- The Interplay between Host Immunity and Respiratory Viral Infection in Asthma Exacerbation
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Hossain FM, Choi JY, Uyangaa E, Park SO, Eo SK
- KMID: 2461195
- Immune Netw.
- 2019 Oct;19(5):e31.
- doi: 10.4110/in.2019.19.e31
Asthma is one of the most common and chronic diseases characterized by multidimensional immune responses along with poor prognosis and severity. The heterogeneous nature of asthma may be attributed to... -
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- Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
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Hur GY, Broide DH
- KMID: 2452752
- Allergy Asthma Immunol Res.
- 2019 Sep;11(5):604-621.
- doi: 10.4168/aair.2019.11.5.604
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics. Airway remodeling is characterized... -
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- Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice
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Huang Q, Han L, Lv R, Ling L
- KMID: 2450492
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):251-261.
- doi: 10.4196/kjpp.2019.23.4.251
Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cells-derived cytokines are critically associated with asthma pathogenesis. Janus kinase-signal... -
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- The Role of Autophagy in Eosinophilic Airway Inflammation
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Lee J, Kim HS
- KMID: 2438913
- Immune Netw.
- 2019 Feb;19(1):e5.
- doi: 10.4110/in.2019.19.e5
Autophagy is a homeostatic mechanism that discards not only invading pathogens but also damaged organelles and denatured proteins via lysosomal degradation. Increasing evidence suggests a role for autophagy in inflammatory... -
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- Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma
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Kang JY, Kim IK, Hur J, Kim SC, Lee SY, Kwon SS, Kim YK
- KMID: 2441732
- Tuberc Respir Dis.
- 2019 Jan;82(1):71-80.
- doi: 10.4046/trd.2018.0049
BACKGROUND: Efficacy and safety of tiotropium bromide, a muscarinic receptor antagonist, in treatment of asthma have been reported. However, its effect on airway remodeling in chronic asthma of the elderly... -
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- Influence of rutin on the effects of neonatal cigarette smoke exposure-induced exacerbated MMP-9 expression, Th17 cytokines and NF-κB/iNOS-mediated inflammatory responses in asthmatic mice model
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Liu LL, Zhang Y, Zhang XF, Li FH
- KMID: 2418998
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):481-491.
- doi: 10.4196/kjpp.2018.22.5.481
Allergic asthma is one of the most enduring diseases of the airway. The T-helper cells and regulatory T-cells are critically involved in inflammatory responses, mucus hypersecretion, airway remodelling and in... -
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- TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model
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Choi JY, Lee HY, Hur J, Kim KH, Kang JY, Rhee CK, Lee SY
- KMID: 2409056
- Allergy Asthma Immunol Res.
- 2018 May;10(3):216-224.
- doi: 10.4168/aair.2018.10.3.216
PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1... -
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- Quantitative CT Imaging in Chronic Obstructive Pulmonary Disease: Review of Current Status and Future Challenges
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Cho YH, Seo JB, Lee SM, Lee SM, Choe J, Lee D, Kim N
- KMID: 2399300
- J Korean Soc Radiol.
- 2018 Jan;78(1):1-12.
- doi: 10.3348/jksr.2018.78.1.1
Chronic Obstructive Pulmonary Disease (COPD) is a complex heterogeneous condition with various clinical and pathologic features. In recent years, technical advances in quantitative CT imaging have generated considerable interest because... -
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- Immune Cell Responses and Mucosal Barrier Disruptions in Chronic Rhinosinusitis
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Khalmuratova R, Park JW, Shin HW
- KMID: 2368977
- Immune Netw.
- 2017 Feb;17(1):60-67.
- doi: 10.4110/in.2017.17.1.60
Chronic rhinosinusitis (CRS) is one of the most common presentations of upper airway illness and severely affects patient quality of life. Its frequency is not surprising given levels of environmental... -
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- Inhibitory Effects of Resveratrol on Airway Remodeling by Transforming Growth Factor-β/Smad Signaling Pathway in Chronic Asthma Model
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Lee HY, Kim IK, Yoon HK, Kwon SS, Rhee CK, Lee SY
- KMID: 2355891
- Allergy Asthma Immunol Res.
- 2017 Jan;9(1):25-34.
- doi: 10.4168/aair.2017.9.1.25
PURPOSE: Asthma is a chronic airway disease characterized by airway remodeling, leading to a progressive decline in lung function. Therapeutic agents that attenuate airway remodeling can complement the limited effects... -
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- Different anti-remodeling effect of nilotinib and fluticasone in a chronic asthma model
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Kang HS, Rhee CK, Lee HY, Yoon HK, Kwon SS, Lee SY
- KMID: 2382865
- Korean J Intern Med.
- 2016 Nov;31(6):1150-1158.
- doi: 10.3904/kjim.2015.002
BACKGROUND/AIMS: Inhaled corticosteroids are the most effective treatment currently available for asthma, but their beneficial effect against airway remodeling is limited. The tyrosine kinase inhibitor nilotinib has inhibitory activity against... -
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- Adenovirus-mediated Foxp3 expression in lung epithelial cells reduces airway inflammation in ovalbumin and cockroach-induced asthma model
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Park S, Chung HS, Shin D, Jung KH, Lee H, Moon J, Bae H
- KMID: 2361546
- Exp Mol Med.
- 2016 Sep;48(9):e259.
- doi: 10.1038/emm.2016.83
Foxp3 is a master regulator of CD4âºCD25⺠regulatory T-cell (Treg) function and is also a suppressor of SKP2 and HER2/ErbB2. There are an increasing number of reports describing the functions... -
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- Long-Term Effects of Diesel Exhaust Particles on Airway Inflammation and Remodeling in a Mouse Model
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Kim BG, Lee PH, Lee SH, Kim YE, Shin MY, Kang Y, Bae SH, Kim MJ, Rhim T, Park CS, Jang AS
- KMID: 2391045
- Allergy Asthma Immunol Res.
- 2016 May;8(3):246-256.
- doi: 10.4168/aair.2016.8.3.246
PURPOSE: Diesel exhaust particles (DEPs) can induce and trigger airway hyperresponsiveness (AHR) and inflammation. The aim of this study was to investigate the effect of long-term DEP exposure on AHR,... -
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- CT Quantification of Central Airway in Tracheobronchomalacia
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Im WH, Jin GY, Han YM, Kim EY
- KMID: 2164825
- J Korean Soc Radiol.
- 2016 May;74(5):299-307.
- doi: 10.3348/jksr.2016.74.5.299
PURPOSE: To know which factors help to diagnose tracheobronchomalacia (TBM) using CT quantification of central airway. MATERIALS AND METHODS: From April 2013 to July 2014, 19 patients (68.0 ± 15.0 years;... -
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- Airway epithelial cells in airway inflammation and remodeling in asthma
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Kim SH
- KMID: 2361279
- Allergy Asthma Respir Dis.
- 2016 Mar;4(2):82-90.
- doi: 10.4168/aard.2016.4.2.82
Airway epithelial cells are the front-line barrier to outer world, and abnormal response to environmental agents can cause asthma. Large numbers of recent studies support the evidence that airway epithelial... -
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- Administration of Pigment Epithelium-Derived Factor Inhibits Airway Inflammation and Remodeling in Chronic OVA-Induced Mice via VEGF Suppression
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Zha W, Su M, Huang M, Cai J, Du Q
- KMID: 2165933
- Allergy Asthma Immunol Res.
- 2016 Mar;8(2):161-169.
- doi: 10.4168/aair.2016.8.2.161
PURPOSE: Pigment epithelium-derived factor (PEDF) is a recently discovered antiangiogenesis protein. PEDF possesses powerful anti-inflammatory, antioxidative, antiangiogenic, and antifibrosis properties. It has been reported that PEDF can regulate vascular endothelial... -
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- Effect of intranasal rosiglitazone on airway inflammation and remodeling in a murine model of chronic asthma
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Lee HY, Rhee CK, Kang JY, Park CK, Lee SY, Kwon SS, Kim YK, Yoon HK
- KMID: 2373777
- Korean J Intern Med.
- 2016 Jan;31(1):89-97.
- doi: 10.3904/kjim.2016.31.1.89
BACKGROUND/AIMS: Asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Peroxisome proliferator-activated receptors have been reported to regulate inflammatory responses in many cells. In this study, we examined the effects... -
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- The Wnt/beta-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
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Kwak HJ, Park DW, Seo JY, Moon JY, Kim TH, Sohn JW, Shin DH, Yoon HJ, Park SS, Kim SH
- KMID: 2359885
- Exp Mol Med.
- 2015 Dec;47(12):e198.
- doi: 10.1038/emm.2015.91
Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is... -
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- Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat
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Li X, Shen Y, Lu Y, Yang J
- KMID: 2285584
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):401-411.
- doi: 10.4196/kjpp.2015.19.5.401
Aldose reductase (AR) is known to play a crucial role in the mediation of diabetic and cardiovascular complications. Recently, several studies have demonstrated that allergen-induced airway remodeling and ovalbumin-induced asthma... -
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- The Therapeutic Effects of Optimal Dose of Mesenchymal Stem Cells in a Murine Model of an Elastase Induced-Emphysema
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Kim YS, Kim JY, Huh JW, Lee SW, Choi SJ, Oh YM
- KMID: 2320649
- Tuberc Respir Dis.
- 2015 Jul;78(3):239-245.
- doi: 10.4046/trd.2015.78.3.239
BACKGROUND: Chronic obstructive pulmonary disease is characterized by emphysema, chronic bronchitis, and small airway remodeling. The alveolar destruction associated with emphysema cannot be repaired by current clinical practices. Stem cell... -
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