Intest Res.
2025 Apr;23(2):117-128. 10.5217/ir.2024.00085.
Role of 5-aminosalicylic acid in ulcerative colitis management in 8 Asian territories: a physician survey
- Limsrivilai J
1 - Lai AYh2,3
- Li STH4
- Abdullah M5
- Ali RAR6
- Aniwan S7
- Bui HH8
- Chou JW9
- Hilmi IN10
- Lim WC11
- Sollano J12
- Teo MMH3
- Wei SC13
- Leung WK14
- Affiliations
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- 1Division of Gastroenterology, Siriraj Hospital, Mahidol University, Bangkok, Thailand
- 2Global Health Program, College of Public Health, National Taiwan University, Taipei, Taiwan
- 3Ferring Pharmaceuticals Ltd., Singapore
- 4Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
- 5Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Human Cancer Research Center - Indonesian Medical Education and Research Institute, Faculty of Medicine/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
- 6School of Medical and Life Sciences, Sunway University, Kuala Lumpur, Malaysia
- 7Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
- 8Department of Gastroenterology, University Medical Center, Ho Chi Minh City, Vietnam
- 9Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan
- 10Division of Gastroenterology and Hepatology, Department of Medicine, University Malaya, Kuala Lumpur, Malaysia
- 11Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore
- 12Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines
- 13Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
- 14Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
- KMID: 2567619
- DOI: http://doi.org/10.5217/ir.2024.00085
Abstract
- Clinical guidelines typically endorse conventional therapies such as 5-aminosalicylic acid (5-ASA) as the mainstay of ulcerative colitis management. However, the degree of adoption and application of guideline recommendations by physicians within Asia remains unclear. This study aims to understand the prescribing patterns of 5-ASA and implementation of current guideline recommendations across Asian clinical practice. A physician survey was conducted among inflammatory bowel disease specialists in 8 Asian territories to understand practices and preferences in ulcerative colitis management, focusing on the use of 5-ASA and concordance with guideline recommendations. Survey findings were validated by country experts in diverse healthcare settings. Subgroup analyses stratified data by income levels and treatment reimbursement status. Ninety-eight valid responses were received from inflammatory bowel disease specialists or gastroenterologists among 8 economic entities. Significant differences were found in clinical practices and treatment preferences for ulcerative colitis management among different income-level and government-subsidy groups. Survey results are summarized in 8 findings that illustrate trends in 5-ASA use and guideline implementation across Asian territories. This study emphasizes socioeconomic factors that impact the adoption of guideline recommendations in real-world practice. Our findings indicate an eclectic approach to guideline implementation across Asia, based on resource availability and feasibility of treatment goals.
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