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Bone Biology and Anabolic Therapies for Bone: Current Status and Future Prospects

Martin TJ

  • KMID: 2391949
  • J Bone Metab.
  • 2014 Feb;21(1):8-20.
Bone is continuously remodelled at many sites asynchronously throughout the skeleton, with bone formation and resorption balanced at these sites to retain bone structure. Negative balance resulting in bone loss...
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Emerging Anabolic Therapies for Osteoporosis

Choi HJ

Osteoporosis is defined as low bone mineral density (BMD) associated with fragility fractures. It is characterized by unbalanced bone remodeling activity leading to bone loss and eventually fractures. Osteoporosis-related fractures...
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Spontaneous Corpus Cavernosum Abscess in a Healthy Man Using Long-Term Androgenic Anabolic Steroids

Tuzel E

Abscess formation of the corpus cavernosum is very rare. Here, we report a case of long-term anabolic androgenic steroid (AAS) abuse that is suspected to have facilitated the development of...
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Nonsurgical Treatment Strategies after Osteoporotic Hip Fractures

Min BW, Song KS, Bae KC, Cho CH, Son ES, Lee KJ

Osteoporosis is a metabolic disease that is increasing in prevalence as people live longer. Because the orthopedic surgeon is frequently the first and often the only physician to manage patients...
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Stevens-Johnson syndrome and abuse of anabolic steroids

Cocca S, Viviano M

Stevens-Johnson syndrome (SJS) is characterized by mucocutaneous tenderness and typical hemorrhagic erosions, erythema and epidermal detachment presenting as blisters and areas of denuded skin. SJS is often observed after drug...
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Recent Advances in the Drug Therapy of Osteoporosis

Lee HW

  • KMID: 2320272
  • Yeungnam Univ J Med.
  • 1999 Dec;16(2):155-168.
Osteoporosis is one of the most important public health problems facing the aging population. Drug therapy for osteoporosis can be divided operationally into two main categories: drugs that inhibit bone...
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Pharmacologic treatment of osteoporosis

Min YK

The objectives of this article are to review current pharmacologic approaches for the treatment of osteoporosis in Korea. Calcium and vitamin D supplementation are necessary for osteoporotic patients with inadequate...
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Pharmacologic Therapy for Cancer Anorexia-Cachexia Syndrome

Yoon S, Kim H

Cancer-related anorexia-cachexia syndrome (CACS) is a hypercatabolic state, characterized by reduced appetite and weight loss due to ongoing loss of skeletal muscle mass and adipose tissue. CACS occurs mainly in...
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Analgesic Effects of Antiosteoporotic Drugs

Ahn DK, Shin WS, Kim GW

STUDY DESIGN: Literature review. OBJECTIVES: To propose possible mechanisms of osteoporotic back pain and its management with antiosteoporotic drugs. SUMMARY OF LITERATURE REVIEW: No general conclusion has yet been reached regarding whether...
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Strategies of Spinal Fusion on Osteoporotic Spine

Park SB, Chung CK

The prevalence of osteoporosis has been increasing globally. Recently surgical indications for elderly patients with osteoporosis have been increasing. However, only few strategies are available for osteoporotic patients who need...
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The Effects of Simvastatin on Bone Healing in Mandible Fractured Rats

Jeong JO, Kwon YS, Kim SK, Lee KC

  • KMID: 2322197
  • J Korean Soc Plast Reconstr Surg.
  • 2009 Sep;36(5):525-530.
PURPOSE: The hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) are widely used in the treatment of dyslipidemia for lowering of cholesterol level. And the studies in simvastatins have shown to enhance...
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Diabetes and Osteoporosis

Oh KW

Increased life expectancy and increased obesity have contributed to an increasing incidence of osteoporosis and diabetes mellitus. Recent meta-analyses and cohort studies confirm that diabetes is associated with a higher...
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Identification and Validation of the Relationship of the Anabolic Effect of Parathyroid Hormone with the Wnt/beta-catenin Canonical Pathway

Kim SH, An JJ, Rhee Y, Lim SK

BACKGROUND: It has been well established that daily injections of low dose parathyroid hormone (PTH) increase bone mass in animals and humans. However, the precise mechanisms by which PTH exerts...
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Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model

Kwon YJ

This study was done to evaluate whether injections of resveratrol, a natural compound found in the skin of grapes, had anabolic effects on degenerated intervertebral discs in a rabbit model....
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Pleiotrophin (PTN) expression in osteoblastic cells

Kim B, Rim J, Kwon J, Jang H, Lee E, Jun S, Kim Y

  • KMID: 2005054
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2007 Nov;29(6):494-498.
Pleiotrophin or osteoblast-specific factor 1(OSF-1) is a growth-associated protein present in bone matrix. This study was designed to study pleiotrophin expression in osteoblastic cells. Pleiotrophin was expressed by osteoblast-like cell...
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Regulation of Osteoblast Metabolism by Wnt Signaling

Moorer MC, Riddle RC

Wnt/β-catenin signaling plays a critical role in the achievement of peak bone mass, affecting the commitment of mesenchymal progenitors to the osteoblast lineage and the anabolic capacity of osteoblasts depositing...
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Changes in Serum Concentrations of Insulin-like Growth Factor-1 (IGF-1) during Different Methods of General Anesthesia

Kim JH, Baik HJ

BACKGROUND: IGFs (insulin-like growth factors) exert acute anabolic effects on protein and carbohydrate metabolism, and have a long-term impact on cell proliferation, differentiation, and apoptosis. The purpose of this study...
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The Effect of Anabolic Steroid on Body Composition and Protein Metabolism in Malnourished CAPD Patients

Lee SW, Kwon KH, Kim GA, Shin HJ, Bae SK, Song KS, Kim MJ, Oh MW, Kim JJ

  • KMID: 2254753
  • Korean J Nephrol.
  • 1997 Dec;16(4):724-729.
To evaluate the effect of anabolic steroid(AS) on body composition and protein metabolism in malnourished CAPD patients, 7 CAPD patients who were proved to be malnourished by subjective global assessment...
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Anabolic Effects of Recombinant Human Parathyroid Hormone (1-84) on Bone Histomorphometry in Overiectomized Rats

Won YJ, Park DH, Nam JH, Yook JI, Kim J, Kim KR, Lee HC, Huh KB, Lim SK

  • KMID: 2331138
  • J Korean Soc Endocrinol.
  • 1999 Mar;14(1):81-90.
To evaluate the anabolic effects of human recombinant parathyroid hormone [hrPTH(1-84)], we examined effect of low-dose and high-dose of [hrPTH(1-84)] and estradiol on bone histomorphometry in ovariectomized rats. Sixty Sprague-Dawley...
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Anabolic Steroid(AS) on Nutritional Parameters in Malnourished Continuous Ambulatory Peritoneal Dialysis(CAPD) Patients

Kim MJ, Kwon KH, Lee SW

  • KMID: 2254751
  • Korean J Nephrol.
  • 1997 Dec;16(4):718-723.
Protein-energy malnutrition is frequently observed in CAPD patients and is closely correlated with morbidity and mortality. We investigated the effects of AS on nutritional parameters in malnourished CAPD patients. Eleven...
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