Precis Future Med.  2025 Mar;9(1):43-52. 10.23838/pfm.2025.00065.

Statins: a tale of two pathways—cardiovascular savior, renal ineffectual

• Yang J

• KMID: 2567082
• DOI: http://doi.org/10.23838/pfm.2025.00065

Abstract

Statins are effective in improving outcomes in the general population. However, in patients with chronic kidney disease (CKD), clinical outcomes and therapeutic approaches require careful interpretation from multiple perspectives. Managing dyslipidemia in CKD presents unique challenges requiring a comprehensive understanding of alterations in lipid metabolism in renal dysfunction. This review explored the key factors influencing statin efficacy, safety, and guideline recommendations in the CKD population, with a focus on lipid-lowering strategies tailored to renal function.

Keyword

Hydroxymethylglutaryl-CoA reductase inhibitors; Hydroxymethylglutaryl CoA reductases; Hyperlipidemias; Renal dialysis; Renal insufficiency, chronic