- Is a Microsatellite Instability Still Useful for Tailored Treatment in Stage II and III Colon Cancer?
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Kim NK
- KMID: 2134003
- Ann Coloproctol.
- 2014 Feb;30(1):5-6.
- doi: 10.3393/ac.2014.30.1.5
No abstract available. -
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- Impact of Microsatellite Instability in Signet-Ring Cell and Mucinous Components in Patients With Colorectal Carcinoma
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Kim IY
- KMID: 2408766
- Ann Coloproctol.
- 2016 Apr;32(2):45-46.
- doi: 10.3393/ac.2016.32.2.45
No abstract available. -
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- Genomic Instability in Colorectal Cancer; from Bench to Bed
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Lee KY
- KMID: 2334430
- J Korean Soc Coloproctol.
- 2009 Apr;25(2):129-138.
Colorectal cancer is a disease developed by the accumulation of genomic alteration. Two genomic instability pathways, chromosomal instability pathway and microsatellite instability pathway, are known as the main pathways of... -
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- Mutation of the Chk1 Gene in Gastric Cancers with Microsatellite Instability
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Lee JH, Cho YG, Song JW, Park CH, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS
- KMID: 2372791
- J Korean Gastric Cancer Assoc.
- 2005 Dec;5(4):260-265.
PURPOSE: The protein kinase Chk1 is required for cell cycle arrest in response to DNA damage and is shown to play an important role in the G2/M checkpoint. The aim... -
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- The Role of Microsatellite Instability in Early Gastric Cancer
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Kim JJ
- KMID: 1112582
- Korean J Gastroenterol.
- 2008 Mar;51(3):209-211.
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- A Frameshift Mutation of the Pro-Apoptotic VDAC1 Gene in Cancers with Microsatellite Instability
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Yoo NJ, Park SW, Lee SH
- KMID: 2284251
- Gut Liver.
- 2011 Dec;5(4):548-549.
No abstract available. -
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- Mutational Analysis of ASPP1 and ASPP2 Genes, a p53-related Gene, in Gastric and Cololorectal Cancers with Microsatellite Instability
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Park SW, An CH, Kim SS, Yoo NJ, Lee SH
- KMID: 2284204
- Gut Liver.
- 2010 Jun;4(2):292-293.
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- Frameshift Mutation of MARS Gene Encoding an Aminoacyl-tRNA Synthetase in Gastric and Colorectal Carcinomas with Microsatellite Instability
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Park SW, Kim SS, Yoo NJ, Lee SH
- KMID: 1974153
- Gut Liver.
- 2010 Sep;4(3):430-431.
No abstract available. -
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- Loss of Heterozygosity using Microsatellite Marker in plasma of patients with ovarian cancer
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Kim YM, Kim YT, Lee KW
- KMID: 2076675
- Korean J Obstet Gynecol.
- 2002 Sep;45(9):1505-1510.
OBJECTIVE: Recent studies demonstrated that soluble tumor DNA is found in the plasma of cancer patients, and some microsatellite alteration have been identified in ovarian carcinoma. The aim of study... -
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- Hereditary Nonpolyposis Colorectal Cancer
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Oh BY
- KMID: 2367894
- Ewha Med J.
- 2017 Jan;40(1):29-34.
- doi: 10.12771/emj.2017.40.1.29
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common hereditary colorectal cancer syndrome and accounts for about 5% of colorectal cancer. It is inherited as autosomal dominant type and is... -
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- Understanding of molecular pathogenesis and genetic markers in colorectal cancer
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Kim YH
- KMID: 2259110
- Korean J Med.
- 2010 Aug;79(2):113-118.
Colorectal cancers results from the progressive accumulation of genetic and epigenetic alterations that lead to cellular transformation and tumor progression. Genomic instability, including chromosomal translocations and microsatellite instability, plays a... -
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- Microsatellite Instability and the Expression of Tumor-associated Genes in Multiple Cancer
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Kim KS, Choi C, Park CS, Juhng SW
- KMID: 1979414
- Korean J Pathol.
- 1997 Jul;31(7):617-627.
Genetic changes associated with oncogenes or tumor suppressor genes are frequently observed in human cancers. These changes may be more frequent in multiple primary cancers than sporadic cancers. ... -
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- Correlation MSI Status and Other Prognostic Factors in Sporadic Colorectal Cancer
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Lee SN
- KMID: 1964092
- Ewha Med J.
- 2004 Sep;27(2):101-105.
- doi: 10.12771/emj.2004.27.2.101
OBJECTIVES: The purpose of this study was to evaluate MSI status in sporadic colorectal cancer and to correlate it with clinicopathologic variables. METHODS: Total 45 cases of surgically resected colorectal cancers... -
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- Analysis of Microsatellite Instability and Loss of Heterozygosity in Sporadic Keratoacanthoma
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Ha TW, Han KH, Kim DK
- KMID: 2030772
- Korean J Anat.
- 2005 Feb;38(1):55-61.
Tumors from patients with hereditary non-polyposis colorectal cancer (HNPCC)and from a subset of patients with the related Muir-Torre syndrome exhibit a type of a genetic instability, known as microsatellite instability... -
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- Microsatellite instability analysis on epithelial ovarian tumor
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Kim SS, Park IS
- KMID: 2143515
- Korean J Gynecol Oncol.
- 2006 Dec;17(4):302-309.
OBJECTIVE: Some genetic alterations are involved in ovarian carcinogenesis. Since some benign and borderline tumors may represent early steps in ovarian carcinogenesis, analysis of precursor lesions could provide evidence that... -
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- Loss of Heterozygosity and Microsatellite Instability at Multiple Tumor Suppressor Genes in Gastric Carcinomas
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Cho YG, Kim CJ, Park CH, Kim YS, Kim SY, Nam SW, Lee SH, Yoo NJ, Lee JY, Park WS
- KMID: 2372736
- J Korean Gastric Cancer Assoc.
- 2003 Dec;3(4):214-220.
PURPOSE: The aim of this study was to investigate the frequency of loss of heterozygosity and the microsatellite instability at multiple tumor suppressor gene loci in gastric adenocarcinomas. MATENRIALS AND METHODS:... -
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- Clinical Application of Genetics in Management of Colorectal Cancer
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Kim ER, Kim YH
- KMID: 2174377
- Intest Res.
- 2014 Jul;12(3):184-193.
- doi: 10.5217/ir.2014.12.3.184
The extensive study of genetic alterations in colorectal cancer (CRC) has led to molecular diagnostics playing an increasingly important role in CRC diagnosis and treatment. Currently, it is believed that... -
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- Microsatellite Instability and Mismatch Repair Protein (hMLH1, hMSH2) Expression in Intrahepatic Cholangiocarcinoma
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Kang YK, Kim WH
- KMID: 2275436
- Korean J Pathol.
- 2005 Feb;39(1):9-14.
BACKGROUND: To clarify the role of the mismatch repair (MMR) system in the carcinogenesis of intrahepatic cholangiocarcinoma (ICC), we investigated the microsatellite instability (MSI) status and MMR protein expression in... -
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- Microsatellite Instability and hMSH2 Gene Mutations in Sporadic Colorectal Cancers
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Jeon HM, Oh ST, Kim JS, Chang SK, Kim JS
- KMID: 2101319
- J Korean Soc Coloproctol.
- 1998 Mar;14(1):41-49.
Microsatellites are short nucleotide repeat sequences present throughout the human genome. Alterations of microsatellites, comprising extra or missing copies of these se quences, have been termed microsatellite instability(MSI, genetic instability,... -
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- Mechanism of Genomic Instability and Its Clinical Applications
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Lee SH
- KMID: 2334315
- J Korean Soc Coloproctol.
- 2004 Feb;20(1):64-73.
Multiple genetic alterations are common prerequisite for carcinogenesis including colorectal cancers (CRCs). Recently, mutations within microsatellites have been described as a result of defective DNA mismatch repair (MMR) mechanisms, resulting... -
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