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Overexpression of Cell Cycle Proteins of Peripheral Lymphocytes in Patients with Alzheimer's Disease

Kim H, Kwon YA, Ahn IS, Kim S, Kim S, Jo SA, Kim DK

OBJECTIVE: Biological markers for Alzheimer's disease (AD) will help clinicians make objective diagnoses early during the course of dementia. Previous studies have suggested that cell cycle dysregulation begins earlier than...
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Alteration of G1/S Cell Cycle Regulatory Proteins in Carcinogenesis of Cutaneous Squamous Cell Carcinomas

Im S, Yoo C, Jung JH, Choi HJ, Yoo J, Kang SJ, Lee KY

BACKGROUND: Aberration of the cell cycle regulatory proteins has been reported to contribute to the development and progression of human malignancy. We studied the expression of G1/S cell cycle regulatory...
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Cellular Effects of Troglitazone on YD15 Tongue Carcinoma Cells

Ta Thi L, Yoo H

An FDA approved drug for the treatment of type II diabetes, Troglitazone (TRO), a peroxisome proliferator–activated receptor gamma agonist, is withdrawn due to severe idiosyncratic hepatotoxicity. In the search for...
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Expression of Cell Cycle Regulatory and Apoptosis-related Proteins in Etoposide-treated Human Skin Fibroblast

Cho JW, Suh MH

  • KMID: 2007130
  • J Korean Cancer Assoc.
  • 2001 Feb;33(1):77-83.
PURPOSE: This study was designed to investigate effect of the etoposide on expression of cell cycle regulatory proteins and apoptosis-related proteins in human skin fibroblast (HSF). MATERIALS AND METHODS: HSF cells...
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Alterations of Cell Cycle Regulation and Apoptosis Related Factors in Skin Tumors

Yang TH, Chang SH, Yoon TY

  • KMID: 2303180
  • Korean J Dermatol.
  • 2001 Jan;39(1):28-38.
BACKGROUND: Tumor growth and progression is dependent on a variety of factors including; increased cell survival, i. e. resistance to undergo apoptosis, increased proliferation, and the inability to undergo growth...
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Effects of Replicative Senescence on the Cell Cycle Regulation in Human Gingival Fibroblasts

Park YC, Yang DS, Kim JH, Kim HA, You YO, You HK, Shin HS

Gingival fibroblasts are major cellular component of gingiva. However, the molecular mechanisms of senescence of human gingival fibroblasts are unknown. Human fibroblasts undergo replicative senescence in vitro after a limited...
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Cell Cycle Regulators as Prognostic Predictor of Colorectal Cancers

Jang SJ

  • KMID: 772708
  • Korean J Gastroenterol.
  • 2004 Dec;44(6):346-349.
No abstract available.
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Effects of DCA on Cell Cycle Proteins in Colonocytes

Ha YH, Park DG

PURPOSE: Evidence that indicates bile acid is a promoter of colon cancer exists. Deoxycholic acid (DCA) modifies apoptosis or proliferation by affecting intracellular signaling and gene expression. However, because previous...
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Retinoic Acid Increases the Cell Cycle Progression of Human Gingival Fibroblasts by Increasing Cyclin E and CDK 2 Expression and Decreasing p21WAF1/CIP1 and p16INK4A Expression

You HK, Seo SJ, Kim KJ, Choi NY, You YO

  • KMID: 1436482
  • Int J Oral Biol.
  • 2012 Sep;37(3):115-120.
Retinoic acid plays an important role in the regulation of cell growth and differentiation. In our present study, we evaluated the effects of all-trans retinoic acid (RA) on cell proliferation...
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Effects of Cyclosporin A on the Cell Cycle Regulation of Human Gingival Fibroblasts

Pi SH, Kim DK, Kim T, You YO, You HK, Shin HS

Cyclosporin A is a cyclic polypeptide produced by the metabolism of fungi. It is widely used at present as immunosuppressive treatment following organ transplants. It is also used to deal...
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Expression of Cell Cycle-Regulatory Proteins in Rectal Cancer: Significance of the Tumor Response to Preoperative Radiochemotherapy and for the Prognosis

Yoo J, Shin JH, Jung JH, Choi HJ, Kang SJ, Kang CS, Lee KY

  • KMID: 2277669
  • Korean J Pathol.
  • 2006 Jun;40(3):217-224.
BACKGROUND: Preoperative radiochemotherapy (PRCT) improves the outcomes for patients suffering with locally advanced rectal carcinoma, compared with surgery alone. However, there are no reliable factors predicting the survival and therapeutic...
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Curcumin Induces Apoptosis and Inhibits Metalloproteinase Activity in Renal Cancer Cell Line

Kim DG, Kwon TK, Park JW, Lee KS

  • KMID: 2292626
  • Korean J Urol.
  • 2002 May;43(5):423-430.
PURPOSE: Curcumin is the major constitute of turmeric powder extracted from the rhizomes of the plant Curcuma longa. We investigated that the effect of curcumin on regulatory protein of cell...
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Expression of Cyclin A and Ki-67 in the Uterine Cervical Carcinoma

Kim MK, Bae DH, Kim CJ

  • KMID: 2244993
  • Korean J Gynecol Oncol Colposc.
  • 1998 Dec;9(4):464-470.
The cell cycle is the set of events that is responsible for the duplication of the cells. Recent studies indicate that cell cycle regulatory proteins, mainly the cyclins and cyclin-related...
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Anticancer Effects of Astaxanthin and alpha-tocopherol in Esophageal Cancer Cell Lines

Lim SA, Lee JY, Jung WH, Lim EH, Joo MK, Lee BJ, Park JJ, Kim JS, Bak YT, Jung SW, Lee SW

BACKGROUND/AIMS: Astaxanthin (AX) has been attributed with potential for protecting the organism against different types of cancer due to its anti-oxidant activity. Also several in vivo and in vitro studies...
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CTCF as a multifunctional protein in genome regulation and gene expression

Kim S, Yu NK, Kaang BK

CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator...
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Alteration of G1/S Cell Cycle Regulatory Proteins in Ovarian Epithelial Tumors

Kim JY, Kim HW, Choi KU, Lee CH, Sol MY, Kang HJ, Shin DH

  • KMID: 2277654
  • Korean J Pathol.
  • 2006 Aug;40(4):274-281.
BACKGROUND: Disturbances of the cell cycle regulatory proteins are key events underlying the development and/or progression of human malignancies. The aim of this study was to evaluate the expression of...
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Relation between Cyclooxygenase-2 and Polo-like Kinase-1 in Non-Small Cell Lung Cancer

Lee KH, Yang SC

  • KMID: 2319250
  • Tuberc Respir Dis.
  • 2009 Oct;67(4):303-310.
BACKGROUND: Elevated expression of cyclooxygenase-2 (COX-2) and Polo-like kinase-1 (PLK-1) is observed in a wide variety of cancers. Augmented expression of COX-2 and enhanced production of prostaglandin E2 (PGE2) are...
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The Changes of Cell Cycle Regulatory Proteins Expression by AdCMVp53 in Cervical Cancer Cell Lines

Jin DG, Lee DH, Seo KY, Kim SY, Huh SW, Bae SM, Kim YW, Lee KH, Lee JM, Namkoong S, Kim CK, Ahn WS

  • KMID: 2272189
  • Korean J Obstet Gynecol.
  • 2003 Nov;46(11):2180-2188.
OBJECTIVE: In this study, we investigated the cell growth inhibition, regulation of cell cycle and induction of apoptosis through recombinant p53 adenoviral vector delivery into cervical cancer cell line SiHa,...
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MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous Carcinoma

Park PE, Jeong JY, Kim SZ, Park JY

  • KMID: 2141002
  • Korean J Pathol.
  • 2013 Oct;47(5):418-425.
BACKGROUND: Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to...
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Effects of Nicotine on the Expression of Cell Cycle Regulatory Proteins of Human Gingival Fibroblasts

Kim T, Kim JH, Pi SH, Kim EC, You YO, You HK, Shin HS

Normal gingival fibroblasts functioning is fundamental for the maintenance of periodontal connective tissue as well as wound healing. Nicotine have been found to affect DNA synthesis and cell proliferation, which...
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