- Chromosomal Instability in the Peripheral Blood Lymphocytes of an Ovarian Cancer Patient Undergoing Chemotherapy
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Oh SJ, Moon HS, Huh J
- KMID: 2312210
- Lab Med Online.
- 2012 Oct;2(4):223-225.
Chemotherapy agents can induce chromosomal instability, including a variety of chromatid or chromosomal aberrations. However, only limited data is available on the effect of chemotherapy on the kinetics of chromosomal... -
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- Genomic Instability in Colorectal Cancer; from Bench to Bed
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Lee KY
- KMID: 2334430
- J Korean Soc Coloproctol.
- 2009 Apr;25(2):129-138.
Colorectal cancer is a disease developed by the accumulation of genomic alteration. Two genomic instability pathways, chromosomal instability pathway and microsatellite instability pathway, are known as the main pathways of... -
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- Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential
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Warth A, Herpel E, Krysa S, Hoffmann H, Schnabel P, Schirmacher P, Mechtersheimer G, Blaker H
- KMID: 1123809
- Exp Mol Med.
- 2009 May;41(5):349-353.
- doi: 10.3858/emm.2009.41.5.039
Pulmonary carcinoids are infrequent neoplasms of the lung that normally display a less aggressive biological behavior compared to small cell and non-small cell lung cancers. Approximately 15-25% of carcinoids, in... -
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- Clinical Application of Genetics in Management of Colorectal Cancer
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Kim ER, Kim YH
- KMID: 2174377
- Intest Res.
- 2014 Jul;12(3):184-193.
- doi: 10.5217/ir.2014.12.3.184
The extensive study of genetic alterations in colorectal cancer (CRC) has led to molecular diagnostics playing an increasingly important role in CRC diagnosis and treatment. Currently, it is believed that... -
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- Clinical and Pathological Significance of the Genetic Analysis in Colorectal Carcinomas
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Kim H
- KMID: 1112280
- Korean J Gastroenterol.
- 2004 May;43(5):275-282.
The molecular genetics of colorectal carcinomas are among the best understood of common human cancers. Three inter-related molecular pathways are involved. The chromosomal instability pathway begins with inactivation of the... -
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- Detection of hepatitis B virus DNA and sister chromatid exchange in peripheral bloods from patients with chronic hepatitis B
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Choi WI, Kim DK
- KMID: 2092697
- Korean J Anat.
- 1999 Oct;32(5):629-635.
In the present study author investigated 48 patients with chronic hepatitis B for the presence of peripheral blood HBV-DNA with the aid of DNA molecular techniques. HBV-DNA was detected in... -
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- Triplication of 1q in a Patient with Myelodysplastic Syndrome
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Cho HS, Kim MK, Hyun MS
- KMID: 2252329
- Korean J Hematol.
- 2006 Mar;41(1):56-60.
- doi: 10.5045/kjh.2006.41.1.56
Triplication of 1q is a very rare chromosomal abnormality in hematologic malignancies, and it has been related to Fanconi anemia. The clinical significance of this abnormality is unknown. We report... -
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- Sister Chromatid Exchange Frequencies in Stomach Cancer Patients
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Park CS, Kim DK
- KMID: 2092695
- Korean J Anat.
- 1999 Oct;32(5):615-617.
This study was made to show the effect of stomach cancer on chromosome by sister chromatid exchange (SCE) analysis, because very few studies have reported. Metaphase preparation from peripheral blood... -
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- Classification of Colorectal Cancer Based on Clinical, Morphological and Molecular Features
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Park S
- KMID: 2198868
- J Korean Soc Coloproctol.
- 2008 Dec;24(6):497-504.
- doi: 10.3393/jksc.2008.24.6.497
Colorectal cancer (CRC) has been assumed for many years to be a homogenous condition with the vast majority developing within preexisting-adenomas. However, over the last two-decades, it has become clear... -
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- Epigenetic Alterations and Loss of Imprinting in Colorectal Cancer
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Kim JW
- KMID: 2101396
- J Korean Soc Coloproctol.
- 2005 Jun;21(3):181-190.
Two forms of genomic instability have been described in colorectal cancer: chromosomal (CIN) and microsatellite instability (MIN). Colorectal cancer has been considered to progress through one of these two major... -
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- Chromosomal instability in oral premalignancy
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Kim JS, Kim HJ
- KMID: 2306362
- Korean J Med.
- 1998 Jun;54(6):745-754.
BACKGROUND: Squamous cell carcinoma of the oral cavity was thought to develop through a multistep process driven by genetic changes. Recently, the use of in situ hybridization on paraffin sections... -
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- Screening Relevance of Sessile Serrated Polyps
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Kahi CJ
- KMID: 2449762
- Clin Endosc.
- 2019 May;52(3):235-238.
- doi: 10.5946/ce.2018.112
Conventional adenomas have historically been considered to be the only screening-relevant colorectal cancer (CRC) precursor lesion. The prevailing paradigm was that most CRCs arise along the chromosomal instability pathway, where... -
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- Identification of Target Genes in the Endometrial Carcinomas with Microsatellite Mutator Phenotype
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You KT, Kim H, Park TK, Sohn IS, Lee JY, Jang DW, Yang WG, Kim SN
- KMID: 2272602
- Korean J Obstet Gynecol.
- 2005 May;48(5):1229-1240.
OBJECTIVE: Recent molecular genetic studies have revealed that two major types of genomic instabilities, chromosomal instability and microsatellite instability (MSI), exist in the endometrial carcinomas. Tumors with microsatellite mutator phenotype... -
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- A case of Rothmund-Thomson syndrome
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Kim SH, Shin CH, Yang SW
- KMID: 2278576
- Korean J Pediatr.
- 2006 May;49(5):565-569.
- doi: 10.3345/kjp.2006.49.5.565
Rothmund-Thomson syndrome (RTS), is a rare autosomal recessive disorder, characterized by:skin photosensitivity, poikiloderma, sparse hair, sparse eyebrows/lashes, short stature, skeletal abnormalities, cataracts, and an increased risk of malignancy. Skeletal abnormalities... -
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- Effects of Chromosomal Polyploidy on Survival of Colon Cancer Cells
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Park SU, Choi ES, Jang YS, Hong SH, Kim IH, Chang DK
- KMID: 1128353
- Korean J Gastroenterol.
- 2011 Mar;57(3):150-157.
- doi: 10.4166/kjg.2011.57.3.150
BACKGROUND/AIMS: Tetraploid cells are frequently observed in the inflamed mucosal epithelial cells of the patients with Barrett's esophagus or chronic ulcerative colitis. Polyploidy often occurs during cell fusion, abortive cell... -
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- DNA Methylation Changes in Human Cancers
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Kwon HJ, Kang GH
- KMID: 2244887
- J Genet Med.
- 2009 Jun;6(1):1-7.
Epigenetic changes represented by promoter CpG island hypermethylation and histone modification are an important carcinogenetic mechanism, which is found in virtually all histologic types of human cancer. About 60-70% of... -
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- Epigenetic Changes (Aberrant DNA Methylation) in Colorectal Neoplasia
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Kim YS, Deng G
- KMID: 2284042
- Gut Liver.
- 2007 Jun;1(1):1-11.
Both genetic and epigenetic events have been implicated in the stepwise histological progression involving adenoma-carcinoma and hyperplastic polyp/serrated adenoma-carcinoma sequences in the development of colorectal cancer. Genetic changes have been... -
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- Squamous Cell Carcinoma of Oral Cavity and Metachronously Developed Hepatocellular Carcinoma Arising from Fanconi's Anemia
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Min JS, Park JH, Shin DG, Kim IS
- KMID: 1940514
- J Korean Surg Soc.
- 2006 Feb;70(2):148-152.
Fanconi's anemia (FA) is a rare familiar form of aplastic anemia (AA) that is associated with increased chromosomal instability and defective DNA repair, and it characterized by progressive pancytopenia, skeletal... -
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- Molecular Dimensions of Gastric Cancer: Translational and Clinical Perspectives
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Choi YY, Noh SH, Cheong JH
- KMID: 2211395
- J Pathol Transl Med.
- 2016 Jan;50(1):1-9.
- doi: 10.4132/jptm.2015.09.10
Gastric cancer is a global health burden and has the highest incidence in East Asia. This disease is complex in nature because it arises from multiple interactions of genetic, local... -
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- A Case of Fanconi Anemia Diagnosed by a Chromosome Breakage Test with Skin Fibroblasts
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Lee JJ, Yun KB, Kim SY, Lee MJ, Jung HJ, Park JE, Kim HJ
- KMID: 1485160
- Korean J Hematol.
- 2008 Mar;43(1):62-67.
- doi: 10.5045/kjh.2008.43.1.62
Fanconi anemia is an autosomal recessive disease that's characterized by congenital anomalies, defective hematopoiesis and a high risk of developing acute myeloid leukemia and certain solid tumors. The clinical phenotype... -
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