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Expression of beta-catenin in Hepatocellular Carcinoma in Relation to Tumor Cell Proliferation and Cyclin D1 Expression

Joo M, Lee HK, Kang YK

Alteration of beta-catenin expression has been implicated in the development of hepatocellular carcinoma (HCC). It has been also reported that beta-catenin can influence the tumor cell proliferation or cyclin D1...
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Expression of G1 Cell Cycle Regulators in Rat Liver upon Repeated Exposure to Thioacetamide

Kim KT, Han SY, Jeong JS

  • KMID: 760708
  • Korean J Hepatol.
  • 2007 Mar;13(1):81-90.
BACKGROUND/AIMS: Eukaryotic cell cycle is regulated by signal transduction pathways mediated by complexes of cyclin dependent kinases (CDKs) and their partner cyclins, or by interaction with CDK inhibitors. Thioacetamide...
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Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts

Shin SY, Yoon SC, Kim YH, Kim YS, Lee YH

  • KMID: 1121098
  • Exp Mol Med.
  • 2002 Dec;34(6):444-450.
Phospholipase Cgamma1 (PLCgamma1) plays an important role in controlling cellular proliferation and differentiation. PLCgamma1 is overexpressed in some tumors, and its overexpression induces solid tumors in nude mice. However,...
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Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells

Shin SY, Kim CG, Hong DD, Kim JH, Lee YH

  • KMID: 1094083
  • Exp Mol Med.
  • 2004 Aug;36(4):380-386.
The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cell growth, differentiation and apoptosis. Egr-1 has been shown to be down-regulated in many...
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Sulindac Prevents Esophageal Adenocarcinomas Induced by Gastroduodenal Reflux in Rats

Kim SW, Jang TJ, Jung KH, Suh JI

PURPOSE: It is known that cyclooxygenase (COX)-2 expression is increased in Barrett's esophagus and esophageal adenocarcinomas. We studied COX-2 expression and the effect sulindac has on the genesis of...
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Evaluation of expression of the Wnt signaling components in canine mammary tumors via RT² Profiler PCR Array and immunochemistry assays

Yu F, Rasotto R, Zhang H, Pei S, Zhou B, Yang X, Jin Y, Zhang D, Lin D

The Wnt signaling pathway and its key component β-catenin have critical roles in the development of diseases such as tumors in mammals. However, little has been reported about involvement of...
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A Case of Mantle Cell Lymphoma with Meningioma

Kim ES, Goh PG, Kim YJ, Lee SY, Moon HS, Sung JK, Lee BS, Jeong HY

Mantle cell lymphoma (MCL) is an uncommon type of gastrointestinal lymphoma. MCL is a distinct subtype of B-cell non-Hodgkin lymphomas. The major subtype of MCL is characterized by the presence...
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Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of beta-catenin, leading to a rapid proliferation of pancreatic cells

Cho IR, Koh SS, Min HJ, Kim SJ, Lee Y, Park EH, Ratakorn S, Jhun BH, Oh S, Johnston R, Chung YH

It is not yet understood how the enhanced expression of pancreatic adenocarcinoma up-regulated factor (PAUF; a novel oncogene identified in our recent studies), contributes to the oncogenesis of pancreatic cells....
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