Yonsei Med J.  2004 Aug;45(4):727-735. 10.3349/ymj.2004.45.4.727.

Kearns-Sayre Syndrome: 3 Case Reports and Review of Clinical Feature

• Park SB
• Ma KT
• Kook KH
• Lee SY

• KMID: 721427
• DOI: http://doi.org/10.3349/ymj.2004.45.4.727

Abstract

Kearns-Sayre syndrome, first described by Kearns and Sayre in 1958, is a rare disorder consisting of ptosis, limited movement of both eyes and atypical retinal pigmentary change (salt-pepper like appearance). Most cases have shown an increase in the concentration of mitochondria and ragged-red fiber under Gomori-trichrome staining on muscle biopsy. Occasionally, it is combined with other neurologic and endocrinologic symptoms such as ataxia, dementia, diabetes, and hyperaldosteronism. We recently experienced three cases of male teenaged patients who expressed the clinical features of Kearns-Sayre syndrome.

Keyword

Atypical retinal pigmentary change; kearns-sayre syndrome; ptosis; ragged-red fiber

MeSH Terms

Adolescent
Adult
Atrophy
Biopsy
Blepharoptosis/*pathology
Electrooculography
Humans
Kearns-Sayer Syndrome/*pathology
Male
Muscle, Skeletal/*pathology
Ophthalmoscopes
Retina/*pathology