- Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-XL
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Woo KM, Kim HM, Ko JS
- KMID: 755205
- Exp Mol Med.
- 2002 Nov;34(5):340-346.
Macrophage colony-stimulating factor (M-CSF) is known as one of the factors essential for osteoclast development. In the present study, we examined effects of M-CSF on the apoptotic pathway of osteoclast... -
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- Withaferin A-Caused Production of Intracellular Reactive Oxygen Species Modulates Apoptosis via PI3K/Akt and JNKinase in Rabbit Articular Chondrocytes
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Yu SM, Kim SJ
- KMID: 2129597
- J Korean Med Sci.
- 2014 Aug;29(8):1042-1053.
- doi: 10.3346/jkms.2014.29.8.1042
Withaferin A (WFA) is known as a constituent of Ayurvedic medicinal plant, Withania somnifera, and has been used for thousands of years. Although WFA has been used for the treatment... -
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- A Novel Synthetic Compound 3-Amino-3-(4-Fluoro-Phenyl)-1H-Quinoline-2,4-Dione (KR22332) Exerts a Radioprotective Effect via the Inhibition of Mitochondrial Dysfunction and Generation of Reactive Oxygen Species
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Baek SJ, Chang JW, Park KH, Yang GY, Hwang HS, Koh YW, Jung YS, Kim CH
- KMID: 2130811
- Yonsei Med J.
- 2014 Jul;55(4):886-894.
- doi: 10.3349/ymj.2014.55.4.886
PURPOSE: Acute side effects of radiation such as oral mucositis are observed in most patients. Although several potential radioprotective agents have been proposed, no effective agent has yet been identified.... -
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- Effect of Advanced Glycation End Products on Oxidative Stress and Senescence of Trabecular Meshwork Cells
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Park CH, Kim JW
- KMID: 1364866
- Korean J Ophthalmol.
- 2012 Apr;26(2):123-131.
- doi: 10.3341/kjo.2012.26.2.123
PURPOSE: To investigate the effect of advanced glycation end products (AGE) on oxidative stress and cellular senescence in cultured human trabecular meshwork cells (HTMC). METHODS: Primarily cultured HTMC were exposed to... -
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- The Levels of MDM2 Protein Are Decreased by a Proteasome-Mediated Proteolysis Prior to Caspase-3-Dependent pRb and PARP Cleavages
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Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH
- KMID: 648246
- J Korean Med Sci.
- 2001 Apr;16(2):135-139.
- doi: 10.3346/jkms.2001.16.2.135
MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a... -
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- An ultrastructural study on cytotoxic effects of mono(2-ethylhexyl) phthalate (MEHP) on testes in Shiba goat in vitro
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Andriana B, Tay TW, Maki I, Awal MA, Kanai Y, Kurohmaru , Hayashi Y
- KMID: 1099837
- J Vet Sci.
- 2004 Sep;5(3):235-240.
In this study, the effects of mono(2-ethylhexyl) phthalate (MEHP), one of metabolites of di(2-ethylhexyl) phthalate, on immature Shiba goat testes in vitro were examined. The testes of 2-month-old Shiba goats... -
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- Proliferation of Toxoplasma gondii Suppresses Host Cell Autophagy
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Lee YJ, Song HO, Lee YH, Ryu JS, Ahn MH
- KMID: 1715701
- Korean J Parasitol.
- 2013 Jun;51(3):279-287.
- doi: 10.3347/kjp.2013.51.3.279
Autophagy is a process of cytoplasmic degradation of endogenous proteins and organelles. Although its primary role is protective, it can also contribute to cell death. Recently, autophagy was found to... -
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- The Role of Nitric Oxide in Ocular Surface Cells
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Kim JC, Park GS, Kim JK, Kim YM
- KMID: 1101556
- J Korean Med Sci.
- 2002 Jun;17(3):389-394.
- doi: 10.3346/jkms.2002.17.3.389
The role of nitric oxide (NO) in the ocular surface remains unknown. We investigated the conditions leading to an increase of NO generation in tear and the main sources of... -
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