Clin Exp Pediatr.
2025 May;68(5):362-369. 10.3345/cep.2024.01151.
Serum bactericidal activity against meningococcus in patients with systemic lupus erythematosus
- Affiliations
-
- 1Division of Immunology, Seoul National University Children’s Hospital, Seoul, Korea
- 2Department of Pediatrics, Hallym University Sacred Heart Hospital, Seoul, Korea
- 3Department of Pediatrics, Ewha Womans University College of Medicine, Seoul, Korea
- 4Center for Vaccine Evaluation and Study, Ewha Womans University College of Medicine, Seoul, Korea
- 5Department of Pediatrics, Ewah Womans University Seoul Hospital, Seoul, Korea
- 6Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea
- KMID: 2567612
- DOI: http://doi.org/10.3345/cep.2024.01151
Abstract
- Background
Patients with systemic lupus erythematosus (SLE) are susceptible to infectious diseases owing to various immunosuppressive treatments and disease characteristics. Meningococcal infections progress rapidly with a high incidence of severe complications and mortality; therefore, meningococcal vaccination is needed. However, there is limited evidence regarding the immunity and immunogenicity of patients with SLE. Purpose: This study aimed to analyze the serum bactericidal activity against meningococci in patients with SLE in 2 domestic institutions in Korea.
Methods
Serum samples were collected from patients diagnosed with SLE (age <19 years) at Seoul National University Children's Hospital and Ewha Womans University Mokdong Hospital in 2016–2018. Serum bactericidal activity against the 4 meningococcal serogroups was analyzed using a serum bactericidal assay with rabbit serum. The patients' demographic information, diagnostic history, and disease activity status were obtained from electronic medical records.
Results
The mean age of the 41 included patients was 20.3±5.4 years (range, 10–35 years). All but one patient received steroids. The sera of most of the patients (34 of 41 [82.9%]) lacked bactericidal activity against serogroup A. Some patients showed bactericidal activity against serogroups C, W-135, and Y (63.4%, 56.1%, and 61.0%, respectively). There were no significant differences in the geometric mean indices based on complement consumption state or anti-double-stranded DNA antibody positivity.
Conclusion
Although the sera of some patients exhibited serum bactericidal activity against meningococci, most remained seronegative. It is important that patients with SLE at risk of meningococcal infection receive appropriate vaccinations. Our findings serve as baseline serological data for meningococcal vaccination policies for patients with SLE.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of Transverse Myelitis as a First Manifestation of Systemic Lupus Erythematosus
- Correlation of Serum Nitric Oxide Levels and Disease Activity of Systemic Lupus Erythematosus
- A Case Of Systemic Lupus Erythematosus Associated With Hyperthyroidism And Severe Retinopathy
- A Case of Lupus Enteritis That Developed during the Treatment of Systemic Lupus Erythematosus
- Multiple Dermatofibromas in a woman with Systemic Lupus Erythematosus
