- Differences in the Adverse Effects of Azathioprine between Inflammatory Bowel Disease and Autoimmune Hepatitis in Korean Patients
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Lee YJ, Choi WY, Park KS, Kim YJ, Cho KB, Kim ES, Jang BK, Chung WJ, Hwang JS
- KMID: 2160667
- Korean J Gastroenterol.
- 2014 Dec;64(6):348-355.
- doi: 10.4166/kjg.2014.64.6.348
BACKGROUND/AIMS: Azathioprine (AZA) has been widely used in the therapy of inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH). However, studies evaluating the adverse effects of AZA in these two... -
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- Successful Azathioprine Treatment with Metabolite Monitoring in a Pediatric Inflammatory Bowel Disease Patient Homozygous for TPMT*3C
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Lee MN, Woo HI, Lee YM, Kang B, Kim JW, Choe YH, Lee SY
- KMID: 1798157
- Yonsei Med J.
- 2013 Nov;54(6):1545-1549.
- doi: 10.3349/ymj.2013.54.6.1545
Thiopurine S-methyltransferase (TPMT) methylates purine analogues, showing TPMT activity in inverse relation to concentrations of active metabolites such as 6-thioguanine nucleotide (6-TGN). With conventional dosing of thiopurines, patients with homozygous... -
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