Ann Coloproctol.
2025 Apr;41(2):136-144. 10.3393/ac.2024.00227.0032.
Relationships between MMP-2, MMP-9, and ADAMDEC1 serum and tissue levels in patients with colorectal cancer
- Affiliations
-
- 1Antimicrobial Resistance Research Center, Institute of Immunology, and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
- 2Department of Internal Medicine, Iran University of Medical Sciences, Tehran, Iran
- 3Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
- 4School of Medicine, Iran University of Medical Sciences, Tehran, Iran
- KMID: 2567449
- DOI: http://doi.org/10.3393/ac.2024.00227.0032
Abstract
- Purpose
Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal system globally. Identifying specific gene expression patterns indicative of early-stage CRC could enable early diagnosis and rapid treatment initiation. Matrix metalloproteinases (MMPs) play crucial roles in extracellular matrix degradation and tissue remodeling. Among them, MMP-2 and MMP-9 have been found to be upregulated in various cancers, including CRC, and are associated with tumor invasion, metastasis, and angiogenesis. In contrast, a disintegrin and metalloproteinase like decysin 1 (ADAMDEC1) is a relatively newly discovered gene with demonstrated involvement in immune response and inflammation. This study investigated serum levels of MMP-2 and MMP-9, along with tissue expression of MMP-2, MMP-9, and ADAMDEC1, and explored potential associations with pathological and clinical factors in patients with CRC.
Methods
This study included 100 patients with CRC and 100 control participants. Tissue and blood samples were collected. Serum MMP-2 and MMP-9 levels were analyzed using the enzyme-linked immunosorbent assay. Quantitative real-time polymerase chain reaction was employed to assess the expression levels of MMP-2, MMP-9, and ADAMDEC1 in CRC tissue samples compared to adjacent control tissue.
Results
The expression levels of MMP-2, MMP-9, and ADAMDEC1 were significantly upregulated in CRC relative to adjacent control tissues. Analysis of clinicopathological features revealed statistically significant differences in the expression levels of MMP-2, MMP-9, and ADAMDEC1 between patients with CRC with and without lymphovascular invasion (P<0.001). Based on receiver operating characteristic curve analysis, these genes represent promising candidate diagnostic biomarkers for CRC.
Conclusion
MMP-2, MMP-9, and ADAMDEC1 levels may serve as potential diagnostic biomarkers for CRC.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Clinical significance of the serum levels of matrix metalloproteinases and the tissue inhibitors of metalloproteinases for gastric and colorectal cancer patients
- Expression of Tumor Metastasis Related Genes in Korean Colorectal Cancers and Cell lines
- Immunodetections of the Metalloproteinase (MMP-2 and MMP-9) and Tissue Inhibitor of Metalloproteinases (TIMP-2) in Prostatic Adenocarcinomas
- MMP-2 and MMP-9 Expressions in Breast Carcinomas and Relationship with Major Prognostic Factors
- Clinical Significances of Serum TGF-Beta1 and MMP-2 Levels in the Patients with Cervical Cancer and Cervical Intraepithelial Neoplasia
