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Effects of Di(2-ethylhexyl)phthalate on Bone Metabolism in Ovariectomized Mice

Choi JI, Cho HH

BACKGROUND: The molecular pathways of how endocrine disruptors affect bone mineral density (BMD) and bone remodeling are still unclear. The purpose of this experimental study is to determine the effects...
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Association between urinary phthalate metabolites and obesity in adult Korean population: Korean National Environmental Health Survey (KoNEHS), 2012–2014

Kang Y, Park J, Youn K

BACKGROUND: Phthalate is a chemical that is commonly used as a plasticizer in processing plastic products and as a solvent in personal care products. Although previous experimental studies have reported...
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Low Dose Exposure to Di-2-Ethylhexylphthalate in Juvenile Rats Alters the Expression of Genes Related with Thyroid Hormone Regulation

Kim M, Jeong JS, Kim H, Hwang S, Park IH, Lee BC, Yoon SI, Jee SH, Nam KT, Lim KM

Phthalates widely used in the manufacture of plastics have deeply penetrated into our everyday lives. Recently, a concern over the toxicity of phthalates on thyroid, has been raised but in...
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Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway

Fu Y, Dong J, Wang J, You M, Wei L, Fu H, Wang Y, Chen J

Di-(2-ethylhexyl) phthalate (DEHP) is an ubiquitous environmental contaminant because of its extensive use in plastics and its persistence. As an environmental endocrine disruptor, it is suspected to interfere with neurodevelopment...
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Risk assessment of di(2-ethylhexyl) phthalate in the workplace

Kim HY

OBJECTIVES: A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers. A literature review, consisting of both...
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Phthalate exposure and childhood obesity

Kim SH, Park MJ

Phthalates are commonly used as plasticizers and vehicles for cosmetic ingredients. Phthalate metabolites have documented biochemical activity including activating peroxisome proliferator-activated receptor and antiandrogenic effects, which may contribute to the...
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Ecological Risk Assessment of Chemicals Migrated from a Recycled Plastic Product

Roh JY, Kim MH, Kim WI, Kang YY, Shin SK, Kim JG, Kwon JH

  • KMID: 2380125
  • Environ Health Toxicol.
  • 2013 ;28(1):e2013013.
OBJECTIVES: Potential environmental risks caused by chemicals that could be released from a recycled plastic product were assessed using a screening risk assessment procedure for chemicals in recycled products. METHODS: Plastic...
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Determination of Phthalate Metabolites in Human Serum and Urine as Biomarkers for Phthalate Exposure Using Column-Switching LC-MS/MS

Jeong JY, Lee JH, Kim EY, Kim PG, Kho YL

  • KMID: 2317001
  • Saf Health Work.
  • 2011 Mar;2(1):57-64.
OBJECTIVES: Although phthalates like dibutyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) are commonly used as plasticizers and their metabolites are especially suspected of reproductive toxicity, little is known about occupational...
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Health Risks Assessment in Children for Phthalate Exposure Associated with Childcare Facilities and Indoor Playgrounds

Kim HH, Yang JY, Kim SD, Yang SH, Lee CS, Shin DC, Lim YW

  • KMID: 2380158
  • Environ Health Toxicol.
  • 2011 ;26(1):e2011008.
OBJECTIVES: This study assessed the health risks for children exposed to phthalate through several pathways including house dust, surface wipes and hand wipes in child facilities and indoor playgrounds. METHODS: The...
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Assessment of Di (2-ethylhexyl) Phthalate Exposure by Urinary Metabolites as a Function of Sampling Time

Park MS, Yang YJ, Hong YP, Kim SY, Lee YP

OBJECTIVES: In most DEHP exposure assessment studies, single spot urine sample was used. It could not compare the exposure level among studies. Therefore, we are going to represent the necessity...
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Determination of Serum Di-(2-ethylhexyl) Phthalate and Bisphenol A Level in Children with Idiopathic Central Precocious Puberty

Lee SW, Lee WJ, Chae HW, Lee EB, Kim JH, Kim DH, Kim HS

  • KMID: 2322012
  • J Korean Soc Pediatr Endocrinol.
  • 2009 Dec;14(2):154-162.
PURPOSE: Environmental endocrine disruptors may affect the endocrine system or sexual development in children. Several recent studies have focused on indoor and dietary pollutants such as di-(2-ethylhexyl) phthalate (DEHP), which...
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A Case of Reactive Airways Dysfunction Syndrome in a Synthetic Resin Manufacture Factory

Park SY, Lee JS, Kim BW, Lee JO, Park KC, Choi BS

  • KMID: 2033854
  • Korean J Occup Environ Med.
  • 2008 Dec;20(4):372-378.
BACKGROUND: Reactive airways dysfunction syndrome (RADS), which represents between 5% and 18% of new-onset, work-related asthma, remains underreported in spite of increasing reports of occupational asthma cases through occupational asthma...
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Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes

Baek IJ, Yon JM, Lee SR, Jin Y, Kim MR, Ahn B, Hong JT, Choo YK, Lee BJ, Yun YW, Nam SY

Phospholipid hydroperoxide glutathione peroxidase(PHGPx), an antioxidative selenoprotein, is modulated byestrogen in the testis and oviduct. To examine whetherpotential endocrine disrupting chemicals (EDCs) affectthe microenvironment of the testes, the expression patternsof...
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Validation of High Performance Liquid Chromatographic Method with UV Detector for the Determination of Di(2-ethylhexyl)Phthalate in Plasma in some Korean Male Workers

Yang YJ, Myoung SC, Kim SC, Hong YP

  • KMID: 2075011
  • Korean J Occup Environ Med.
  • 2005 Mar;17(1):70-78.
OBJECTIVES: This study was conducted to validate a simple, rapid and sensitive reverse-phase high-performance liquid chromatographic method with UV detector (HPLC-UV) and present the plasma level of di(2-ethylhexyl)phthalate (DEHP) in...
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An ultrastructural study on cytotoxic effects of mono(2-ethylhexyl) phthalate (MEHP) on testes in Shiba goat in vitro

Andriana B, Tay TW, Maki I, Awal MA, Kanai Y, Kurohmaru , Hayashi Y

  • KMID: 1099837
  • J Vet Sci.
  • 2004 Sep;5(3):235-240.
In this study, the effects of mono(2-ethylhexyl) phthalate (MEHP), one of metabolites of di(2-ethylhexyl) phthalate, on immature Shiba goat testes in vitro were examined. The testes of 2-month-old Shiba goats...
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Age-dependent Effect of Metabolism and Testicular Toxicity to di(2-ethylhexyl) Phthalate

Park YJ, Choi BS, Park JD, Hong YP

  • KMID: 2028183
  • Korean J Occup Environ Med.
  • 2002 Sep;14(3):236-246.
OBJECTIVES: The purpose of this study was to evaluate the age-dependent response of testicular toxicity and the mechanism of di(2-ethylhexyl) phthalate (DEHP) induced testicular toxicity. METHODS: DEHP was administered orally in...
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