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Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma

Xu H, Choe C, Shin SH, Park SW, Kim HS, Jung SH, Yim SH, Kim TM, Chung YJ

Although it has been suggested that kinesin family member 14 (KIF14) has oncogenic potential in various cancers, including hepatocellular carcinoma (HCC), the molecular mechanism of this potential remains unknown. We...
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The micronucleus frequency in cytokinesis-blocked lymphocytes of cattle in the vicinity of a nuclear power plant

Lee HJ, Kang CM, Kim SR, Kim JC, Bae CS, Oh KS, Jo SK, Kim TH, Jang JS, Kim SH

Cytogenetic and hematological analyses were performed on the peripheral blood lymphocytes (PBLs) obtained from Korean native cattle bred in the vicinity of three nuclear power plants (Wolsong, Uljin and Yeonggwang)...
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Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue

Cho MK, An JM, Kim CH, Kang SG

BACKGROUND: Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on...
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Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells

Ndolo KM, Park KR, Lee HJ, Yoon KB, Kim YC, Han SY

Aurora kinase A plays an essential role in mitosis including chromosome separation and cytokinesis. Aberrant expression and activity of Aurora kinase A is associated with numerous malignancies including colorectal cancer...
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Expression of polo-like kinase 1 in pre-implantation stage murine somatic cell nuclear transfer embryos

Moon J, Roh S

Somatic cell nuclear transfer (SCNT) has various applications in research, as well as in the medical field and animal husbandry. However, the efficiency of SCNT is low and the accurate...
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Radioprotective effect of mefenamic acid against radiation-induced genotoxicity in human lymphocytes

Hosseinimehr SJ, Nobakht R, Ghasemi A, Pourfallah TA

PURPOSE: Mefenamic acid (MEF) as a non-steroidal anti-inflammatory drug is used as a medication for relieving of pain and inflammation. Radiation-induced inflammation process is involved in DNA damage and cell...
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