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Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster

Park SY, Seo J, Chun YS

BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As...
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Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems

Hong KB, Park Y, Suh HJ

BACKGROUND/OBJECTIVES: The aim of this study was to evaluate the biological and sleep-promoting effects of combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) using caffeine-induced sleepless fruit flies, ICR mice, and...
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Drosophila melanogaster as a Model for Studying Aspergillus fumigatus

AL-Maliki , Martinez S, Piszczatowski P, Bennett JW

Drosophila melanogaster is a useful model organism that offers essential insights into developmental and cellular processes shared with humans, which has been adapted for large scale analysis of medically important...
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Optogenetic Rescue of Locomotor Dysfunction and Dopaminergic Degeneration Caused by Alpha-Synuclein and EKO Genes

Qi C, Varga S, Oh SJ, Lee CJ, Lee D

α-Synuclein (α-Syn) is a small presynaptic protein and its mutant forms (e.g. A53T) are known to be directly associated with Parkinson's disease (PD). Pathophysiological mechanisms underlying α-Syn-mediated neurodegeneration in PD...
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The Synergistic Effects of Antimicrobial Peptides on the Growth Inhibition of Salmonella Typhimurium through Imd Pathway in Drosophila Intestine

Lim YJ, Jo YH, Kim HJ, Park JK

Some Bacillus species present in fermented foods are regarded as probiotics because of their ability to modulate the prevention of some intestinal infections and the modulation of the inflammatory immune...
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Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster

Kim MS

  • KMID: 1502494
  • Biomol Ther.
  • 2013 May;21(3):241-245.
Aging is the single most important risk factor that increases susceptibility to many forms of diseases. As such, much effort has been put forward to elucidate the mechanisms behind the...
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Enhancement of Protein Productivity of Recombinant Hepatitis A Virus VP1 in Stably Transfected Drosophila melanogaster S2 Cells

Jeon HB, Park JH, Lee HH, Kim DH, Lee HY, Shon DH, Kim W, Chung IS

The effect of DMSO and sodium butyrate on the production of recombinant hepatitis A virus (HAV) capsid protein VP1 was evaluated and optimized in the culture of stably transfected Drosophila...
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Dyrk1A Positively Stimulates ASK1-JNK Signaling Pathway during Apoptotic Cell Death

Choi HK, Chung KC

Dual-specificity tyrosine (Y)-phosphorylation-regulated protein kinase 1A (Dyrk1A) is the mammalian homologue of Drosophila melanogaster minibrain and its human gene is mapped to the Down syndrome critical region of chromosome 21....
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Low-dose Gamma-irradiation Effect on Early Stage Development and Lifespan in Various Strains of Drosophila melanogaster

Lee JW, Seong KM, Kim CS, Nam SY, Yang KH, Jin YW

  • KMID: 2075037
  • Korean J Occup Environ Med.
  • 2008 Sep;20(3):225-232.
OBJECTIVES: Although ionizing radiation is recognized as being harmful to humans, debate continues regarding the effects of low doses of ionizing radiation. Some studies have reported that low doses of...
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Activation of B cells using Schneider 2 cells expressing CD40 ligand for the enhancement of antigen presentation in vitro

Yoon SH, Cho HI, Kim TG

  • KMID: 1116202
  • Exp Mol Med.
  • 2005 Dec;37(6):567-574.
CD40 ligand (CD40L) expressed by activated CD4+ T cells is a family member of membrane bound TNF family ligand and its interaction with CD40 expressed in APC has been shown...
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Genomic organization and expression of parkin in Drosophila melanogaster

Bae YJ, Park KS, Kang SJ

  • KMID: 1093612
  • Exp Mol Med.
  • 2003 Oct;35(5):393-402.
We report here the isolation, characterization on genomic structure and expression of the D. melanogaster homolog of human parkin. The 2,122 bp parkin gene sequence contains six exons that form...
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Genomic Organization of ancop Gene for alpha-COP Homolog from Aspergillus nidulans

Lee HH, Chae SK, Kim JY, Maeng PJ, Park HM

  • KMID: 2312327
  • Mycobiology.
  • 2000 Dec;28(4):171-176.
We have cloned a alpha-COP homolog, ancop, from Aspergillus nidulans by colony hybridization of chromosome specific library using alpha-COP homologous fragment as a probe. The probe DNA was amplified with...
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Genetic Toxicity of Ochratoxin A in Chinese Hamster Lung and VERO Cells, ddY Mice, and Drosophila melanogaster

Park CH, Ho HY, Heo OS, Sohn SJ, Han ES, Kim JW, Eom MO, Kim SH, Kim JS, Ha KW

  • KMID: 2099293
  • J Korean Soc Microbiol.
  • 1998 Oct;33(5):441-450.
Ochratoxin A is a natural contaminant of mouldy food and feed, which is produced by Penicillium and Aspergillus, and is suspected of being one of the etiological agents responsible for...
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