- Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells
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Kwon D, Choi IH
- KMID: 1779506
- Yonsei Med J.
- 2006 Aug;47(4):551-557.
- doi: 10.3349/ymj.2006.47.4.551
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing... -
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- Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4
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Lee KH, Choi EY, Hyun MS, Kim JR
- KMID: 755666
- Exp Mol Med.
- 2004 Feb;36(1):57-64.
Clinical studies have shown that tumor hypoxia is associated with invasive growth and metastasis and may be an important prognostic factor adversely influencing survival in patients with tumors. To investigate... -
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- Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27
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Seo YJ, Jeon MH, Lee JH, Lee YJ, Youn HJ, Ko JH, Lee JH
- KMID: 1116208
- Exp Mol Med.
- 2005 Dec;37(6):624-630.
Bis (Bag-3, CAIR), a Bcl-2-interacting protein, promotes the anti-apoptotic activity of Bcl-2 and increased levels of Bis have been observed in several disease models. The involvement of Bcl-2 and some... -
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- Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells
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Choi YJ, Kim SY, Oh JM, Juhnn YS
- KMID: 1119325
- Exp Mol Med.
- 2009 Aug;41(8):592-600.
- doi: 10.3858/emm.2009.41.8.065
Stimulatory heterotrimeric GTP-binding proteins (Gs protein) stimulate cAMP generation in response to various signals, and modulate various cellular phenomena such as proliferation and apoptosis. This study aimed to investigate the... -
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- Representational difference analysis of cDNA identifies novel genes expressed following preconditioning of the heart
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Fauchon MA, Pell TJ, Baxter GF, Yellon DM, Latchman D, Hubank MF, Mayn LV
- KMID: 1093466
- Exp Mol Med.
- 2005 Aug;37(4):311-322.
Preconditioning of the myocardium rapidly induces a number of transcription factors, which are likely to be responsible for a cascade of transcriptional changes underlying the development of delayed adaptation. Identifying... -
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- Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the expression of beta-catenin, leading to a rapid proliferation of pancreatic cells
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Cho IR, Koh SS, Min HJ, Kim SJ, Lee Y, Park EH, Ratakorn S, Jhun BH, Oh S, Johnston R, Chung YH
- KMID: 1097265
- Exp Mol Med.
- 2011 Feb;43(2):82-90.
- doi: 10.3858/emm.2011.43.2.010
It is not yet understood how the enhanced expression of pancreatic adenocarcinoma up-regulated factor (PAUF; a novel oncogene identified in our recent studies), contributes to the oncogenesis of pancreatic cells.... -
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- Neuronal activation increases the density of eukaryotic translation initiation factor 4E mRNA clusters in dendrites of cultured hippocampal neurons
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Moon IS, Cho SJ, Seog DH, Walikonis
- KMID: 1119326
- Exp Mol Med.
- 2009 Aug;41(8):601-610.
- doi: 10.3858/emm.2009.41.8.066
Activity-dependent dendritic translation in CNS neurons is important for the synapse-specific provision of proteins that may be necessary for strengthening of synaptic connections. A major rate-limiting factor during protein synthesis... -
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- The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
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Park MH, Choi KY, Min DS
- KMID: 2359887
- Exp Mol Med.
- 2015 Dec;47(12):e200.
- doi: 10.1038/emm.2015.101
Endocytosis is differentially regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) and phospholipase D (PLD). However, the relationship between HIF-1alpha and PLD in endocytosis is unknown. HIF-1alpha is degraded through the prolyl hydroxylase... -
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- Upregulation of Glutamate Receptors in Rat Cerebral Cortex with Neuronal Migration Disorders
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Lee MC, Shim JJ, Kim JH, Kim MK, Woo YJ, Chung WK, Suh JJ, Nam SC, Lee JS, Kim YS, Kim JH, Kim HI
- KMID: 1786822
- J Korean Med Sci.
- 2004 Jun;19(3):419-425.
- doi: 10.3346/jkms.2004.19.3.419
Neuronal migration disorders (NMDs) constitute the main pathologic substrate of medically intractable epilepsy in human. This study is designed to investigate the changes in expression of glutamate receptor subtypes on... -
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- Upregulation of CD47 in Regulatory T Cells in Atopic Dermatitis
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Lee N, Shin JU, Jin S, Yun KN, Kim JY, Park CO, Kim SH, Noh JY, Lee KH
- KMID: 2427162
- Yonsei Med J.
- 2016 Nov;57(6):1435-1445.
- doi: 10.3349/ymj.2016.57.6.1435
PURPOSE: Regulatory T (Treg) cells are key modulators in the immune system. Recent studies have shown that atopic dermatitis (AD) patients have higher numbers of Treg cells; however, little is... -
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- MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis
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Lee DG, Woo JW, Kwok SK, Cho ML, Park SH
- KMID: 2154239
- Exp Mol Med.
- 2013 Apr;45(4):e20.
Myeloid-related protein (MRP)8/MRP14 is an endogenous Toll-like receptor 4 (TLR4) ligand and is abundant in synovial fluid (SF) of rheumatoid arthritis (RA) patients. Belonging to damage-associated molecular patterns, it amplifies... -
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- Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis
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Kim MD, Kim SS, Cha HY, Jang SH, Chang DY, Kim W, Suh-Kim H, Lee JH
- KMID: 2155375
- Exp Mol Med.
- 2014 Aug;46(8):e110.
- doi: 10.1038/emm.2014.49
Bone marrow-derived mesenchymal stromal cells (MSCs) have been reported to be beneficial for the treatment of liver fibrosis. Here, we investigated the use of genetically engineered MSCs that overexpress hepatocyte... -
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