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Characterizing affinity epitopes between prion protein and beta-amyloid using an epitope mapping immunoassay

Kang M, Kim SY, An SS, Ju YR

  • KMID: 2154253
  • Exp Mol Med.
  • 2013 Aug;45(8):e34.
Cellular prion protein, a membrane protein, is expressed in all mammals. Prion protein is also found in human blood as an anchorless protein, and this protein form is one of...
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Independent and Interactive Influences of the APOE Genotype and Beta-Amyloid Burden on Cognitive Function in Mild Cognitive Impairment

Seo EH, Kim SH, Park SH, Kang SH, Choo IH, Alzheimer's Disease Neuroimaging Initiative

This study aimed to investigate the independent and interactive influences of apolipoprotein E (APOE) epsilon4 and beta-amyloid (Abeta) on multiple cognitive domains in a large group of cognitively normal (CN)...
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Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Abeta pathology and improves cognitive function

Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL

  • KMID: 1402318
  • Exp Mol Med.
  • 2012 Dec;44(12):740-748.
The plant viral protease, NIa, has a strict substrate specificity for the consensus sequence of Val-Xaa-His-Gln, with a scissoring property after Gln. We recently reported that NIa efficiently cleaved the...
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