatory disease, ectopic pregnancy, and infertility, and...
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Increases in Doxorubicin Sensitivity and Radioiodide Uptake by Transfecting shMDR and Sodium/Iodide Symporter Gene in Cancer Cells Expressing Multidrug Resistance

Ahn SJ, Lee YJ, Lee YL, Choi CI, Lee SW, Yoo J, Ahn BC, Lee IK, Lee J

  • KMID: 1518943
  • Nucl Med Mol Imaging.
  • 2007 Jun;41(3):209-217.
PURPOSE: Multidrug resistance (MDR) of the cancer cells related to mdr1 gene expression can be effectively treated by selective short hairpin RNA for mdr1 gene (shMDR). Sodium/iodide symporter (NIS) gene...
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A role of Cyclosporine A that suppresses multi-drug resistance (MDR) in the secondary chemotherapy drug resistant cell line of ovarian cancer

An CS, Kim SY, Park CM

  • KMID: 2143513
  • Korean J Gynecol Oncol.
  • 2006 Dec;17(4):286-293.
OBJECTIVE: Resistant, recurrent ovarian cancer patients who had first chemotherapy with Cisplatin have showed low reactivity and high recurrence in the secondary chemotherapy. Therefore, multi-drug resistance (MDR) to chemotherapy is...
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Expression and Function of ABC Transporters as Multidrug Resistance Mechansims in Colon Cancer Cells

Jeong GA, Kim KJ, Min YD, Lee TB, Kang SI, Jung KR, Choi CH

  • KMID: 2101388
  • J Korean Soc Coloproctol.
  • 2005 Jun;21(3):129-137.
PURPOSE: Multidrug resistance (MDR) is a phenomenon whereby tumor cells acquire resistance to a broad range of structurally and functionally diverse chemotherapeutic drugs. The most widely implicated mechanism of MDR...
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Expression and Function of ABC Transporters as Multidrug Resistance Mechansims in Gastric Cancer Cells

Moon SP, Kim KJ, Min YD, Lee TB, Jung KR, Lee JU, Choi CH

  • KMID: 2096248
  • J Korean Surg Soc.
  • 2005 May;68(5):359-366.
PURPOSE: Multidrug resistance (MDR) is a phenomenon whereby tumor cell acquire resistance to a broad range of structurally and functionally diverse chemotherapeutic drugs. The most widely implicated mechanism of MDR...
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The Role of Integrons in the Spread of Multi-drug Resistance

Jang SJ

  • KMID: 2224686
  • Korean J Clin Microbiol.
  • 2005 Apr;8(1):1-9.
The liberal use of antibiotics in human medicine and animal husbandry has promoted the spread of multiple antibiotic resistance. Molecular mechanisms for the acquisition of resistance genes by integron-mediated recombination...
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Comparative Uptake of Tc-99m Sestamibi and Tc-99m Tetrofosmin in Cancer Cells and Tissue Expressing P-Glycoprotein or Multidrug Resistance Associated Protein

Cho JA, Lee J, Yoo JA, Seo JH, Bae JH, Jeong SY, Ahn BC, Sohn SG, Ha JH, Lee K

  • KMID: 1596252
  • Korean J Nucl Med.
  • 2005 Feb;39(1):34-43.
PURPOSE: 99mTc-sestamibi (MIBI) and 99mTc-tetrofosmin have been used as substrates for P-glycoprotein (Pgp) and multidrug resistance associated protein (MRP), which are closely associated with multidrug resistance of the tumors. To...
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Detection of Multidrug Resistance Using Molecular Nuclear Technique

Lee J, Ahn BC

  • KMID: 2078811
  • Korean J Nucl Med.
  • 2004 Apr;38(2):180-189.
Although the outcome of cancer patients after cytotoxic chemotherapy is related diverse mechanisms, multidrug resistance (MDR) for chemotherapeutic drugs due to cellular P-glycoprotein (Pgp) or multidrug-resistance associated protein (MRP) is...
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Significance of Multidrug Resistance (MDR) Activity in Remission Induction & Survival of Acute Myeloid Leukemia

Kim HY, Lee MH, Kim JH, Lee SH, Park J, Kim K, Park QE, Kim WS, Jung CW, Park K

  • KMID: 2038446
  • Korean J Hematol.
  • 2004 Dec;39(4):209-216.
BACKGROUND: The significant improvement in the treatment of adults with acute myeloid leukemia (AML) has been achieved in recent years. However, many patients still fail to achieve a complete remission...
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