- Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
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Lee J, Hong EM, Jang JA, Park SW, Koh DH, Choi MH, Jang HJ, Kae SH
- KMID: 2363978
- Gut Liver.
- 2016 Mar;10(2):310-317.
- doi: 10.5009/gnl15195
BACKGROUND/AIMS: Statins act as antineoplastic agents through the inhibition of cell proliferation. This study sought to demonstrate the effects of statins on extrahepatic bile duct cancer cell apoptosis and to... -
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- Cytomegalovirus Ventriculoencephalitis after Unrelated Double Cord Blood Stem Cell Transplantation with an Alemtuzumab-containing Preparative Regimen for Philadelphia-positive Acute Lymphoblastic Leukemia
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Lee S, Kim SH, Choi SM, Lee DG, Kim SY, Lee JW, Min WS, Shin WS, Kim CC
- KMID: 1792937
- J Korean Med Sci.
- 2010 Apr;25(4):630-633.
- doi: 10.3346/jkms.2010.25.4.630
Despite the prophylaxis and preemptive strategies using potent antiviral agents, cytomegalovirus (CMV) remains a major infectious cause of morbidity and mortality in allogeneic stem cell transplantation (SCT) recipients. Delayed immune... -
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- Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappa B activation
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Lee KY, Park JS, Jee YK, Rosen GD
- KMID: 1121100
- Exp Mol Med.
- 2002 Dec;34(6):462-468.
TNF-related apoptosis-inducing ligand (TRAIL/Apo- 2L), a newly identified member of the TNF family promotes apoptosis by binding to the transmembrane receptors (TRAIL-R1/DR4 and TRAIL-R2/ DR5). TRAIL known to activate... -
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- Prostaglandin E2 and Interleukin-1beta Reduce E-cadherin Expression by Enhancing Snail Expression in Gastric Cancer Cells
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Jee YS, Jang TJ, Jung KH
- KMID: 1782129
- J Korean Med Sci.
- 2012 Sep;27(9):987-992.
- doi: 10.3346/jkms.2012.27.9.987
Inflammation is closely related to the progression of cancer as well as tumorigenesis. Here, we investigated the effect of prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta) on E-cadherin expression in SNU719... -
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- Troglitazone Enhances the Apoptotic Response of DLD-1 Colon Cancer Cells to Photodynamic Therapy
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Park H, Ko SH, Lee JM, Park JH, Choi YH
- KMID: 2427170
- Yonsei Med J.
- 2016 Nov;57(6):1494-1499.
- doi: 10.3349/ymj.2016.57.6.1494
PURPOSE: The aim of this study was to investigate whether the peroxisomal proliferator-activated receptor gamma (PPARγ) ligand troglitazone in combination with photodynamic therapy (PDT) enhances the apoptotic response of DLD-1... -
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- Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line
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Han JA, Park SC
- KMID: 1029936
- Exp Mol Med.
- 1999 Jun;31(2):83-88.
Increased expression of Transglutaminases 2 (TGase 2, TGase C) was observed in PC-14 human lung cancer cells in association with doxorubicin resistance and the reduction of the enzyme expression was correlated with... -
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- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
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Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
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- D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells
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Kwon KB, Park EK, Ryu DG, Park BH
- KMID: 1093595
- Exp Mol Med.
- 2002 Mar;34(1):32-37.
Daunorubicin, an anti-cancer drug, is known to induce apoptosis in HL-60 cells in a dose-dependent manner through the activation of caspase-3 (CPP32). Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation... -
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- Suppression of multidrug resistance via inhibition of heat shock factor by quercetin in MDR cells
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Kim SH, Yeo GS, Lim YS, Kang CD, Kim CM, Chung BS
- KMID: 754993
- Exp Mol Med.
- 1998 Jun;30(2):87-92.
MDR1 promoter has been shown to contain heat shock elements (HSE), and it has been reported that FM3A/M and P388/M MDR cells show a constitutively activated heat shock factor (HSF), suggesting that... -
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- Pseudolaric Acid B Inhibits Proliferation, Invasion and Epithelial-to-Mesenchymal Transition in Human Pancreatic Cancer Cell
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Li X, Zhao X, Song W, Tian Z, Yang L, Niu Q, Zhang Q, Xie M, Zhou B, Xu Y, Wu J, Zhang C
- KMID: 2418844
- Yonsei Med J.
- 2018 Jan;59(1):20-27.
- doi: 10.3349/ymj.2018.59.1.20
PURPOSE: This study was aimed to investigate the effect of pseudolaric acid B (PAB) on proliferation, invasion and epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells and to explore the possible... -
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- Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib
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Kang D, Han Z, Oh GH, Joo Y, Choi HJ, Song JJ
- KMID: 2418924
- Yonsei Med J.
- 2017 Sep;58(5):899-909.
- doi: 10.3349/ymj.2017.58.5.899
PURPOSE: Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism... -
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- The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)
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Seo YR, Jung HJ
- KMID: 1103316
- Exp Mol Med.
- 2004 Dec;36(6):505-509.
The p53 tumor suppressor has long been envisaged to preserve genetic stability by the induction of cell cycle checkpoints and apoptosis. More recently, p53 has been implicated to play roles... -
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- IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species
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Paek AR, Kim SH, Kim SS, Kim KT, You HJ
- KMID: 964664
- Exp Mol Med.
- 2010 Oct;42(10):696-702.
- doi: 10.3858/emm.2010.42.10.068
Expression of zinc-finger protein 143 (ZNF143), a human homolog of the Xenopus transcriptional activator protein Staf, is induced by various DNA-damaging agents including etoposide, doxorubicin, and gamma-irradiation. ZNF143 binds to... -
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- Sec13 induces genomic instability in U2OS cells
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Sihn CR, Suh EJ, Lee KH, Kim SH
- KMID: 1056239
- Exp Mol Med.
- 2005 Jun;37(3):255-260.
Sec13p has been known as an endoplasmic reticulum-Golgi transport protein. Recently, it has also been shown to be required for the formation of septation in the fission yeast Schizosaccharomyces pombe.... -
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- Effect of suramin on differentiation of human stomach cancer cell lines
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Choe G, Kim WH, Park JG, Kim YI
- KMID: 1081036
- J Korean Med Sci.
- 1997 Oct;12(5):433-442.
- doi: 10.3346/jkms.1997.12.5.433
This study was designed to demonstrate that differentiation of stomach cancer cells can be modified by microenvironmental change and to look for a method inducing or promoting tumor cell... -
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- The relationship between cisplatin-induced apoptosis and p53, bcl-2 and bax expression in human lung cancer cells
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Han JY, Chung YJ, Park SW, Kim JS, Rhyu MG, Kim HK, Lee KS
- KMID: 759083
- Korean J Intern Med.
- 1999 Jan;14(1):42-52.
OBJECTIVES: Given the roles of bcl-2, bax and p53 in apoptosis, we investigated the effect of their expression on the response to cisplatin in order to understand the... -
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- Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells
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Lee E, Choi MK, Han IO, Lim SJ
- KMID: 1094159
- Exp Mol Med.
- 2006 Jun;38(3):325-331.
SC-560, a strucutral analogue of celecoxib, induces growth inhibition in a wide range of human cancer cells in a cyclooxygenase (COX)-independent manner. Since SC-560 suppresses the growth of cancer cells... -
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- Enhanced induction of Bax gene expression in H460 and H1299 cells with the combined treatment of cisplatin and adenovirus mediated wt-p53 gene transfer
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Choi JH, Ahn KS, Kim JG, Hong YS
- KMID: 927130
- Exp Mol Med.
- 2000 Mar;32(1):23-28.
Cytotoxic effect of either cisplatin or p53 gene transfection of lung cancer cells may be different depending on the p53 status of cells. We investigated cytotoxic effects on the combined... -
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- Change of the Expression of Human Telomerase Reverse Transcriptase mRNA and Human Telomerase RNA after Cisplatin and 5-Fluorouracil Exposure in Head and Neck Squamous Cell Carcinoma Cell Lines
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Lee BJ, Lee BH, Wang SG, Lee JC, Roh HJ, Goh EK, Kim CM, Jun ES
- KMID: 1785792
- J Korean Med Sci.
- 2007 Sep;22(Suppl):S73-S78.
- doi: 10.3346/jkms.2007.22.S.S73
Telomerase activity appears to be associated with cell immortalization and malignant progression. Understanding how telomerase activity is regulated in vivo is important not only for understanding the molecular biology of... -
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- Soluble factor from tumor cells induces heme oxygenase-1 by a nitric oxide-independent mechanism in murine peritoneal macrophages
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Kim SW, Oh HM, Kim BS, Chung HT, Han WC, Kim EC, Kim TH, Seo GS, Lyou JH, Nah YH, Jung JC, Choi SC, Jun CD
- KMID: 1088658
- Exp Mol Med.
- 2003 Feb;35(1):53-59.
Tumor target-derived soluble secretary factor has been known to influence macrophage activation to induce nitric oxide (NO) production. Since heme oxigenase-1 (HO-1) is induced by a variety of conditions associated... -
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