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Effect of Vitamin A and E on the Interaction Between 2-Acetylaminofluorene and Rat Liver DNA in Vivo

Hong YS

Binding of the hepatocarcinogen 2-acetylaminofluorene(AAF) to the DNA of rat liver homogenates was examined in vivo. Animals fed low and high concentrations vitamin A and E for 28 days and...
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Relationships among Oxidative Stress Markers, Life Style Factors and Biochemical Findings

Kim YK, Lee DH, Jin SH, Lee WG, Song KE

BACKGROUND: In many studies, oxidative stress markers have been employed to serve as a measure of a disease process or to reflect oxidative status. These oxidative stress markers must have...
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Transcriptional mutagenesis by 8-oxodG in alpha-synuclein aggregation and the pathogenesis of Parkinson's disease

Basu S, Je G, Kim YS

Parkinson's disease (PD) is an age-related progressive neurodegenerative disease associated with selective loss of dopaminergic neurons. The characteristic hallmark of the disease is intracytoplasmic proteinacious inclusion bodies called Lewy bodies,...
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The Changes of Testis and the Effects of Anthocyanin on Spermatogenesis in Rat Induced Varicocele

Jang H, Kim SJ, Yuk SM, Han DS, Ha US, Hong SH, Lee JY, Hwang TK, Hwang SY, Kim SW

PURPOSE: Varicocele is known as a main cause of primary male infertility and it supposed to be associated with oxidative stress. Anthocyanin is known as a natural plant pigment and...
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Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells

Wan J, Bae MA, Song BJ

  • KMID: 755668
  • Exp Mol Med.
  • 2004 Feb;36(1):71-77.
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify...
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Oxidative Stress Levels in Aqueous Humor from High Myopic Patients

Kim EB, Kim HK, Hyon JY, Wee WR, Shin YJ

PURPOSE: To compare oxidative stress status in the aqueous humor of highly myopic eyes and control eyes. METHODS: Aqueous humor samples were collected from 15 highly myopic eyes (high myopia group)...
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Locally delivered antioxidant gel as an adjunct to nonsurgical therapy improves measures of oxidative stress and periodontal disease

Chandra RV, Srinivas G, Reddy AA, Reddy BH, Reddy C, Nagarajan , Naveen A

PURPOSE: The present study has two aims; firstly, it attempts to verify the presence of oxidative stress by estimating the reactive oxygen species (ROS) levels in periodontal pockets > or...
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Health Effect Assessment on Volunteers Involved in the Cleanup Operation Following the Hebei Spirit Oil Spill Along the Taean Coast, Korea

Lee CH, Park KH, Lee MJ, Choi WH, Kim H, Park CH, Kim DS, Yu SD

  • KMID: 1453986
  • Korean J Occup Environ Med.
  • 2010 Mar;22(1):11-19.
OBJECTIVE: The objetive of this study is to assess the level of oxidative stress by the exposure to volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) in volunteers who...
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Effects of Carnitine on Peripheral Blood Mitochondrial DNA Copy Number and Liver Function in Non-Alcoholic Fatty Liver Disease

Lim CY, Jun DW, Jang SS, Cho WK, Chae JD, Jun JH

BACKGROUND/AIMS: Functional and anatomical abnormalities of mitochondria play an important role in developing steatohepatitis. Carnitine is essential for enhanced mitochondrial beta oxidation through the transfer of long-chain fatty acids into...
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The Effect of CpG-Oligodeoxynucleotides with Different Backbone Structures and 3' Hexameric Deoxyriboguanosine Run Conjugation on the Treatment of Asthma in Mice

Chang YS, Kim YK, Kwon HS, Park HW, Min KU, Kim YY, Cho SH

CpG-Oligodeoxynucleotide (ODN) has two backbones. Phosphorothioate backbone (PS) shows a strong immunostimulating effect while phosphodiester (PE) shows little in vivo. 3' hexameric deoxyriboguanosine-run (3' dG6-run) conjugation to PE CpG-ODN has...
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Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression

Kim DH, Cho IH, Kim HS, Jung JE, Kim JE, Lee KH, Park T, Yang YM, Seong SY, Ye SK, Chung MH

  • KMID: 1110126
  • Exp Mol Med.
  • 2006 Aug;38(4):417-427.
To elucidate the roles of 8-hydroxydeoxyguanosine (oh8dG), the nucleoside of 8-hydroxyguanine (oh8Gua), we examined the effects of oh8dG upon LPS-induced intercellular adhesion molecule-1 (ICAM-1) expression and the underlying mechanisms in...
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