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A Case of Seizure in Diphenhydramine Overdose

Park JS, Kim H, Lee SW

  • KMID: 2101619
  • J Korean Soc Clin Toxicol.
  • 2009 Jun;7(1):23-25.
A 21-year-old woman ingested 1,250 mg of diphenhydramine in a single overdose. Diphenhydramine, a rare ingredient in over-the-counter medication, is used to treat insomnia in Korea. Toxicity is usually limited...
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A Case of Electrocardiographic and Mental Change in a Patient with a Diphenhydramine Overdose

Park CS, Kang IG, Ryu HS, Park SS, Lee MJ, Jeong WJ

  • KMID: 2332762
  • J Korean Soc Emerg Med.
  • 2010 Jun;21(3):405-411.
The antihistaminic drug diphenhydramine is mainly used as a sedative, hypnotic and antiemetic. In many countries it is available over-the-counter, very common, and generally regarded as a harmless drug. However,...
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Cardiac Toxicity Following a Diphenhydramine Overdose

Park SJ, Park JH, Um IK, Park KA, Kim DH, Kim SJ, Lee SW, Hong YS

  • KMID: 2203632
  • J Korean Soc Clin Toxicol.
  • 2011 Jun;9(1):20-25.
PURPOSE: This study was designed to analyze the contributing factors, as well as the incidence and nature of the cardiac toxicity, in patients presenting with diphenhydramine overdose. METHODS: We retrospectively reviewed...
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Oculogyric Crises

Yook KW, Kim MH, Han DK

  • KMID: 1675778
  • J Korean Ophthalmol Soc.
  • 1969 Sep;10(3):29-31.
We obserbed a case of oculogyric crises which developed following an acute barbiturate poisoning. The ocular signs of this patient were quite similar to those of compazine poisoning. Furthermore, benadryl...
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Pressor Effect of Intracerebroventricular Diphenhydramine and Ranitidine in Rabbits

Cho HH, Kim SH, Kang SS, Lee JH, Woo JH

  • KMID: 1954490
  • J Korean Neurosurg Soc.
  • 1991 Nov;20(10-11):905-910.
This study was undertaken to observe the effects of centrally administred antihistamines on the blood pressure. Diphenhydramine(DPH), a H1-receptor antagonist, and ranitidine(RAN), a H2-receptor antagonist were administered intracerebroventricularly(icv) on urethane-anesthetized...
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Candida albicans test for the screening of phototoxicity in anthistamines

Kim TH

  • KMID: 2038867
  • Korean J Dermatol.
  • 1993 Apr;31(2):191-196.
BACKGROUND: Antihistamine drugs are used widely in many conditions. Although some antihistamines may cause a photosensitive reaction,many physicians are not awae of it. OBJECTIVE: For examination of the phototoxic potential of...
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Comparative Analysis of Overdose with Common Sleep-aid Medications: Doxylamine vs Diphenhydramine

Ryu HS, Lee MJ, Park SS, Jeong WJ, Kim HJ

  • KMID: 2203733
  • J Korean Soc Clin Toxicol.
  • 2010 Dec;8(2):79-87.
PURPOSE: The previous studies on H1 antihistamine overdose have generally been limited to cases of acute doxylamine succinate (DS) poisoning, yet there have been some studies on diphenhydramine (DPH) overdosing....
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Anaphylaxis induced by hydroxyethyl starch during general anesthesia: A case report

Kim HJ, Kim SY, Oh MJ, Kim JM

Hydroxyethyl starch (HES) solutions are synthetic non-protein colloid solutions used to treat hypovolemia. However, their use is not free from the risk of allergic reactions. A 42-year-old male was scheduled...
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A case of anaphylactic reaction to oral cefaclor

Kim SH, Choi JH, Ahn Y, Park HS

  • KMID: 2252772
  • Korean J Med.
  • 2003 Nov;65(Suppl 3):S882-S884.
Antibiotics induced anaphylaxis is one of the most acute and potentially fatal drug-related adverse reactions. Cefaclor, an oral second-generation cephalosporin with a beta lactam ring, is used various infectious diseases...
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The Expression of Toll-Like Receptors (TLRs) in Cultured Human Skin Fibroblast is Modulated by Histamine

Jang S, Park JS, Won YH, Yun SJ, Kim SJ

Fibroblasts are responsible for the synthesis and degradation of various connective tissue components and soluble mediators of extracellular matrix metabolism. Few studies have been conducted concerning the expression of toll-like...
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A Clinical Study on Pruritus Due to Intrathecal Morphine

Jeong CJ, Baik SW, Kim IS, Chung KS

Herein is a review of eigthy six surgical cases from March to August, 1986 with recieved tetracaine hrdrochloride spinal anesthesia. In an attempt to relieve postoperative pain, 0.5 mg...
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A Clinical Study on Pruritus Due to Intrathecal Morphine

Jeong CJ, Baik SW, Kim IS, Chung KS

  • KMID: 1946644
  • J Korean Pain Soc.
  • 1988 Jun;1(1):91-97.
Herein is a review of eigthy six surgical cases from March to August, 1986 which recieved tetracaine hydrochloride spinal anesthesia. In an attempt to relieve postoperative pain, 0.5 mg morphine...
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Transfusion Premedication: A Single Center Study

Kim BR, Choi JL, Kim JE, Woo KS, Kim JM, Han JY, Kim KH

  • KMID: 2300001
  • Korean J Blood Transfus.
  • 2013 Aug;24(2):121-127.
BACKGROUND: Acute transfusion reaction occurs during or within a few hours of transfusion with 0.5~3% of blood transfusion. Febrile non-hemolytic transfusion reactions (FNHTRs) and allergic transfusion reactions (ATRs) are the...
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Experimental Study on The Role of Various Antihistaminics to Tissue Mast Cell Changes Elicited by Ultraviolet Ray Inflammation

Houh W, Kim SH

  • KMID: 1683336
  • Korean J Dermatol.
  • 1969 Aug;7(1):9-24.
In order to elucidate the mast cell changes challenged by various antihistaminic preparations and its role to the mast cells challenged by inflammation, male albino rats weighing 120-130gm were used...
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Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations

Kaplan AP

The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H1-receptor blockers are typically employed up to...
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Effects of histamine H|2-receptor stimulation on Mg2+ efflux in perfused guinea pig heart

Kang HS, Chang SE, Kang CW, Chae SW, Kim JS

  • KMID: 2071523
  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):49-54.
Mg2+ is an important regulator of many cardiac functions. However, regulation of intracellular Mg2+ activity in the heart is not well characterized. To assess the effect of histamine H2-receptor stimulation on intracellular Mg2+...
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Prevention of ischemia-reperfusion injury in rat skin island flap: comparison of histamine receptor blocking agents with l-arginine

Seo YK, Kim UK

  • KMID: 2400581
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2006 Jul;28(4):287-294.
Vascular thrombosis and ischemic necrosis still remain the most significant threats to the survival of free flaps. To date, neutrophils have been implicated in the pathogenesis of postischemic injury. Several...
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A case of anaphylactoid reaction to nonionic contrast agent, Iodixanol (Visipaque(R)) during coronary angiography

Choi WW, Cho JS, Kim SC, Kim SH, Ahn Y, Choi JW

  • KMID: 2252697
  • Korean J Med.
  • 2004 Jan;66(1):91-94.
Radiocontrast agent infusion is the most common cause of non-IgE mediated anaphylactoid reaction in the modern medical procedures. The newer lower-osmolar nonionic contrast agents cause significantly lower adverse reactions than...
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Anesthetic Management of Emergent Cesarean Section of a Patient with a Latex-Induced Allergic Reaction: A case report

Kim JT, Ryu HG, Ko H, Lee KH

Since the first report appeared in 1979, the incidence of potentially life threatening allergic reactions to latex has increased. We performed Cesarean section on a 28 yr old women who...
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Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier

Gyawali A, Krol S, Kang YS

Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of...
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