- Enhanced Expression of Aldosterone Synthase and Adrenomedullin in Left and Right Ventricular Hypertrophy in Rats
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Lee JU, Lee S, Kim S, Lee WJ
- KMID: 1615003
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):121-126.
The pathophysiological implications of aldosterone and adrenomedullin in the cardiac ventricular hypertrophy were examined. Male Sprague-Dawley rats were treated with deoxycorticosterone acetate (DOCA)-salt and monocrotaline (MCT) to selectively elicit left... -
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- Aldosterone Synthase Gene (CYP11B2) Polymorphism in Korean End-Stage Renal Disease Patients on Hemodialysis
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Lee JE, Bae SY, Kim JY, Pyo HJ, Western Dialysis Physician Association (WDPA), Kwon YJ
- KMID: 2052321
- Electrolyte Blood Press.
- 2009 Dec;7(2):67-72.
- doi: 10.5049/EBP.2009.7.2.67
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism has been reported to be associated with serum aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. The aim of... -
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- The Effects of an Aldosterone Synthase (CYP11B2) Gene Polymorphism on the Risk of Myocardial Infarction
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Ryu SK, Park HY, Im EK, Yoon YW, Jang Y, Yoon YW, Shim WH, Cho SY
- KMID: 1938915
- Korean Circ J.
- 2001 Dec;31(12):1261-1266.
- doi: 10.4070/kcj.2001.31.12.1261
BACKGROUND AND OBJECTIVES: Several polymorphisms of the renin-angiotensin-aldosterone system have been found to have pleiotropic effects on cardiovascular diseases. Polymorphism of the aldosterone synthase gene (CYP11B2), which may influence plasma... -
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- Upregulation of Renin-angiotensin, Endothelin and C-type Natriuretic Peptide in Rat Glomerulus with Bilateral Ureteral Obstruction
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Bae EH, Kim SW
- KMID: 1587476
- Korean J Physiol Pharmacol.
- 2006 Dec;10(6):343-347.
The present study was designed to investigate the effects renin-angiotensin-aldosterone system (RAAS), endothelin (ET) and local natriuretic peptide (NP) system for glomerulopathy induced in the experimental bilateral ureteral obstructive rats.... -
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- Decreased expression of Na,K-ATPase in the kidneys of rats with two-kidney, one-clip hypertension
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Ma SK, Oh YW, Kim IJ, Bae EH, Lee JU, Kim SW
- KMID: 2259162
- Korean J Med.
- 2010 Apr;78(4):477-484.
BACKGROUND/AIMS: This study investigated the role of Na,K-ATPase, the local renin-angiotensin-aldosterone system (RAAS), and atrial natriuretic peptide (ANP) system in the pathogenesis of renal tubular dysfunction and hypertension in rats... -
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- Genetic Analyses of the Chimeric CYP11B1/CYP11B2 Gene in a Korean Family with Glucocorticoid-Remediable Aldosteronism
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Lee IS, Kim SY, Jang HW, Kim MK, Lee JH, Lee YH, Jo YS
- KMID: 1785922
- J Korean Med Sci.
- 2010 Sep;25(9):1379-1383.
- doi: 10.3346/jkms.2010.25.9.1379
Glucocorticoid-remediable aldosteronism (GRA) is an autosomal-dominant inheritable form of hyperaldosteronism with early onset hypertension. GRA is caused by unequal crossing-over of the steroid 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes.... -
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- Interaction of Pituitary Adenylate Cyclase-Activating Polypeptide and Angiotensin II on Aldosterone Production in Human Adrenocortical H295R Cells
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Kim SY, Kim SW, Cho YM, Park DJ, Shin CS, Park KS, Cho BY, Lee HK
- KMID: 2200306
- J Korean Soc Endocrinol.
- 2003 Jun;18(3):272-282.
BACKGROUND: Evidence is accumulating that aldosterone secretion can be regulated in a paracrine and/or an autocrine manner by several neuropeptides locally released within the adrenal gland. Among neuropeptides, pituitary adenylate... -
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- Increased Expression of Endothelin-1 and CYP11B2 in Gentamicin-Induced Nephropathy in Rat Kidney
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Bae EH, Kim IJ, Oh YW, Bae WK, Park JW, Ma SK, Kim NH, Choi KC, Lee JU, Kim SH, Kim SW
- KMID: 2253701
- Korean J Nephrol.
- 2007 Nov;26(6):660-668.
PURPOSE: An altered activity of vasoactive hormones as well as aldosterone synthase (CYP11B2) in the kidney may involve the pathogenesis of gentamicin-induced nephropathy. The present study was designed to investigate... -
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- Renin-Angiotensin-Aldosterone System (RAAS) Gene Polymorphism as a Risk Factor of Coronary In-Stent Restenosis
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Ryu SK, Cho EY, Park HY, Im EK, Jang Y, Shin GJ, Shim WH, Cho SY
- KMID: 1122005
- Yonsei Med J.
- 2002 Aug;43(4):461-472.
- doi: 10.3349/ymj.2002.43.4.461
Intimal proliferation is a main cause of in-stent restenosis. Over-excretion of angiotensin I converting enzyme (ACE) and aldosterone is reported to stimulate intimal hyperplasia and the genetic effect of these... -
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