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Induction of Angiogenesis by Malarial Infection through Hypoxia Dependent Manner

Park MK, Ko EJ, Jeon KY, Kim H, Jo JO, Baek KW, Kang YJ, Choi YH, Hong Y, Ock MS, Cha HJ

Malarial infection induces tissue hypoxia in the host through destruction of red blood cells. Tissue hypoxia in malarial infection may increase the activity of HIF1α through an intracellular oxygen-sensing pathway....
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Aberrant Promoter Hypomethylation of Sortilin 1: A Moyamoya Disease Biomarker

Sung HY, Lee JY, Park AK, Moon YJ, Jo I, Park EM, Wang KC, Phi JH, Ahn JH, Kim SK

BACKGROUND AND PURPOSE: The pathogenesis of moyamoya disease (MMD) remains poorly understood, and no reliable molecular biomarkers for MMD have been identified to date. The present study aimed to identify...
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Chronic Cerebral Hypoperfusion Induces Alterations of Matrix Metalloproteinase-9 and Angiopoietin-2 Levels in the Rat Hippocampus

Kim MS, Choi BR, Lee YW, Kim DH, Han YS, Jeon WK, Han JS

Angiogenic factors contribute to cerebral angiogenesis following cerebral hypoperfusion, and understanding these temporal changes is essential to developing effective treatments. The present study examined temporal alterations in angiogenesis-related matrix metalloproteinase-9...
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Comparison of Angiogenic Activities of Three Neuropeptides, Substance P, Secretoneurin, and Neuropeptide Y Using Myocardial Infarction

Lee J, Song M, Kim J, Park Y

BACKGROUND: The interplay between neurogenesis and angiogenesis is crucial during the development mediated by neuro-angiogenic morphogens. In particular, the angiogenic activity of neuropeptides and their role in tissue regeneration have...
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Fabrication of Microchannels and Evaluation of Guided Vascularization in Biomimetic Hydrogels

Lee J, Lee SH, Lee BK, Park SH, Cho YS, Park Y

BACKGROUND: The fabrication of microchannels in hydrogel can facilitate the perfusion of nutrients and oxygen, which leads to guidance cues for vasculogenesis. Microchannel patterning in biomimetic hydrogels is a challenging...
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Clinical assessment after human adipose stem cell transplantation into dogs

Lee SH, Setyawan E, Choi YB, Ra JC, Kang SK, Lee BC, Kim GA

Adipose tissue-derived stem cell (ASCs) are an attractive source of stem cells with therapeutic applicability in various fields for regenerating damaged tissues because of their stemness characteristics. However, little has...
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The effects of proteins released from silk mat layers on macrophages

Kim JW, Jo YY, Kweon HY, Kim DW, Kim SG

BACKGROUND: The objective of this study was to evaluate the changes in gene expression after incubation of cells with proteins released from different silk mat layers. METHODS: A silk cocoon from...
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Epidermal Growth Factor (EGF)-Like Repeats and Discoidin I-Like Domains 3 (EDIL3): A Potential New Therapeutic Tool for the Treatment of Keloid Scars

Ryu YH, Lee YJ, Kim KJ, Lee SJ, Han YN, Rhie JW

In keloids, the mechanism underlying the excessive accumulation of extracellular matrix after injury of the skin is unclear, and there is no effective treatment because of the incomplete understanding of...
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Manipulating the Angiogenesis by Inflammation

Kim MJ, Jin S, Whang YM, Chang IH

There exists a need to develop strategies that promote neovascularization in virtually all tissue engineering and regenerative medicine efforts. While research typically focuses on understanding and exploiting the role of...
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Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?

Macedo F, Ladeira K, Longatto-Filho A, Martins SF

Gastric cancer (GC) has high mortality owing to its aggressive nature. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of GC. The aim of this...
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Systemic Expression of Vascular Endothelial Growth Factor in Patients with Cerebral Cavernous Malformation Treated by Stereotactic Radiosurgery

Park SJ, Park SH

OBJECTIVE: Increased expression of angiogenic factors, such as vascular endothelial growth factor (VEGF), is associated with the pathogenesis of cerebral cavernous malformations (CCMs). The purpose of this study was to...
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Angiogenin for the Diagnosis and Grading of Dry Eye Syndrome

Kim WS, Wee SW, Lee SH, Kim JC

PURPOSE: To investigate the properties of angiogenin (ANG) as a potential tool for the diagnosis and grading of dry eye syndrome (DES) by analyzing tear protein profiles. METHODS: Tear samples were...
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Altered Biological Potential and Radioresponse of Murine Tumors in Different Microenvironments

Lee IJ, Lee EJ, Park H, Kim W, Ha SJ, Shin YK, Seong J

PURPOSE: This study was conducted to evaluate the biological features of murine hepatocarcinoma according to different tumor microenvironmental models and to determine the change in molecular and immunologic responses after...
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Confirmation of HIF-1α Independent Pathway in the Progression of HepG2 Cells by Hypoxic Condition

Lee SW, Chong JU, Min SO, Kim KS

BACKGROUND/AIMS: When hepatocellular carcinoma (HCC) is exposed to hypoxic condition, HIF-1α is activated and results in angiogenesis and increased tumor burden. Although inhibition of HIF-1α may reduce tumor growth, there...
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Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Surrogate Biomarker for Bevacizumab in Colorectal Cancer Liver Metastasis: A Single-Arm, Exploratory Trial

Kim YE, Joo B, Park MS, Shin SJ, Ahn JB, Kim MJ

PURPOSE: The purpose of this study is to investigate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and plasma cytokines and angiogenic factors (CAFs) as pharmacodynamic and prognostic biomarkers of bevacizumab monotherapy...
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Maternal Preeclampsia and Bronchopulmonary Dysplasia

Kim DH

Preeclampsia is one of the most common complications of pregnancy that is prevalent worldwide, resulting in substantial maternal and neonatal morbidity and mortality. Although the cause remains unclear, preeclampsia may...
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Expression of angiogenic factors in cryopreserved mouse ovaries after heterotopic autotransplantation

Choi WJ, Seok JS, Choi IY, Park JK, Shin JK, Lee SA, Paik WY, Lee JH

OBJECTIVE: Revascularization is critical for successful ovarian tissue transplantation. Vascular endothelial growth factor (VEGF) and angiopoietin-2 (angpt-2) are the principal mediators of neovascularization. This study was designed to assess VEGF...
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COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway

Moon HE, Byun K, Park HW, Kim JH, Hur J, Park JS, Jun JK, Kim HS, Paek SL, Kim IK, Hwang JH, Kim JW, Kim DG, Sung YC, Koh GY, Song CW, Lee B, Paek SH

Successful recovery from brain ischemia is limited due to poor vascularization surrounding the ischemic zone. Cell therapy with strong angiogenic factors could be an effective strategy to rescue the ischemic...
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Multi-facets of Corticotropin-releasing Factor in Modulating Inflammation and Angiogenesis

Im E

  • KMID: 2381229
  • J Neurogastroenterol Motil.
  • 2015 Jan;21(1):25-32.
  • doi: 10.5056/jnm14076
The family of corticotropin-releasing factor (CRF) composed of 4 ligands including CRF, urocortin (Ucn) 1, Ucn2, and Ucn3 is expressed both in the central nervous system and the periphery including...
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Genetics and Biomarkers of Moyamoya Disease: Significance of RNF213 as a Susceptibility Gene

Fujimura M, Sonobe S, Nishijima , Niizuma K, Sakata H, Kure S, Tominaga T

  • KMID: 2223711
  • J Stroke.
  • 2014 May;16(2):65-72.
Moyamoya disease is characterized by a progressive stenosis at the terminal portion of the internal carotid artery and an abnormal vascular network at the base of the brain. Although its...
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