Korean J Intern Med.  1998 Feb;13(1):22-26.

Changes of the carotid artery Doppler flow velocity pattern after sublingual nitroglycerin in patients with hypertension

• Jeong JW
• Park OK
• Park YK
• Tei C
• Tanaka N

Abstract

OBJECTIVE
To evaluate the applicability of carotid Doppler echography for the assessment of changes of peripheral hemodynamics in the hypertensives. SUBJECTS: 28 hypertensives (17 males, 11 females), mean age of 64 yrs and 40 normal controls (24 males, 16 females) mean age of 49 yrs. METHODS: We recorded the right common carotid arterial Doppler flow velocity (BFV) pattern and measured the peak velocities of the percussion wave (P) and late rising tidal wave (T), the ratio of the two (P/T), the time interval between the two peaks corrected by heart rate (P-Tc), systolic flow velocity integral (FVI) and carotid artery diameter (CAD) before and after 0.4 mg dose of subligual nitroglycerin (NTG). RESULTS: 1) In hypertensives, the P wave velocity showed lower and P-Tc interval shorter than those of the normal controls at baseline. 2) After NTG, the P-Tc and P/T increased, but the T and FVI decreased significantly in both groups of subjects. 3) The P/T ratio was less significantly increased after NTG in the hypertensives than in the controls. These results suggest that NTG might have been involved in concomitant reduction and delay of the wave reflection from the peripheral vessels, preferentially in the normal subjects than in hypertensives. CONCLUSIONS: The carotid Doppler echography can be useful for the evaluation of the changes of hemodynamics in the peripheral vessel such as carotid artery in hypertensive subjects.

MeSH Terms

Administration, Sublingual
Blood Flow Velocity/drug effects
Carotid Arteries/ultrasonography
Carotid Arteries/drug effects
Case-Control Studies
Female
Human
Hypertension/ultrasonography
Hypertension/physiopathology*
Hypertension/drug therapy*
Male
Middle Age
Nitroglycerin/administration & dosage*
Ultrasonography, Doppler, Color
Vasodilator Agents/administration & dosage*