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Obesity and heart failure with preserved ejection fraction: pathophysiology and clinical significance

Lee DY

Obesity is a risk factor for heart failure and cardiovascular disease. Of particular note, over 80% of patients with heart failure with a preserved ejection fraction (HFpEF) are overweight or...
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De-escalation strategies of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention for acute coronary syndrome

Song YB

Antiplatelet therapy is important for reducing systemic and local thrombotic events in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). Antiplatelet treatment regimens, along with dual antiplatelet...
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Targets for rescue from fatty acid-induced lipotoxicity in pancreatic beta cells

Hong SW, Lee WY

A persistent intake of excess calories increases plasma levels of free fatty acids, particularly the saturated form that has been shown to exert toxic effects on pancreatic beta cells by...
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Development of a predictive model for the side effects of liraglutide

Min J, Shinn J, Kim HS

Background: Liraglutide, a drug used for the management of obesity, has many known side effects. In this study, we developed a predictive model for the occurrence of liraglutide-related side effects...
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Effects of exercise on reducing diabetes risk in Korean women according to menopausal status

Cho JH, Kwon HM, Park SE, Yoo JH, Han KD, Rhee EJ, Lee WY

Background: Exercise and estrogen play key roles in preventing diabetes and obesity. Women’s risk of diabetes could increase due to the loss of the protective effect of estrogen after menopause....
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