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Evolution of Asthma Concept and Effect of Current Asthma Management Guidelines

Makino S, Sagara H

Concept of asthma has changed from symptom-complex or airway hypersensitivity to airway inflammation and airway remodeling. Based on this concept asthma management guidelines (JGL) has been developed in Japan. Death...
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Role of TGF beta1 in airway remodeling

Lee YC

  • KMID: 2285876
  • J Asthma Allergy Clin Immunol.
  • 2002 Sep;22(3):529-531.
No abstract available.
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Airway epithelial cells in airway inflammation and remodeling in asthma

Kim SH

Airway epithelial cells are the front-line barrier to outer world, and abnormal response to environmental agents can cause asthma. Large numbers of recent studies support the evidence that airway epithelial...
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Airway Remodeling in Asthma

  • KMID: 2299690
  • Korean J Asthma Allergy Clin Immunol.
  • 2005 Jun;25(2):90-94.
No abstract available.
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Mechanical Stimuli to Airway Remodeling in Asthma

  • KMID: 2299473
  • Korean J Asthma Allergy Clin Immunol.
  • 2012 Mar;32(1):1-7.
Airway remodeling implies structural changes in the airways of patients with asthma. These changes are associated with poor long-term clinical outcomes and are attributed to chronic airway inflammation. However, some...
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Airway Remodeling

Kim KH

No Abstract available.
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Effects of CpG-oligodeoxynucleotides in Chronic Inflammation and Remodeling of Airway in a Murine Model of Bronchial Asthma

Song SH, Kim CH, Han DH, Kim SJ, Moon HS, Song JS, Park SH

BACKGROUND: Airway remodeling of the asthmatic airway, the result of persistent inflammation in the bronchial wall, is associated with irreversible airway obstruction and the severity of asthma. Previous reports had...
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Bronchial Structural Changes in Childhood Asthma

Shin YS, Pyun BY

  • KMID: 2314177
  • Pediatr Allergy Respir Dis.
  • 1998 Sep;8(2):190-197.
PURPOSE: While asthma has been considered to be a completely reversible obstructive airway disease, many asthmatics have evidences of residual airway obstruction. Therefore, with the recent attention to the cells...
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Angiogenic Factors Play a Significant Role in Nasal Airway Remodeling in Allergic Rhinitis

Dhong HJ

No abstract available.
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Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma

Hur GY, Broide DH

Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics. Airway remodeling is characterized...
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Update in asthma management

Lee HR

Asthma is a chronic inflammation of the airway associated with increased bronchial hyperresponsiveness that leads to recurrent episodes of cough, wheezing, breathless, chest tightness. According the recent studies, repeated airway...
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Inhibitory Effects of Resveratrol on Airway Remodeling by Transforming Growth Factor-β/Smad Signaling Pathway in Chronic Asthma Model

Lee HY, Kim IK, Yoon HK, Kwon SS, Rhee CK, Lee SY

PURPOSE: Asthma is a chronic airway disease characterized by airway remodeling, leading to a progressive decline in lung function. Therapeutic agents that attenuate airway remodeling can complement the limited effects...
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Airway remodelling in asthma: role for mechanical forces

Manuyakorn W

Asthma is a chronic airway inflammatory disease with functional and structural changes, leading to bronchial hyperresponsiveness and airflow obstruction. Airway structural changes or airway remodelling consist of epithelial injury, goblet...
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TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model

Choi JY, Lee HY, Hur J, Kim KH, Kang JY, Rhee CK, Lee SY

PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1...
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The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma

Kwak HJ, Park DW, Seo JY, Moon JY, Kim TH, Sohn JW, Shin DH, Yoon HJ, Park SS, Kim SH

Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is...
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bFGF & FGFR Expression in Chronic Airway Remodeling of Asthma

Yum HY

  • KMID: 2314418
  • Pediatr Allergy Respir Dis.
  • 2006 Dec;16(4):267-273.
A number of structural changes occur in the airway wall in asthma. The most characteristic is thickening of the subepithelial lamina reticularis which is observed in bronchial tissue even in...
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Relationship Between Vascularity and Other Remodeling Parameters in Asthmatic Airway

Kim SJ, Lee SY, Kim MS, Lo DK, Kwon SS, Kim YK, Kim KH, Moon HS, Song JS, Park SH

BACKGROUND: The pathological features in asthmatic airway remodeling are diverse. The aim of this study was to examine the degree of airway vascularity in relation to the other remodeling parameters...
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Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma

Kang JY, Kim IK, Hur J, Kim SC, Lee SY, Kwon SS, Kim YK

BACKGROUND: Efficacy and safety of tiotropium bromide, a muscarinic receptor antagonist, in treatment of asthma have been reported. However, its effect on airway remodeling in chronic asthma of the elderly...
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Role of Matrix Metalloproteinase-9 in Asthma

Lim DH

  • KMID: 1876610
  • Pediatr Allergy Respir Dis.
  • 2006 Mar;16(1):12-22.
Variable airway obstruction, increased bronchial hyperresponsiveness, allergic inflammatory reaction and airway remodeling are main characteristics of asthma. Matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases(TIMPs) do play important...
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Siglec-8: Novel Therapeutic Approach for Eosinophilic Inflammation and Airway Remodeling

Song DJ

  • KMID: 2314874
  • Pediatr Allergy Respir Dis.
  • 2008 Jun;18(2):114-120.
Eosinophil is an important therapeutic target in the management of asthma due to their important role in airway inflammation, induction of airway hyperresponsiveness and their recently described role in airway...
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