- Three Cases of beta-thalassemia in Children with HBB Gene Mutation
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Kang EY, Lee HJ, Choi SI, Park EH, Kim SY, Hwang PH
- KMID: 2279917
- Clin Pediatr Hematol Oncol.
- 2007 Oct;14(2):192-197.
Beta thalassemia is an inherited anemia characterized by decreased or absent synthesis of beta globin chain and known to be uncommon in Korea, but is recently reported more frequently in... -
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- Cloning and Nucleotide Sequence of the aroA Gene from Shigella sonnei KNIH104S
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Park YC, Shin HJ, Hong SG, Hwang SY, Park GD, Ju YR, Lee KJ, Kim YC
- KMID: 1943458
- J Korean Soc Microbiol.
- 1997 Apr;32(2):151-160.
Shigella sonnei is important causes of human enteric infections. S. sonnei KNIH104S was isolated from patient of shigellosis in Korea and previously reported. We cloned 5.2-kb KpnI fragment containing the... -
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- Sequence Analysis of Mitochondrial Genome of Toxascaris leonina from a South China Tiger
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Li K, Yang F, Abdullahi , Song M, Shi X, Wang M, Fu Y, Pan W, Shan F, Chen W, Li G
- KMID: 2367423
- Korean J Parasitol.
- 2016 Dec;54(6):803-807.
- doi: 10.3347/kjp.2016.54.6.803
Toxascaris leonina is a common parasitic nematode of wild mammals and has significant impacts on the protection of rare wild animals. To analyze population genetic characteristics of T. leonina from... -
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- An RNA Mapping Strategy to Identify Ribozyme-Accessible Sites on the Catalytic Subunit of Mouse Telomerase
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Song MS, Lee SW
- KMID: 2166253
- Genomics Inform.
- 2007 Mar;5(1):32-35.
Telomerase reverse transcriptase (TERT) is an enzymatic ribonucleoprotein that prolongs the replicative life span of cells by maintaining protective structures at the ends of eukaryotic chromosomes. Telomerase activity is highly... -
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- Molecular Cloning and Nucleotide Sequence of a Gene Encoding Alcohol Dehydrogenase of Helicobacter pylori
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Rhee KH, Lee WK, Cho MJ, Baik SC, Jeon YS, Choi YJ, Ryu BD, Song JY, Lee IG, Choi SH
- KMID: 2099281
- J Korean Soc Microbiol.
- 1998 Apr;33(2):129-137.
Partially purified H. pylori ADH was used to determine the amino acid sequence of ADH N- terminus. The sequence of the ADH N-terminus was determined as MRVQSKGF. The genomic library... -
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- Control Mechanism for Production and Activation of Helicobacter pylori Urease
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Rhee KH, Lee WK, Cho MJ, Baik SC, Jeon YS, An YS, Choi YJ, Ryu BD, Song JY, Lee IG, Choi SH
- KMID: 2146933
- J Korean Soc Microbiol.
- 1998 Feb;33(1):1-13.
To define the genes for production of catalytically active H. pylori urease, we camed out study to elucidate the structure of urease gene transcript, to delineate the genetic region which... -
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- Detection of Pyrazinamide Resisitance in Mycobacterium Tuberculosis by Sequencing of pncA Gene
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Hwang JY, Kwak KR, Park HK, Lee JS, Park SS, Kim YS, Lee JY, Chang CH, Lee MK, Park SK
- KMID: 2160060
- Tuberc Respir Dis.
- 2001 Jan;50(1):94-105.
- doi: 10.4046/trd.2001.50.1.94
BACKGROUND: Examining the biological susceptibility of Mycobacterium tuberculosis to pyrazinamide (PZA) in vitro is very difficult as PZA is inactive under normal culture conditions. The susceptibility test, an enzyme assay... -
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- Rare PTH Gene Mutations Causing Parathyroid Disorders: A Review
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Lee JH, Davaatseren M, Lee S
- KMID: 2471721
- Endocrinol Metab.
- 2020 Mar;35(1):64-70.
- doi: 10.3803/EnM.2020.35.1.64
Since parathyroid hormone (PTH) was first isolated and its gene (PTH) was sequenced, only eight PTH mutations have been discovered. The C18R mutation in PTH, discovered in 1990, was the... -
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- The Vitamin D Receptor Start Codon Polymorphism (SCP) and Bone Mineral Density in Korean Women
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Chung DJ, Cheon NI, Lee CH, Cho DH, Kang HC, Chung MY, Park JT, Yang SW
- KMID: 2274996
- Chonnam Med J.
- 2001 Sep;37(3):277-283.
Bone mineral density (BMD) is thought to be under strong genetic control. Polymorphisms of the vitamin D receptor (VDR) gene have recently been suggested to account for some of the... -
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- Functional Modification of a Specific RNA with Targeted Trans-Splicing
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Park YH, Kim SC, Kwon BS, Jung HS, Kimm K, Lee SW
- KMID: 1974010
- Genomics Inform.
- 2004 Mar;2(1):45-52.
The self-splicing group I intron from Tetrahymena thermophila has been demonstrated to perform splicing reaction with its substrate RNA in the trans configuration. In this study, we explored the potential... -
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- Diversity of Genetic Environment of bla(CTX-M) Genes and Antimicrobial Susceptibility in Extended-spectrum β-lactamase producing Escherichia coli Isolated in Korea
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Yang YY, Suh MH
- KMID: 2468030
- J Bacteriol Virol.
- 2019 Sep;49(3):95-114.
- doi: 10.4167/jbv.2019.49.3.95
Increasing resistance due to the production of extended-spectrum β-lactamase (ESBL) in Escherichia coli is a major problem to public health and CTX-M enzymes have become the most prevalent ESBL worldwide.... -
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- Hepatitis B Viral Surface Mutations in Patients with Adefovir Resistant Chronic Hepatitis B with A181T/V Polymerase Mutations
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Kim JH, Jung YK, Joo MK, Kim JH, Yim HJ, Park JJ, Kim JS, Bak YT, Yeon JE, Byun KS
- KMID: 1779257
- J Korean Med Sci.
- 2010 Feb;25(2):257-264.
- doi: 10.3346/jkms.2010.25.2.257
The hepatitis B virus (HBV) polymerase gene has overlapping reading frames with surface genes, which allows to alter the amino acid codon of the surface genes. In adefovir (ADV) treated... -
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- Site-Specific Mutagenesis in Human Cells by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives
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Moon KY
- KMID: 2127916
- Cancer Res Treat.
- 2004 Apr;36(2):151-156.
PURPOSE: 7-Bromomethylbenz[a]anthracene is a well- known mutagen and carcinogen. The aim of this study is to determine the mutagenic potency of its two major DNA adducts [N2-(benz[a]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[a]a2G) and N6-(benz[a]anthracen-7-... -
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- Structural Characteristics of Seven IL-32 Variants
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Sohn DH, Nguyen TT, Kim S, Shim S, Lee S, Lee Y, Jhun H, Azam T, Kim J, Kim S
- KMID: 2444156
- Immune Netw.
- 2019 Apr;19(2):e8.
- doi: 10.4110/in.2019.19.e8
IL-32 exists as seven mRNA transcripts that can translate into distinct individual IL-32 variants with specific protein domains. These translated protein domains of IL-32 variants code for specific functions that... -
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- Site-Specific Mutagenesis in Escherichia coli by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives in Double-Stranded or Gapped Plasmids
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Moon KY
- KMID: 1807225
- Cancer Res Treat.
- 2003 Feb;35(1):75-80.
PURPOSE: 7-Bromomethylbenz[alpha]anthracene is a known mutagen and carcinogen. The mutagenic potency of its two major DNA adducts, i.e., N2-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[alpha]a2G) and N6-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyadenosine (b[alpha]a6A), as well as the simpler benzylated analogs,... -
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- Genetic Variation in the Immunoregulatory Gene of Adenovirus Type 3
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Choi EH, Kim HS, Lee HJ
- KMID: 2278925
- Korean J Pediatr Infect Dis.
- 2009 Dec;16(2):199-204.
PURPOSE: Various proteins encoded in the early region 3 (E3) of adenoviruses protect cells from being killed by cytotoxic T cells and death-inducing cytokines. We sought to find out whether... -
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- Characterization and Sequence Analysis of Helicobacter pylori Cryptic Plasmid (pHP489)
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Cho MJ, Song JY, Choi YJ, Lee WK, Baik SC, Ryu BD, Choi SH, Jeon YS, Lee IG, Rhee KH
- KMID: 2146924
- J Korean Soc Microbiol.
- 1998 Aug;33(4):343-352.
The DNA sequence of a plasmid named pHP489 of Helicobacter pylori strain 489 was determined and analyzed to characterize its replication apparatus. The pHP489 plasmid consisted of 1,222 bp and... -
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- Dopa-responsive Dystonia with a Novel Initiation Codon Mutation in the GCH1 Gene Misdiagnosed as Cerebral Palsy
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Lee JH, Ki CS, Kim DS, Cho JW, Park KP, Kim S
- KMID: 1779403
- J Korean Med Sci.
- 2011 Sep;26(9):1244-1246.
- doi: 10.3346/jkms.2011.26.9.1244
Dopa-responsive dystonia (DRD) is a clinical syndrome characterized by childhood-onset dystonia and a dramatic response to relatively low doses of levodopa. However, patients with DRD can be misdiagnosed as cerebral... -
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- CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model
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Lee H, Kim JI, Park JS, Roh JI, Lee J, Kang BC, Lee HW
- KMID: 2459306
- Lab Anim Res.
- 2018 Dec;34(4):279-287.
- doi: 10.5625/lar.2018.34.4.279
Placenta specific 8 (PLAC8, also known as ONZIN) is a multi-functional protein that is highly expressed in the intestine, lung, spleen, and innate immune cells, and is involved in various... -
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- Loss of estrogen receptor-alpha (ER-alpha) and promoter hypermethylation in gastric cancer
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Woo IS, Moon DH, Kim SH, Im SH, Lee MA, Kang JH, Hong YS, Lee KS, Choi MK, Chung IS, Park GS
- KMID: 2252654
- Korean J Med.
- 2004 May;66(5):504-512.
BACKGROUND: The significance of ER expression and hormone manipulation in gastric cancer is not established. There have been several reports supporting the role of the ER gene as tumor suppressor... -
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