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Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma

Park HS, Hwang SC, Nahm DH, Yim HE

Toluene diisocyanate (TDI) is the most prevalent agent in occupational asthma (OA) in Korea. The immuno-pathologic mechanism for TDI-induced bronchoconstriction remains to be clarified. We studied the immunohistochemical finding of...
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Monocrotaline-induced pulmonary hypertension correlates with upregulation of connective tissue growth factor expression in the lung

Lee YS, Byun J, Kim JA, Lee JS, Kim KL, Suh YL, Kim JM, Jang HS, Lee JY, Shin IS, Suh W, Jeon ES, Kim DK

  • KMID: 1033098
  • Exp Mol Med.
  • 2005 Feb;37(1):27-35.
Pulmonary hypertension (PH) is characterized by structural and functional changes in the lung including proliferation of vascular smooth muscle cells (VSMCs) and excessive collagen synthesis. Although connective tissue growth factor...
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Comparison of different bronchial closure techniques following pneumonectomy in dogs

Salci H, Bayram AS, Ozyigit Z, Gebitekin , Gorgul OS

The comparison of the histologic healing and bronchopleural fistula (BPF) complications encountered with three different BS closure techniques (manual suture, stapler and manual suture plus tissue flab) after pneumonectomy in...
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Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells

Lee YJ, Lee SH

Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated. In...
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Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model

Kim JE, Koo KH, Kim YH, Sohn J, Park YG

Lung cancer is one of the deadliest and commonly diagnosed neoplasms. Early diagnosis of this disease is critical for improving clinical outcome and prognosis. Because the early stages of lung...
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Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells

Song JS, Cho KS, Yoon HK, Moon HS, Park SH

BACKGROUND: Neutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway...
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