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Culture-Positive Spontaneous Ascitic Infection in Patients with Acute Decompensated Cirrhosis: Multidrug-Resistant Pathogens and Antibiotic Strategies

Liu J, Gao Y, Wang X, Qian Z, Chen J, Huang Y, Meng Z, Lu X, Deng G, Liu F, Zhang Z, Li H, Zheng X

PURPOSE: This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of culture-positive spontaneous ascitic infection (SAI) in patients with acute decompensated cirrhosis. MATERIALS AND METHODS: We retrospectively analyzed 432 acute decompensated...
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Clinical Characteristics and Antimicrobial Susceptibility Trends in Citrobacter Bacteremia: An 11-Year Single-Center Experience

Lee R, Choi SM, Jo SJ, Lee J, Cho SY, Kim SH, Lee DG, Jeong HS

BACKGROUND: Recently, Citrobacter freundii bacteremia outbreak in a neonatal intensive care unit has attracted public attention in Korea. However, Citrobacter bacteremia is uncommon and usually occurs in patients with underlying...
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Differences in Antimicrobial Resistance Phenotypes by the Group of CTX-M Extended-Spectrum β-Lactamase

Gwon B, Yoon EJ, Kim D, Lee H, Shin JH, Shin JH, Shin KS, Kim YA, Uh Y, Kim HS, Kim YR, Jeong SH

BACKGROUND: Escherichia coli and Klebsiella pneumoniae clinical isolates producing CTX-M extendedspectrum β-lactamases (ESBLs) were assessed for antimicrobial resistance phenotypes varied by group of enzymes. METHODS: A total of 1,338 blood isolates,...
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Association between Beta-lactam Antibiotic Resistance and Virulence Factors in AmpC Producing Clinical Strains of P. aeruginosa

Dehbashi S, Tahmasebi , Arabestani MR

OBJECTIVES: The purpose of this study was to determine the presence of IMP and OXA genes in clinical strains of Pseudomonas aeruginosa (P. aeruginosa) that are carriers of the ampC...
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Biological and Genetic Characteristics of Clinically Isolated Enterobacter cloacae with Multidrug Resistance

Kim JJ, Koo SH

BACKGROUND: From January 2014 to December 2015, 69 clones of Enterobacter cloacae showing multidrug resistance to six classes of antimicrobial agents were collected from two medical centers in Korea. METHODS: Minimum...
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Changing trends in clinical characteristics and antibiotic susceptibility of Klebsiella pneumoniae bacteremia

Hyun M, Noh CI, Ryu SY, Kim HA

BACKGROUND/AIMS: Klebsiella pneumoniae is second most common organism of gram-negative bacteremia in Korea and one of the most common cause of urinary tract infection, and intra-abdominal infection. METHODS: We compared clinical...
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Antimicrobial Susceptibility and Clonal Distribution of the Blood Isolates of Pseudomonas aeruginosa from Two Korean Hospitals

Kim CH, Lee JC

An increasing prevalence of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) causes a serious therapeutic problem in clinical setting. This study investigated the antimicrobial susceptibility, resistance mechanisms against...
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Pitfalls of the Clinical and Laboratory Standards Institute’s Revised Breakpoints on Interpretation of the Cephalosporin Susceptibility of an Extended-Spectrum β-lactamase Producing Klebsiella pneumoniae: Analysis of a 2010 Nationwide Proficiency Survey

Won D, Jeong TD, Yoon NS, An D, Kim MN, Kim JQ

  • KMID: 1820222
  • J Lab Med Qual Assur.
  • 2012 Jun;34(1):43-49.
BACKGROUND: In 2010, the Clinical and Laboratory Standards Institute (CLSI) revised the minimum inhibitory concentration (MIC) breakpoints of cephalosporins and aztreonam to exempt extended-spectrum beta-lactamase (ESBL) confirmatory tests for Enterobacteriaceae....
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Characterization of Acinetobacter baumannii Co-producing Carbapenemases OXA-23 and OXA-66, and armA 16S Ribosomal RNA Methylase at a University Hospital in South Korea

Jeong HW, Son BR, Shin DI, Ryu D, Hong SB, Han K, Shin KS

BACKGROUND: In the present study, the resistance mechanisms against carbapenems and aminoglycosides for 23 strains of multi-drug-resistant Acinetobacter baumannii isolated at a university hospital were investigated. METHODS: The minimal inhibitory concentrations...
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Comparison of Clinical and Laboratory Standards Institute and European Committee on Antimicrobial Susceptibility Testing Breakpoints for β-Lactams in Enterobacteriaceae Producing Extended-Spectrum β-Lactamases and/or Plasmid-Mediated AmpC β-Lactamases

Song W, Park MJ, Kim HS, Kim JS, Kim HS, Lee KM

BACKGROUND: In 2010, the Clinical and Laboratory Standards Institute (CLSI) revised breakpoints for cephalosporins and carbapenems and indicated that extended-spectrum beta-lactamase (ESBL) testing is no longer necessary for Enterobacteriaceae. We...
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Antibiotic susceptibility and imaging findings of the causative microorganisms responsible for acute urinary tract infection in children: a five-year single center study

Yoon JE, Kim WK, Lee JS, Shin KS, Ha TS

PURPOSE: We studied the differences in the antibiotic susceptibilities of the microorganisms that causeing urinary tract infections (UTI) in children to obtain useful information on appropriate drug selection for childhood...
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In Vitro Effects of Combined Antibiotics against Multidrug-resistant Pseudomonas aeruginosa

Pai HJ

  • KMID: 2081811
  • Korean J Med.
  • 2010 Jul;79(1):41-47.
BACKGROUND/AIMS: The inhibitory effects of the combination of beta-lactam with ciprofloxacin or amikacin against clinical isolates of multidrug-resistant Pseudomonas aeruginosa were evaluated. METHODS: This study examined ten isolates with variable levels...
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Microbiological spectrum and antibiotic susceptibility pattern in more than 24-month-old children with urinary tract infection: A6-year retrospective, single center experience

Ko JH, Lee JH, Shim EJ, Cho DJ, Min KS, Yoo KY, Lee DH, Kang HJ

PURPOSE: To characterize the pathogens and their antibiotic susceptibilities in more than 24-month-old children with urinary tract infection (UTI) and to study the Escherichia coli antimicrobial susceptibility trend. METHODS: We retrospectively...
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A Case of Multidrug-Resistant Salmonella enterica Serovar Typhi Treated with a Bench to Bedside Approach

Yoon HJ, Cho SH, Kim SH

We report a relapsed case of a 25 year-old man with multi-drug resistant Salmonella serovar Typhi (MDRST) bacteremia who had recently returned from travel in India. Due to unresponsiveness to...
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Evaluation of the Vitek 2 Korean Antimicrobial Susceptibility Testing Cards AST N056 and AST N055

Shin SY, Koo SH, Kwon KC, Park JW, Ko CS, Song JH, Sung JY

BACKGROUND: The recently issued Korean version of antimicrobial susceptibility cards for Vitek 2 system uses an adjusted antimicrobial combination that reflects Korean clinical practice and CLSI guidelines. We evaluated the...
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Epidemiology of Plasmid-Mediated AmpC beta-Lactamase Produced by Clinical Isolates of Klebsiella pneumoniae from Four University Hospitals in Korea

Song W, Kim JS, Lee CH, Lee J, Lee K

  • KMID: 2307591
  • Korean J Nosocomial Infect Control.
  • 2007 Dec;12(2):103-111.
BACKGROUND: Plasmid-mediated AmpC beta-lactamases (PABLs) are cephalosporinases that confer resistance to a wide variety of beta-lactam drugs and that may thereby create serious therapeutic problems. The PABL-producing organisms are a...
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In Vitro Activity of Antimicrobial Combination against Multidrug-Resistant Pseudomonas aeruginosa, Korea

Yoon J, Moon H, Lee M

  • KMID: 2146983
  • Korean J Clin Microbiol.
  • 2006 Apr;9(1):1-6.
BACKGROUND: Pseudomonas aeruginosafrequently causes nosocomial infection. Recently, there have been reports of infection with multidrug-resistant P. aeruginosa. The purpose of this study was to evaluate the in vitro effect of...
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Determination of Genomospecies and Characterization of Antimicrobial Resistance of Multi-drug Resistant Acinetobacter spp. Isolates

Lim YM, Choi TS, Kim J

Acinetobacter species are non-fermentative Gram-negative coccobacilli and they have emerged as important nosocomial pathogens which are associated with the significant multidrug resistance in recent years. Carbapenem-resistant A. baumannii (CRAB) and...
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Antibiotic Sensitivity to the Major Causative Organisms of Acute Urinary Tract Infection in Children

Lee YK, Lee HC, Chun JM, Yoon SY, Lee WG, Shin SM

  • KMID: 1855967
  • Korean J Pediatr.
  • 2005 Jul;48(7):760-765.
PURPOSE: We studied the changes in antibiotic sensitivity to the causative organisms of urinary tract infection (UTI), in order to provide useful information on the choice of adequate drugs in...
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Emergence of CTX-M-9 Extended-Spectrum beta-Lactamase-Producing Enterobacter cloacae Isolates

Hong YR, Yu H, Bae IK, Kwon SB, Jeong SH, Kim HJ, Kim YH, Lee SH

  • KMID: 2224694
  • Korean J Clin Microbiol.
  • 2005 Apr;8(1):57-65.
BACKGROUND: The aim of this study is to assess the prevalence and to investigate the molecular epidemiology of Ambler class A extended-spectrum beta-lactamase (ESBL)-producing Enterobacter cloacae isolates in a university...
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