Yonsei Med J.  2007 Jun;48(3):535-539. 10.3349/ymj.2007.48.3.535.

Comparison of Sporadic Sclerotic Fibroma and Solitary Fibrous Tumor in the Oral Cavity

• Lee JH
• An JS
• Lee ES
• Kwon SY
• Kim YS

• KMID: 724112
• DOI: http://doi.org/10.3349/ymj.2007.48.3.535

Abstract

Sporadic sclerotic fibroma (SF) and solitary fibrous tumor (SFT) arising in the oral cavity are very rare. In this report, we describe two cases of oral pathology, one involving SF and the other involving SFT. Both cases presented with well- circumscribed, firm nodules with similar gross findings. However, the histologic findings of the SF and SFT showed rather distinct features. The SF was composed of hyalinized sclerotic collagen bundles arranged in a whorled pattern, whereas the SFT was formed by spindles cells arranged in hypo- and hypercellular areas. The immunohistochemical findings were similar in both cases; there was positivity for vimentin, CD34, and CD99, but bcl-2 positivity was only seen in the SFT. Although their histopathologies are similar, SF and SFT should be considered in the differential diagnosis of soft tissue tumors in the oral cavity.

Keyword

Sclerotic fibroma; solitary fibrous tumor; oral cavity; bcl-2

MeSH Terms

Adult
Antigens, CD/analysis
Antigens, CD34/analysis
Cell Adhesion Molecules/analysis
Diagnosis, Differential
Female
Fibroma/*diagnosis/metabolism
Humans
Immunohistochemistry
Mouth/chemistry/*pathology
Mouth Neoplasms/*diagnosis/metabolism
Neoplasms, Fibrous Tissue/*diagnosis/metabolism
Proto-Oncogene Proteins c-bcl-2/analysis
Vimentin/analysis

Figure

• 

  Fig. 1 (A) Low magnification of the microscopic findings for sclerotic fibroma, which is a relatively well demarcated submucosal mass (× 20, H & E stain). (B) Low magnification of the microscopic finding for solitary fibrous tumor, which is a sharply circumscribed submucosal mass (× 20, H & E stain). (C) The thick eosinophilic collagen bundles are separated by prominent clefts (× 200, H & E stain). (D) The hypocellular and hypercellular areas are mixed (× 200, H & E stain). (E) The tumor cells of sclerotic fibroma are negative for bcl-2 (× 400), but positive for CD34 (Inset, × 400). (F) The tumor cells of solitary fibrous tumor are positive for bcl-2 (× 400) and CD34 (Inset, × 400).

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