Korean J Intern Med.
2004 Mar;19(1):58-61.
Agranulocytosis Induced by Vancomycin in an ESRD Patient on CAPD
- Affiliations
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- 1Division of Nephrology, Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea. josong@kku.ac.kr
Abstract
- Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA) -associated external cuff infection and pneumonia. The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.
MeSH Terms
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Aged
Agranulocytosis/*chemically induced/drug therapy
Anti-Bacterial Agents/*adverse effects/therapeutic use
Catheters, Indwelling/microbiology
Granulocyte Colony-Stimulating Factor/therapeutic use
Human
Kidney Failure, Chronic/complications/therapy
Male
Peritoneal Dialysis, Continuous Ambulatory
Staphylococcal Infections/drug therapy
Vancomycin/*adverse effects/therapeutic use
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