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Effects of TGF-beta1 Ribbon Antisense on CCl4-induced Liver Fibrosis

Doh KO

Ribbon-type antisense oligonucleotide to TGF-beta1(TGF-beta1 RiAS) was designed and tested to prevent or resolve the fibrotic changes induced by CCl4 injection. When Hepa1c1c7 cells were transfected with TGF-beta1 RiAS, the...
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Ovarian cancer related gene targeting with large circular antisense library

Doh KO, Chun GS, Sim JC, Yang HS

  • KMID: 2273741
  • Korean J Obstet Gynecol.
  • 2009 Jul;52(7):724-733.
OBJECTIVE: The aim of this study is to find out the genes which are related to ovarian cancer cell growth using large circular antisense library. METHODS: Clones for antisense library were...
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What is the Key Step in Muscle Fatty Acid Oxidation after Change of Plasma Free Fatty Acids Level in Rats?

Doh KO, Suh SD, Kim JY

  • KMID: 1600060
  • Korean J Physiol Pharmacol.
  • 2005 Jun;9(3):173-177.
The purpose of this study was to discern the critical point in skeletal muscle fatty acid oxidation by changing plasma free fatty acids (FFA) level in rat. In the study,...
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Insulin Resistance of Skeletal Muscle was Recovered by Leptin Injection in vivo, but not in vitro, in High-fat Diet Fed Rats

Doh KO, Park JO, Jeon JR, Kim JY

  • KMID: 2285319
  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):125-130.
We examined the effect of leptin on the insulin resistance in skeletal muscles by measuring the glucose transport. Male Wistar rats were fed with chow or high-fat diets for 30...
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Effect of High Fat Diet on Insulin Resistance: Dietary Fat Versus Visceral Fat Mass

Park SY, Kim YW, Kim JY, Jang EC, Doh KO, Lee SK

The purpose of the present study was to determine whether chronic high-fat diet (HF) induces insulin resistance independently of obesity. We randomly divided 40 rats into two groups and fed...
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Differential Effects of Palmitate and Docosahexaenoic acid on ATP-sensitive K+ Channel Activity of Pancreatic beta-cells

Kim YW, Doh KO, Song DK, Bae JH, Park WK, Won KJ, Lee HW, Lee SK

  • KMID: 2063349
  • J Korean Diabetes Assoc.
  • 1999 Dec;23(6):768-776.
BACKGROUND: Elevated levels of free fatty acids markedly enhance insulin secretion. However, dietary polyunsaturated fatty supplementation decrease insulin secretion. The effects of different type of fatty acids on cultured pancreatic...
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Gene Expression Analyses of Mutant Flammulina velutipes (Enokitake Mushroom) with Clogging Phenomenon

Woo JR, Choi DH, Hamza MT, Doh KO, Lee CY, Choo YS, Lee S, Kim JG, Bunch H, Seu YB

Regulation of proper gene expression is important for cellular and organismal survival, maintenance, and growth. Abnormal gene expression, even for a single critical gene, can thwart cellular integrity and normal...
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Change in activity of the sympathetic nervous system in diet-induced obese rats

Park SY, Lee YJ, Kim YW, Kim HJ, Doh KO, Lee MK, Kim JY, Lee SK

We investigated the change in activity of the sympathetic nervous system (SNS) in high-sucrose diet (HSD)-induced obese rats compared with controls. Power spectral analyses of R-R interval variability were performed...
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Effect of Exercise Intensity on Unfolded Protein Response in Skeletal Muscle of Rat

Kim K, Kim YH, Lee SH, Jeon MJ, Park SY, Doh KO

Endoplasmic reticulum (ER) stress, unfolded protein response (UPR), and mitochondrial biogenesis were assessed following varying intensities of exercise training. The animals were randomly assigned to receive either low- (LIT, n=7)...
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