Korean J Blood Transfus.
2024 Apr;35(1):27-32. 10.17945/kjbt.2024.35.1.2 7.
Clinical Indications for RHD Genotyping in Koreans
- Affiliations
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- 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 2Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea
- 3Molecular Research Institute, Seegene Medical Foundation, Seoul, Korea
- KMID: 2555556
- DOI: http://doi.org/10.17945/kjbt.2024.35.1.2 7
Abstract
- RHD genotyping is used primarily when serological tests alone are insufficient to accurately determine the RhD blood type, especially in RhD-negative or RhD variant (D variant) cases. The frequency of RhD-negative and D variants varies significantly according to ethnicity, influencing clinical utilization differently in Korea and Europe. RHD genotyping has multiple applications, including non-invasive prenatal testing, assessment of RhIG administration suitability, identification of weak D and Asian-type DEL in patients, confirmation of D variants in donors, and determination of RhD blood type in patients with weak or discrepant D antigen results. Specifically, detecting Asian-type DEL in serologically RhD-negative individuals is crucial for Koreans, while accurately identifying Weak D types 1, 2, 3, 4.0, and 4.1 in serologically RhD weak-positive samples is vital for Europeans.
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