J Korean Soc Clin Toxicol.
2009 Jun;7(1):23-25.
A Case of Seizure in Diphenhydramine Overdose
- Affiliations
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- 1Department of Emergency Medicine,, College of Medicine, Chungbuk National University, Cheongju, Korea. chopin-park@hanmail.net
Abstract
- A 21-year-old woman ingested 1,250 mg of diphenhydramine in a single overdose. Diphenhydramine, a rare ingredient in over-the-counter medication, is used to treat insomnia in Korea. Toxicity is usually limited to anticholinergic symptoms. The standard approach to therapy for the treatment of diphenhydramine overdose is supportive care, including physostigmines and sodium bicarbonates. Here, we review the literature and for the first time report a case of acute diphenhydramine overdosage in Korea, complicated with seizures.
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